Results 21 to 30 of about 105,861 (299)
Iridium-Catalyzed Silylation of Five-Membered Heteroarenes: High Sterically Derived Selectivity from a Pyridyl-Imidazoline Ligand. [PDF]
, 2020 The steric effects of substituents on five-membered rings are less pronounced than those on six-membered rings because of the difference in bond angles. Thus, the regioselectivities of reactions of five-membered heteroarenes that occur with selectivities
Hartwig, John F +3 more
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Direct functionalization of C−H bonds by electrophilic anions [PDF]
Proceedings of the National Academy of Sciences, 2020 Significance Functionalization of unreactive molecules is a significant chemical challenge relevant to the conversion of abundant feedstocks such as alkanes into high-value chemicals. Herein, we demonstrate a new mechanism of alkane functionalization by the substitution of a proton by an anion in an alkyl chain.
Jonas Warneke +14 more
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Nature Communications, 2022 Methods to functionalize inert C–H bonds are a critical focus of synthetic organic chemistry. In this work the authors use computations and experiments to uncover the mechanisms of palladium-catalysed C–H lactonizations in aromatic carboxylic acids, and ...
Li-Ping Xu +4 more
doaj +1 more source
Iridium-Catalyzed, β-Selective C(sp3)-H Silylation of Aliphatic Amines To Form Silapyrrolidines and 1,2-Amino Alcohols. [PDF]
, 2018 The functionalization of unactivated C(sp3)-H bonds of aliphatic amines catalyzed by transition-metal complexes is important because amine-based functionality is present in a majority of biologically active molecules and commercial pharmaceuticals ...
Hartwig, John F, Lee, Taegyo, Su, Bo
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Distal Functionalization via Transition Metal Catalysis
Chemistry Proceedings, 2022 The ubiquitous presence of sp3 C−H bonds in natural feedstock makes them inexpensive, easily accessible, and attractive synthons for the preparation of common and/or complex molecular frameworks in biologically active natural products, pharmaceutics ...
Haibo Ge
doaj +1 more source
Site-Selective C−H Arylation of Primary Aliphatic Amines Enabled by a Catalytic Transient Directing Group [PDF]
, 2016 Transition-metal-catalysed direct C–H bond functionalization of aliphatic amines is of great importance in organic and medicinal chemistry research. Several methods have been developed for the direct sp3 C–H functionalization of secondary and tertiary ...
Ge, Haibo, Liu, Yongbing
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Anaerobic functionalization of unactivated C–H bonds [PDF]
Current Opinion in Chemical Biology, 2009 The functionalization of alkanes was once thought to lie strictly within the domain of enzymes that activate dioxygen in order to generate an oxidant with suitable potency to cleave inert C-H bonds. The emergence of the radical SAM superfamily of enzymes-those which use S-adenosyl-l-methionine as a precursor to a 5'-deoxyadenosyl 5'-radical-has kindled
openaire +2 more sources
Synthesis of Phthalides and α,β-butenolides by Transition Metal-Catalyzed Activation of C—H Bonds
Molecules, 2019 Phthalides and α,β-butenolides are two related classes of oxygenated heterocycles with a wide range of biological activities. An innovative strategy to prepare these compounds is based on C—H bond functionalization reactions, in which two
Andrea Renzetti, Kozo Fukumoto
doaj +1 more source
Green Synthesis and Catalysis, 2023 Disclosed herein is a novel Rh/Ag co-catalyzed SNH directed C–H activation and C–H/N–H bond functionalization protocol of free NH-sulfoximines with hypervalent iodonium ylides.
Jiapian Huang +4 more
doaj +1 more source
Manganese(I)-Catalyzed C−H Activation : The Key Role of a 7-Membered Manganacycle in H-Transfer and Reductive Elimination [PDF]
, 2016 Manganese-catalyzed C−H bond activation chemistry is emerging as a powerful and complementary method for molecular functionalization. A highly reactive seven-membered MnIintermediate is detected and characterized that is effective for H-transfer or ...
Ackermann +32 more
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