Results 21 to 30 of about 43,345 (260)

Direct functionalization of C−H bonds by electrophilic anions [PDF]

Proceedings of the National Academy of Sciences, 2020
Significance Functionalization of unreactive molecules is a significant chemical challenge relevant to the conversion of abundant feedstocks such as alkanes into high-value chemicals. Herein, we demonstrate a new mechanism of alkane functionalization by the substitution of a proton by an anion in an alkyl chain.
Jonas Warneke, Martin Mayer, Markus Rohdenburg, Xin Ma, Judy K. Y. Liu, Max Grellmann, Sreekanta Debnath, Vladimir A. Azov, Edoardo Apra, Robert P. Young, Carsten Jenne, Grant E. Johnson, Hilkka I. Kenttämaa, Knut R. Asmis, Julia Laskin   +14 more
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Distal Functionalization via Transition Metal Catalysis

Chemistry Proceedings, 2022
The ubiquitous presence of sp3 C−H bonds in natural feedstock makes them inexpensive, easily accessible, and attractive synthons for the preparation of common and/or complex molecular frameworks in biologically active natural products, pharmaceutics ...
Haibo Ge
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Anaerobic functionalization of unactivated C–H bonds [PDF]

Current Opinion in Chemical Biology, 2009
The functionalization of alkanes was once thought to lie strictly within the domain of enzymes that activate dioxygen in order to generate an oxidant with suitable potency to cleave inert C-H bonds. The emergence of the radical SAM superfamily of enzymes-those which use S-adenosyl-l-methionine as a precursor to a 5'-deoxyadenosyl 5'-radical-has kindled
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Cp∗Rh/Ag catalyzed C–H activation/cyclization sequences of NH-sulfoximines to fused aza-polyheterocycles under gentle conditions

Green Synthesis and Catalysis, 2023
Disclosed herein is a novel Rh/Ag co-catalyzed SNH directed C–H activation and C–H/N–H bond functionalization protocol of free NH-sulfoximines with hypervalent iodonium ylides.
Jiapian Huang, Fei Liu, Feihua Du, Linghui Zeng, Zhiyuan Chen   +4 more
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Synthesis of Phthalides and α,β-butenolides by Transition Metal-Catalyzed Activation of C—H Bonds

Molecules, 2019
Phthalides and α,β-butenolides are two related classes of oxygenated heterocycles with a wide range of biological activities. An innovative strategy to prepare these compounds is based on C—H bond functionalization reactions, in which two
Andrea Renzetti, Kozo Fukumoto
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Robust molecular trends in Pd-catalyzed C(sp2/sp3)-H activation reactions – A review

Results in Chemistry, 2021
Direct functionalization of inert C–H bonds into various C-X (X = C, N, O, S) functionalities is one of the frontier research topics and regularly gaining popularities among the communities of scientists by providing opportunities for direct synthesis of
Pravati Panda, Kaushik Pal, Subhendu Chakroborty   +2 more
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Site-selective functionalization of remote aliphatic C–H bonds via C–H metallation

Chemical Science, 2021
Recent advances in site-selective functionalization of remote aliphatic C–H bonds in organometallic pathways are summarized.
Qi Zhang, Bing-Feng Shi
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Recent Advances in the Nickel-Catalyzed Alkylation of C-H Bonds

Molecules
Functionalization of C-H bonds has emerged as a powerful strategy for converting inert, nonfunctional C-H bonds into their reactive counterparts.
Franc Požgan, Uroš Grošelj, Jurij Svete, Bogdan Štefane, Hamad H. Al Mamari   +4 more
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Selective Dealkenylative Functionalization of Styrenes via C-C Bond Cleavage

Research, 2020
As a readily available feedstock, styrene with about 25 million tons of global annual production serves as an important building block and organic synthon for the synthesis of fine chemicals, polystyrene plastics, and elastomers.
Jianzhong Liu, Jun Pan, Xiao Luo, Xu Qiu, Cheng Zhang, Ning Jiao   +5 more
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Recent Developments in Transition-Metal Catalyzed Direct C–H Alkenylation, Alkylation, and Alkynylation of Azoles

Molecules, 2020
The transition metal-catalyzed C–H bond functionalization of azoles has emerged as one of the most important strategies to decorate these biologically important scaffolds. Despite significant progress in the C–H functionalization of various heteroarenes,
Su Chen, Prabhat Ranjan, Leonid G. Voskressensky, Erik V. Van der Eycken, Upendra K. Sharma   +4 more
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