Results 21 to 30 of about 31,021,495 (194)

c-di-AMP–DasR signaling axis mediates mycobacterial acid resistance

mBio
Pathogenic mycobacteria encounter acidic environments during host invasion, necessitating sophisticated acid resistance mechanisms. Here, we identify the GntR family regulator DasR as a conserved cyclic di-AMP (c-di-AMP) receptor in Mycobacterium ...
Yu Fu, Xue-Qin Xie, Zhan-Hui Xu, Yi-Fan Liang, Shi-Qi Yang, Bang-Ce Ye, Di You   +6 more
doaj   +1 more source

c-di-AMP is a central regulator of osmotic homeostasis in GBS.

, 2018
Coordination of osmotic transporters by c-di-AMP occurs at the post-translational and transcriptional levels. The KtrA and TrkH potassium transporter subunits and the OpuCA osmolyte transporter subunit are conserved c-di-AMP binding proteins.
Maria-Vittoria Mazzuoli (5105312), Myriam Gominet (58093), Arnaud Firon (132290), Laura Devaux (5105309), Philippe Lanotte (202685), Dona Sleiman (418698), Pierre-Alexandre Kaminski (5105315), Patrick Trieu-Cuot (137125)   +7 more
core   +1 more source

The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis

eLife
The obligate intracellular bacterium Chlamydia alternates between two functional forms during its developmental cycle: elementary body (EB) and reticulate body (RB).
Junghoon Lee, Scot P Ouellette
doaj   +1 more source

Regulation of gingival epithelial cytokine response by bacterial cyclic dinucleotides

Journal of Oral Microbiology, 2019
Background: Cyclic dinucleotides (cyclic di-guanosine monophosphate (c-di-GMP) and cyclic di-adenosine monophosphate (c-di-AMP)) and lipopolysaccharides (LPS) are pathogen-associated molecular patterns (PAMPs).
Samira Elmanfi, Jie Zhou, Herman O. Sintim, Eija Könönen, Mervi Gürsoy, Ulvi Kahraman Gürsoy   +5 more
doaj   +1 more source

c-di-AMP binds three transporters subunits and a transcriptional factor.

, 2018
(A) Interaction of radiolabelled c-di-AMP with targeted protein by DRaCALA. Full-length proteins were expressed in E. coli, except for EriC where only the RCK_C can be expressed. Whole E.
Maria-Vittoria Mazzuoli (5105312), Myriam Gominet (58093), Arnaud Firon (132290), Laura Devaux (5105309), Philippe Lanotte (202685), Dona Sleiman (418698), Pierre-Alexandre Kaminski (5105315), Patrick Trieu-Cuot (137125)   +7 more
core   +1 more source

Identification of the Components Involved in Cyclic Di-AMP Signaling in Mycoplasma pneumoniae

Frontiers in Microbiology, 2017
Bacteria often use cyclic dinucleotides as second messengers for signal transduction. While the classical molecule c-di-GMP is involved in lifestyle selection, the functions of the more recently discovered signaling nucleotide cyclic di-AMP are less ...
Cedric Blötz, Katrin Treffon, Volkhard Kaever, Frank Schwede, Elke Hammer, Jörg Stülke   +5 more
doaj   +1 more source

Identification of novel genetic factors that regulate c-di-AMP production in Staphylococcus aureus using a riboswitch-based biosensor

mSphere
Nucleotide secondary messengers regulate various processes in bacteria allowing them to rapidly respond to changes in environmental conditions. c-di-AMP is an essential second messenger required for the growth of the human pathogen Staphylococcus aureus,
Igor Kviatkovski, Qiyun Zhong, Sanika Vaidya, Angelika Gründling   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Potenziale risparmio idrico derivante da interventi di sietmazione idraulico-agraria di appezamenti irrigati con tecnica per scorrimento superficiale. [PDF]

L'irrigazione per scorrimento superficiale è uno dei metodi più antichi e diffusi al mondo per irrigare le colture a filari. Circa il 90% dell'area irrigata su scala mondiale, utilizza tecniche di irrigazione per scorrimento superficiale (Singh & ...
Fabiola Gangi, Giuseppe Argirò, Carmelina Costanzo, Pierfranco Costabile, Daniele Masseroni, Claudio Gandolfi &   +5 more
core   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source