Results 31 to 40 of about 31,021,495 (194)

Cyclic di-AMP signaling and regulation in Staphylococcus aureus

mSphere
Cyclic di-AMP (c-di-AMP) is an essential bacterial second messenger that coordinates multiple cellular processes and is closely linked to central physiology in many bacteria. In Staphylococcus aureus, both depletion and excessive accumulation of c-di-AMP
Seonmin Lee, Ji-Hoon Kim, Taegwan Yun, Wonsik Lee   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Insights into the activation mechanism of PopA, a cyclic di-GMP effector protein involved in cell cycle and development of "Caulobacter Crescentus" [PDF]

, 2012
In Caulobacter crescentus, a complex network integrating cyclic di-GMP and Phosphorylation-dependent signals controls the proteolysis of key regulatory proteins to drive cell cycle and polar morphogenesis.
Schalch-Moser, Annina Larissa
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

C-di-AMP levels in non-growing energised cells respond rapidly to environmental osmolarity changes.

, 2018
(A) Schematic diagram showing the steps in the non-growing cell suspension assay. Cells are suspended in a low osmolarity buffer causing water influx. Glucose is added to energise the cells at time 0 to provide ATP for c-di-AMP synthesis.
Nguyen Thi Hanh Nhiep (5593412), Christopher B. Howard (4529158), Anh Le Diep Huynh (5593418), Huong Thi Pham (5593409), Thu Ngoc Minh Vu (5593415), Alolika Chakrabortti (3490670), Esteban Marcellin (1677523), Nidhi Bansal (199948), TuAnh Ngoc Huynh (5047550), Zhao-Xun Liang (208114), Joshua J. Woodward (2273068), Yan Zhu (112437), Raquel Lo (5593421), Mark S. Turner (721735)   +13 more
core   +1 more source

Cyclic nucleotides in archaea: Cyclic di‐AMP in the archaeon Haloferax volcanii and its putative role

MicrobiologyOpen, 2019
The role of cyclic nucleotides as second messengers for intracellular signal transduction has been well described in bacteria. One recently discovered bacterial second messenger is cyclic di‐adenylate monophosphate (c‐di‐AMP), which has been demonstrated
Frank Braun, Laura Thomalla, Chris van derDoes, Tessa E. F. Quax, Thorsten Allers, Volkhard Kaever, Sonja‐Verena Albers   +6 more
doaj   +1 more source

C-di-AMP levels modulate Staphylococcus aureus cell wall thickness, response to oxidative stress, and antibiotic resistance and tolerance

Microbiology Spectrum, 2023
Beta-lactam antibiotics are widely used to treat infections caused by the important human pathogen Staphylococcus aureus. Resistance to beta-lactams, as found in methicillin-resistant S. aureus, renders effective treatment difficult. The second messenger
Vanina Dengler Haunreiter, Andrea Tarnutzer, Julian Bär, Manuela von Matt, Sanne Hertegonne, Federica Andreoni, Clément Vulin, Lisa Künzi, Carmen Menzi, Patrick Kiefer, Philipp Christen, Julia A. Vorholt, Annelies S. Zinkernagel   +12 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Post-Transcriptional Inflammatory Response to Intracellular Bacterial c-di-AMP

Frontiers in Immunology, 2020
Cyclic-di-AMP (c-di-AMP) is a bacterial second messenger that is produced by intracellular bacterial pathogens in mammalian host macrophages. Previous reports have shown that c-di-AMP is recognized by intracellular pattern recognition receptors of the ...
Linah Mahmoud, Alaa S. Abdulkarim, Shaima Kutbi, Walid Moghrabi, Sulaiman Altwijri, Khalid S. A. Khabar, Edward G. Hitti   +6 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source