Results 31 to 40 of about 521,522 (308)
RANKing c-Jun in osteoclast development [PDF]
Journal of Clinical Investigation, 2004 Pathological bone loss always reflects enhanced net osteoclastic activity. Recognition and binding of the receptor activator of NF-κB (RANK) by RANK ligand (RANKL) is the key osteoclastogenic event, and the signaling cascades induced by this reaction therefore contain potential anti-osteoporosis therapeutic targets.
openaire +3 more sources
Rb binds c-Jun and activates transcription [PDF]
The EMBO Journal, 1998 The retinoblastoma protein (Rb) acts as a critical cell-cycle regulator and loss of Rb function is associated with a variety of human cancer types. Here we report that Rb binds to members of the AP-1 family of transcription factors, including c-Jun, and stimulates c-Jun transcriptional activity from an AP-1 consensus sequence.
M A, Nead +4 more
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The small GTP-binding protein RhoA regulates c-Jun by a ROCK-JNK signaling axis [PDF]
, 2004 RhoA regulates the actin cytoskeleton and the expres- sion of genes associated with cell proliferation. This includes c-fos and c-jun, which are members of the AP1 family of transcription factors that play a key role in normal and aberrant cell growth ...
Bernard, Ora +5 more
core +2 more sources
Barriers to transmission of transcriptional noise in a c‐fos c‐jun pathway
Molecular Systems Biology, 2013 We explored how transcriptional noise propagates in gene‐regulatory pathways by studying the induction of two downstream genes by transcription factors c‐fos and c‐jun.
Khyati Shah, Sanjay Tyagi
doaj +1 more source
Expression of MKK7 and Phospho-c-Jun in Glioma and Their Correlation
Zhongliu Fangzhi Yanjiu, 2019 Objective To investigate the expression of phospho-c-Jun and MKK7 in gliomas and their correlation. Methods We collected and analyzed retrospectively 92 cases of gliomas, including 15 cases of diffuse astrocytoma, 5 cases of oligodendroglioma, 11 cases ...
ZHI Cheng +10 more
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Frontiers in Endocrinology, 2021 In previous studies we have demonstrated that the expression of the Major Histocompatibility Complex (MHC) class I gene in thyrocytes is controlled by several hormones, growth factors, and drugs.
Cesidio Giuliani +11 more
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c-Jun knockdown sensitizes osteosarcoma to doxorubicin [PDF]
Molecular Cancer Therapeutics, 2008 Abstract The oncogene c-Jun has been found to be up-regulated in a variety of cancers, including osteosarcoma. Doxorubicin is a frontline chemotherapeutic against osteosarcoma, but is limited by toxicity. DNAzymes are oligonucleotides capable of specific catalysis of target mRNA. A biocompatible c-Jun DNAzyme nanoparticle formulated from
Dass, Crispin R +2 more
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Nucleolar AATF regulates c-Jun–mediated apoptosis
Molecular Biology of the Cell, 2012 The AP-1 transcription factor c-Jun has been shown to be essential for stress-induced apoptosis in several models. However, the molecular mechanisms underlying the proapoptotic activity of c-Jun are poorly understood. We identify the apoptosis-antagonizing transcription factor (AATF) as a novel nucleolar stress sensor, which is required as a cofactor ...
Ferraris, SE +5 more
openaire +4 more sources
c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK) [PDF]
, 2004 The VRK1 kinase is a novel Ser-Thr kinase in the human kinome that diverged from the casein kinase 1 branch. These kinases phosphorylate transcription factors related to stress responses, such as p53.
Liu, Tingting +5 more
core +1 more source
Functional interaction between macrophages and hepatocytes dictate the outcome of liver fibrosis
Life Science Alliance, 2021 Xie et al demonstrate opposite outcomes on liver fibrosis due to deletion of c-Jun in hepatocytes alone or along with Kupffer cells, highlighting the functional interaction between these cell types in regulating the fibrotic process, dictated by c-Jun ...
Min Xie +5 more
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