Results 41 to 50 of about 521,522 (308)

COOH-Terminal Src Kinase–Mediated c-Jun Phosphorylation Promotes c-Jun Degradation and Inhibits Cell Transformation [PDF]

Cancer Research, 2006
Abstract The oncoprotein c-Jun is a component of the activator protein-1 transcription factor complex, which is involved in cellular proliferation, transformation, and death. The stabilization of c-Jun is critically important for its function.
Feng, Zhu, Bu Young, Choi, Wei-Ya, Ma, Zhongliang, Zhao, Yiguo, Zhang, Yong Yeon, Cho, Hong Seok, Choi, Akira, Imamoto, Ann M, Bode, Zigang, Dong   +9 more
openaire   +2 more sources

Aberrant Polycystin-1 Expression Results in Modification of Activator Protein-1 Activity, whereas Wnt Signaling Remains Unaffected [PDF]

, 2004
Polycystin-1, the polycystic kidney disease 1 gene product, has been implicated in several signaling complexes that are known to regulate essential cellular functions. We investigated the role of polycystin-1 in Wnt signaling and activator protein-1 (
Arnould, Bhunia, Duyndam, Giles, Grotewold, Huan, Kim, Kimberling, Kugoh, Loghman-Adham, Löhning, Morin, Moser, Muto, Newby, Ouwens, Parnell, Peters, Pritchard, Rivat, Rodova, Saadi-Kheddouci, Scheffers, Shaulian, Smits, Sorenson, Spaargaren, Streets, Sutters, Trudel, Upadhya, van Adelsberg, van Dam, van Dam, van Dam, van Dam, van de Wetering, van de Wetering   +37 more
core   +3 more sources

JUNB and JUND in Urological Cancers: A Literature Review

Current Issues in Molecular Biology
JUNB and JUND are two transcriptional factors (TFs) of increased interest in cancer, regulating the expression of genes associated with survival, proliferation, differentiation, migration, invasion, angiogenesis, adhesion, apoptosis, and cell cycle ...
Georgios Kalampounias, Theodosia Androutsopoulou, Panagiotis Katsoris   +2 more
doaj   +1 more source

Dominant Negative c-Jun Inhibits Platelet-Derived Growth Factor- Directed Migration by Vascular Smooth Muscle Cells

Journal of Pharmacological Sciences, 2003
The mitogen≫activated protein (MAP) kinase pathways has been shown to be necessary for mitogen-stimulated proliferation, but its role in cell migration has not been fully understood.
Takeshi Ioroi, Motohiro Yamamori, Keiko Yagi, Midori Hirai, Yumei Zhan, Shokei Kim, Hiroshi Iwao   +6 more
doaj   +1 more source

c-Jun, Foxo3a, and c-Myc Transcription Factors are Key Regulators of ATP-Mediated Angiogenic Responses in Pulmonary Artery Vasa Vasorum Endothelial Cells ^†

Cells, 2020
Angiogenic vasa vasorum (VV) expansion plays an essential role in the pathogenesis of hypoxia-induced pulmonary hypertension (PH), a cardiovascular disease.
Derek Strassheim, Vijaya Karoor, Hala Nijmeh, Philip Weston, Martin Lapel, Jerome Schaack, Timothy Sullivan, Edward C. Dempsey, Kurt R. Stenmark, Evgenia Gerasimovskaya   +9 more
doaj   +1 more source

Adenovirus E1B 19,000-Molecular-Weight Protein Activates c-Jun N-Terminal Kinase and c-Jun-Mediated Transcription [PDF]

Molecular and Cellular Biology, 1998
Adenovirus E1B proteins (19,000-molecular-weight [19K] and 55K proteins) inhibit apoptosis and cooperate with adenovirus E1A to induce full oncogenic transformation of primary cells. The E1B 19K protein has previously been shown to be capable of activating transcription; however, the underlying mechanisms are unclear.
R H, See, Y, Shi
openaire   +2 more sources

TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis. [PDF]

, 2014
In addition to regulating the activation of nuclear factor (NF)-κB and c-Jun N-terminal kinase (JNK), TGF-β activated kinase 1 (TAK1) also upregulates the activation of AMP-activated protein kinase (AMPK) and autophagy.
Seki, Ekihiro
core   +2 more sources

C-jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis

Neuroscience, 2003
Understanding the regulation of the apoptotic program in neurons by intracellular pathways is currently a subject of great interest. Recent results suggest that c-Jun N-terminal kinases (JNK), mitogen-activated protein kinases and the transcription factor c-Jun are important regulators of this cell death program in post-mitotic neurons following ...
Willaime-Morawek, S., Brami-Cherrier, K., Mariani, J., Caboche, J., Brugg, B.   +4 more
openaire   +5 more sources

Arginine methylation of the c‐Jun coactivator RACO‐1 is required for c‐Jun/AP‐1 activation [PDF]

The EMBO Journal, 2013
c-Jun, the major component of the AP-1 transcription factor complex, has important functions in cellular proliferation and oncogenic transformation. The RING domain-containing protein RACO-1 functions as a c-Jun coactivator that molecularly links growth factor signalling to AP-1 transactivation.
Clare C, Davies, Atanu, Chakraborty, Markus E, Diefenbacher, Mark, Skehel, Axel, Behrens   +4 more
openaire   +2 more sources

Differential induction of TLR2/c-Jun and NF-κB signaling pathway in human keratinocytes infected by Trichophyton rubrum and Microsporum gypseum

Pifu-xingbing zhenliaoxue zazhi, 2021
Objective: To explore the activation of TLR2/c-Jun and NF-κB signaling pathway in human keratinocytes infected by different ecological classifications of dermatophytes.
Zhen SU, Weiwei DENG, Shuting ZHAN, Panpan LIANG, Meirong LI, Songchao YIN, Jian CHEN   +6 more
doaj   +1 more source