Results 251 to 260 of about 521,522 (308)

Impact of C-FOS/C-JUN Transcriptional Factors Co-Expression in Non-small Cell Lung Carcinoma. [PDF]

Cancer Diagn Progn
Manios K, Chrysovergis A, Papanikolaou V, Tsiambas E, Adamopoulou M, Stamatelopoulos A, Vachlas Κ, Papouliakos S, Pantos P, Agrogiannis G, Lazaris AC, Kyrodimos E, Tomos P, Kavantzas N.   +13 more
europepmc   +1 more source

SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury

Advanced Science, EarlyView.
After liver transplantation, ischemia‐reperfusion injury is more severe in pericentral regions. Multiomic analyses of human grafts and mouse models identify FOXO1 activation in pericentral hepatocytes as an upstream driver of SAA secretion. SAA recruits and activates FPR2+ macrophages, amplifying local inflammation. Amilo‐5MER inhibits SAA bioactivity,
Feng Zhang, Rong Li, Tingting Wang, Jianhao Zhang, Zhengqi Wu, Qiang You, Xuying Liu, Cuicui Xiao, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Jia Yao, Jun Zheng, Yingcai Zhang, Hua Li, Shuhong Yi, Yang Yang, Qi Zhang, Xiaofeng Yuan, Yasong Liu   +19 more
wiley   +1 more source

PKC-ι Regulates an Oncogenic Positive Feedback Loop Between the MAPK/JNK Signaling Pathway, c-Jun/AP-1 and TNF-α in Breast Cancer. [PDF]

Int J Mol Sci
Nowshin Oishee N, Marzan M, Olatunji AO, Khalid KM, Hasib Shourav A, Noor RE, Kharitonova A, Astalos AJ, Leahy JW, Acevedo-Duncan M.   +9 more
europepmc   +1 more source

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

C-Jun Transcription Factor Oncogenic Activation in Oral Carcinoma. [PDF]

Maedica (Bucur)
Mastronikolis N, Chrysovergis A, Papanikolaou V, Derka S, Asimakopoulos AD, Mastronikoli S, Tsiambas E, Manaios L, Papouliakos S, Ragos V, Fotiades P, Pantos P, Stathopoulos P, Kyrodimos E.   +13 more
europepmc   +1 more source

Enhancing radiosensitivity of osteosarcoma by ITGB3 knockdown: a mechanism linked to enhanced osteogenic differentiation status through JNK/c-JUN/RUNX2 pathway activation. [PDF]

J Exp Clin Cancer Res
Lian Q, Liu H, Li J, Luo C, Liu C, Zhao H, Dai P, Wang B, Zhou H, Jiang X, Wang Z, Qiao S.   +11 more
europepmc   +1 more source

Chemogenetic neuronal silencing decouples c-Jun activation from cell death in the temporal cortex. [PDF]

Eur J Neurosci
Wood CA, Somasundaram P, Dundee JM, Rudy MA, Watkins TA, Jankowsky JL.   +5 more
europepmc   +1 more source

Sirtuin 2 exacerbates renal tubule injury and inflammation in diabetic mice via deacetylation of c-Jun/c-Fos. [PDF]

Cell Mol Life Sci
Chen L, Li D, Zhan Z, Quan J, Peng J, Huang Z, Yi B.   +6 more
europepmc   +1 more source

SIAH2 suppresses c-JUN pathway by promoting the polyubiquitination and degradation of HBx in hepatocellular carcinoma. [PDF]

J Cell Mol Med
Hu Q, Liu Z, Liu Y, Qiu J, Zhang X, Sun J, Zhang B, Shi H.   +7 more
europepmc   +1 more source