Results 1 to 10 of about 433,925 (166)
Impact of c-JUN deficiency on thalamus development in mice and human neural models [PDF]
Cell & BioscienceBackground c-Jun is a key regulator of gene expression. Through the formation of homo- or heterodimers, c-JUN binds to DNA and regulates gene transcription.
Jiantao Shi +8 more
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Frontiers in Oncology, 2021 The oncogene c-Jun is activated by Jun N-terminal kinase (JNK). Exosomes are nanometer-sized membrane vesicles released from a variety of cell types, and are essential for cell-to-cell communication.
Chen Shao +12 more
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Stimulation of c-Jun/AP-1-Activity by the Cell Cycle Inhibitor p57Kip2
Frontiers in Cell and Developmental Biology, 2021 p57 is a member of the Cip/Kip family of cell cycle inhibitors which restrict the eukaryotic cell cycle by binding to and inhibiting cyclin/CDK complexes.
Michael Keith Kullmann +3 more
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Anthrax lethal toxin rapidly reduces c-Jun levels by inhibiting c-Jun gene transcription and promoting c-Jun protein degradation [PDF]
Journal of Biological Chemistry, 2017 Anthrax is a life-threatening disease caused by infection with Bacillus anthracis, which expresses lethal factor and the receptor-binding protective antigen. These two proteins combine to form anthrax lethal toxin (LT), whose proximal targets are mitogen-activated kinase kinases (MKKs).
Weiming, Ouyang +3 more
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BMC Cancer, 2022 Purpose To investigate the expression and prognostic value of c-Jun in hypopharyngeal squamous cell carcinoma (HPSCC). Methods A retrospective study was performed on a cohort of 99 HPSCC patients. The expression of c-Jun and phosphorylated-c-Jun (p-c-Jun)
Qiang Huang +4 more
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c-JUN is a barrier in hESC to cardiomyocyte transition
Life Science Alliance, 2023 The study reveals that knocking out c-JUN improves cardiomyocyte generation in humans by increasing chromatin accessibility and H3K4me3 modification on key genes regulating heart development.
Hui Zhong +11 more
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A feed-forward regulation of endothelin receptors by c-Jun in human non-pigmented ciliary epithelial cells and retinal ganglion cells. [PDF]
PLoS ONE, 2017 c-Jun, c-Jun N-terminal kinase(JNK) and endothelin B (ETB) receptor have been shown to contribute to the pathogenesis of glaucoma. Previously, we reported that an increase of c-Jun and CCAAT/enhancer binding protein β (C/EBPβ) immunohistostaining is ...
Junming Wang +4 more
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Radiation-induced c-Jun activation depends on MEK1-ERK1/2 signaling pathway in microglial cells. [PDF]
PLoS ONE, 2012 Radiation-induced normal brain injury is associated with acute and/or chronic inflammatory responses, and has been a major concern in radiotherapy. Recent studies suggest that microglial activation is a potential contributor to chronic inflammatory ...
Zhiyong Deng +3 more
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Wnt2bb Induces Cardiomyocyte Proliferation in Zebrafish Hearts via the jnk1/c-jun/creb1 Pathway
Frontiers in Cell and Developmental Biology, 2020 Previous studies have demonstrated that inhibition of canonical Wnt signaling promotes zebrafish heart regeneration and that treatment of injured heart tissue with the Wnt activator 6-bromo-indirubin-3-oxime (BIO) can impede cardiomyocyte proliferation ...
Xiangwen Peng +10 more
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Analysis of the Interaction between c-Jun and c-Jun N-terminal Kinase in Vivo [PDF]
Journal of Biological Chemistry, 1998 Regulation of c-Jun transcriptional activity is believed to depend on a physical interaction with c-Jun N-terminal kinase (JNK) that facilitates signal-regulated phosphorylation of multiple regulatory phosphoacceptor sites within the activation domain. Here we have investigated the structural requirements and consequences of regulatory phosphorylation ...
G H, May +4 more
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