Results 271 to 280 of about 521,522 (308)
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Neurosurgery, 2002
Abstract OBJECTIVE Vascular remodeling via apoptotic mechanisms is an important factor in vascular diseases. c-Jun amino-terminal kinase (JNK) is a member of the mitogen-activated protein kinase family and initiates apoptosis mainly via phosphorylation of the c-Jun transcription factor.
Yasushi, Takagi +4 more
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Abstract OBJECTIVE Vascular remodeling via apoptotic mechanisms is an important factor in vascular diseases. c-Jun amino-terminal kinase (JNK) is a member of the mitogen-activated protein kinase family and initiates apoptosis mainly via phosphorylation of the c-Jun transcription factor.
Yasushi, Takagi +4 more
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ATF3 enhances c-Jun-mediated neurite sprouting
Molecular Brain Research, 2003The AP-1 transcription factor c-Jun is induced in axotomized neurons of the peripheral and central nervous systems, and in both cases upregulation of c-Jun expression has been correlated with axonal regeneration. More recently there has been interest in the c-Jun-related bZIP transcription factor, ATF3, and its function in neurons. ATF3 is also induced
Andree G, Pearson +5 more
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Heroin activates Bim via c-Jun N-terminal kinase/c-Jun pathway to mediate neuronal apoptosis
Neuroscience, 2013Heroin is reported to cause spongiform leukoencephalopathy (SLE) in heroin addicts and the exact mechanism has not yet been identified. In the present study, we found that heroin could induce apoptosis of primary cultured cerebellar granule cells (CGCs) and Bim was upregulated both transcriptionally and post transcriptionally during CGCs apoptosis ...
M, Tan +10 more
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Toxicology Methods, 2001
We compared the immunoreactivity of two widely used c-Jun polyclonal antibodies, SC-45 and Ab-1, in normal mouse hepatocytes and in hepatic tumors by means of immunohistochemistry and Western blotting. The epitope of SC-45 contains Thr 91 and Thr 93, both of which are phosphorylated by c-Jun N-terminal kinase. The epitope of Ab-1 contains Ser 252 which
J. Kato-Weinstein +3 more
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We compared the immunoreactivity of two widely used c-Jun polyclonal antibodies, SC-45 and Ab-1, in normal mouse hepatocytes and in hepatic tumors by means of immunohistochemistry and Western blotting. The epitope of SC-45 contains Thr 91 and Thr 93, both of which are phosphorylated by c-Jun N-terminal kinase. The epitope of Ab-1 contains Ser 252 which
J. Kato-Weinstein +3 more
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Bulletin du cancer, 1994
Jun and Fos are major components of the transcriptional complex AP-1 (Activator Protein-1), a collection of dimeric transcriptional activators composed of members of the Jun and Fos family of bZIP proteins, that bind to a common site known as TRE (TPA Responsive Element) or the AP-1 site.
M, Castellazzi, A, Sergeant
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Jun and Fos are major components of the transcriptional complex AP-1 (Activator Protein-1), a collection of dimeric transcriptional activators composed of members of the Jun and Fos family of bZIP proteins, that bind to a common site known as TRE (TPA Responsive Element) or the AP-1 site.
M, Castellazzi, A, Sergeant
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Smaller Liver Tumors Without c-Jun
Science's STKE, 2003The transcription factor c-Jun controls both cell proliferation and cell survival, and not surprisingly, its activity has been linked to various human tumors. However, although it appears to be proapoptotic in some tumor types, it displays antiapoptotic activity in others, as seen in liver cancer. Eferl et al. found
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Inhibitors of c-jun-N-Terminal Kinase (JNK)
Mini-Reviews in Medicinal Chemistry, 2008Inhibitors of c-jun-N-Terminal Kinase (JNK) have many potential therapeutic indications ranging from neurodegenerative disease, to metabolic disorders, inflammation, cardiovascular disease, and cancer. This overview will highlight biological inhibitors such as JNK-interacting protein (JIP) as well as small molecule inhibitors from various structural ...
Philip, LoGrasso, Theodore, Kamenecka
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Alpha1‐antitrypsin deficiency and c‐JUN
Hepatology, 2017PONZETTO, Antonio +2 more
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C/EBPalpha downregualtes c-jun expression
2003Der Transkriptionsfaktor C/EBPa ist essentiell für die Differenzierung von Granulozyten. Die konditionelle Expression von C/EBPa induziert die neutrophile Differenzierung. Überdies kann C/EBPa die TPA-induzierte Differenzierung von myeloiden Vorläuferzellen zu Monozyten blockieren. In C/EBPa knockout Mäusen gibt es keine reifen Granulozyten.
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The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1
Cell, 1988Peter Angel, Michael Karin
exaly