Results 261 to 270 of about 521,522 (308)

NOS inhibition sensitizes metaplastic breast cancer to PI3K inhibition and taxane therapy via c-JUN repression. [PDF]

Nat Commun
Reddy T, Puri A, Guzman-Rojas L, Thomas C, Qian W, Zhou J, Zhao H, Mahboubi B, Oo A, Cho YJ, Kim B, Thaiparambil J, Rosato R, Martinez KO, Chervo MF, Ayerbe C, Giese N, Wink D, Lockett S, Wong S, Chang J, Krishnamurthy S, Yam C, Moulder S, Piwnica-Worms H, Meric-Bernstam F, Chang J.   +26 more
europepmc   +1 more source

Correction to "The Interleukin-1α Stimulated Expression of the Wrinkle-Inducing Elastase Neprilysin in Adult Human Dermal Fibroblasts Is Mediated via the Intracellular Signaling Axis of ERK/JNK/c-Jun/c-Fos/AP-1". [PDF]

J Dermatol
europepmc   +1 more source

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Phosphorylation of c-jun mediated by MAP kinases

Nature, 1991
The proto-oncogene c-jun is a component of the AP-1 transcription factor family involved in the mediation of nuclear events elicited by extracellular stimuli. The c-jun protein is negatively regulated by phosphorylation of residues near the carboxy terminus which are dephosphorylated in response to phorbol esters.
Joseph Avruch, Eleni Nikolakaki, James R Woodgett   +2 more
exaly   +3 more sources

Nucleolar localization of c‐Jun

The FEBS Journal, 2021
Nucleoli are well defined for their function in ribosome biogenesis, but only a small fraction of the nucleolar proteome has been characterized. Here, we report that the proto‐oncogene, c‐Jun, is targeted to the nucleolus. Using live cell imaging in myogenic cells, we document that the c‐Jun basic domain contains a unique, evolutionarily conserved ...
Tetsuaki Miyake, John C. McDermott
openaire   +2 more sources

NANOG upregulates c‐jun oncogene expression through binding the c‐jun promoter

Molecular Carcinogenesis, 2014
NANOG plays important roles in neoplastic processes. However, the molecular mechanism of NANOG in tumorigenesis remains to be elucidated. In this report, we demonstrated that forced expression of NANOG in 293 cells and cancer cells led to increased c‐Jun expression, whereas downregulation of endogenous NANOG significantly reduced c‐Jun expression in ...
Yanli, Lin, Fuyin, Xiong, Yanrong, Zhou, Xiaojie, Wu, Fang, Liu, Shiwei, Xue, Hongxing, Chen   +6 more
openaire   +2 more sources

c-Jun N-terminal kinase – c-Jun pathway transactivates Bim to promote osteoarthritis

Canadian Journal of Physiology and Pharmacology, 2014
Osteoarthritis (OA) is a chronic degenerative joint disorder. Previous studies have shown abnormally increased apoptosis of chondrocytes in patients and animal models of OA. TNF-α and nitric oxide have been reported to induce chondrocyte ageing; however, the mechanism of chondrocyte apoptosis induced by IL-1β has remained unclear.
Zhiqiang, Ye, Yuxian, Chen, Rongkai, Zhang, Haitao, Dai, Chun, Zeng, Hua, Zeng, Hui, Feng, Gengheng, Du, Hang, Fang, Daozhang, Cai   +9 more
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c‐Jun phosphorylation in Alzheimer disease

Journal of Neuroscience Research, 2007
AbstractThe c‐Jun N‐terminal kinase (JNK) pathway is known to be activated by oxidative stress and can lead to either defensive‐protective adaptations in the cell or apoptosis. The JNK pathway is activated in Alzheimer disease (AD), as demonstrated in studies showing higher levels of phospho‐JNK in affected neurons in AD brains than in controls. c‐Jun,
Akanksha, Thakur, Xinglong, Wang, Sandra L, Siedlak, George, Perry, Mark A, Smith, Xiongwei, Zhu   +5 more
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c-Fos Dimerization with c-Jun Represses c-Jun Enhancement of Androgen Receptor Transactivation

Endocrine, 1998
The transcriptional activity of the human androgen receptor (hAR), like other nuclear receptors, is dependent on accessory factors. One such factor is c-Jun, which has been shown to have a selective function of mediating androgen receptor-dependent transactivation.
K, Tillman, J L, Oberfield, X Q, Shen, A, Bubulya, L, Shemshedini   +4 more
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The Transformation of C-Jun-Overexpressing Cells Is Correlated with IGFS-Induced C-Jun Phosphorylation

Biochemical and Biophysical Research Communications, 1995
We have analyzed, in parental and c-jun-transfected rat liver epithelial (REL) cells, the capacity of the insulin-like growth factors (IGF1 and 2) to stimulate growth under anchorage dependent and independent conditions and the role of the c-jun protein in the response to these factors.
Lagarrigue, Sandrine, Heberden, Christine, Latino-Martel, Paule, Gaillard-Sanchez, I.   +3 more
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Transcriptional repression of c-Jun's E3 ubiquitin ligases contributes to c-Jun induction by UV

Cellular Signalling, 2008
UV radiation is a major environmental carcinogen. The oncoprotein c-Jun that is required for development of skin cancer is stabilized by UV radiation. The mechanism leading to its stabilization after exposure to UV is not known. The lack of knowledge was particularly sharpened, after the discovery that JNK, the most potent positive regulator of c-Jun ...
Shira, Anzi, Shlomo, Finkin, Eitan, Shaulian   +2 more
openaire   +2 more sources