Results 11 to 20 of about 69,600 (248)

The Dectin-2 family of C-type lectin-like receptors: an update. [PDF]

Int Immunol, 2013
Myeloid and non-myeloid cells express members of the C-type lectin-like receptor (CTLR) family, which mediate crucial cellular functions during immunity and homeostasis. Of relevance here is the dendritic cell-associated C-type lectin-2 (Dectin-2) family of CTLRs, which includes blood dendritic cell antigen 2 (BDCA-2), dendritic cell immunoactivating ...
Kerscher B, Willment JA, Brown GD.
europepmc   +7 more sources

C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways. [PDF]

Int Rev Immunol, 2013
Innate immunity is constructed around genetically encoded receptors that survey the intracellular and extracellular environments for signs of invading microorganisms. These receptors recognise the invader and through complex intracellular networks of molecular signaling, they destroy the threat whilst instructing effective adaptive immune responses ...
Plato A, Willment JA, Brown GD.
europepmc   +7 more sources

C-Type Lectin-like Receptor LOX-1 Promotes Dendritic Cell-Mediated Class-Switched B Cell Responses [PDF]

Immunity, 2014
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a pattern-recognition receptor for a variety of endogenous and exogenous ligands. However, LOX-1 function in the host immune response is not fully understood. Here, we report that LOX-1 expressed on dendritic cells (DCs) and B cells promotes humoral responses. On B cells LOX-1 signaling
Joo, HyeMee, Li, Dapeng, Dullaers, Melissa, Kim, Tae-Whan, Duluc, Dorothee, Upchurch, Katherine, Xue, Yaming, Zurawski, Sandy, Le Grand, Roger, Liu, Yong-Jun, Kuroda, Marcelo, Zurawski, Gerard, Oh, SangKon   +12 more
openaire   +6 more sources

Immunoregulatory Property of C-Type Lectin-Like Receptors in Fibrosing Interstitial Lung Diseases. [PDF]

Int J Mol Sci, 2020
The innate immune system identifies exogenous threats or endogenous stress through germline-encoded receptors called pattern recognition receptors (PRRs) that initiate consecutive downstream signaling pathways to control immune responses. However, the contribution of the immune system and inflammation to fibrosing interstitial lung diseases (ILD ...
Effendi WI, Nagano T, Hasan H, Yudhawati R.   +3 more
europepmc   +3 more sources

C-type lectin-like receptor 2: roles and drug target

Thrombosis Journal
C-type lectin-like receptor-2 (CLEC-2) is a member of the C-type lectin superfamily of cell surface receptors. The first confirmed endogenous and exogenous ligands of CLEC-2 are podoplanin and rhodocytin, respectively.
Lan Sun, Zhe Wang, Zhiyan Liu, Guangyan Mu, Yimin Cui, Qian Xiang   +5 more
doaj   +3 more sources

Production of recombinant soluble dimeric C-type lectin-like receptors of rat natural killer cells. [PDF]

Sci Rep, 2019
AbstractWorking at the border between innate and adaptive immunity, natural killer (NK) cells play a key role in the immune system by protecting healthy cells and by eliminating malignantly transformed, stressed or virally infected cells. NK cell recognition of a target cell is mediated by a receptor “zipper” consisting of various activating and ...
Vaněk O, Celadova P, Skořepa O, Bláha J, Kalousková B, Dvorská A, Poláchová E, Pucholtová H, Kavan D, Pompach P, Hofbauerová K, Kopecký V, Mesci A, Voigt S, Carlyle JR.   +14 more
europepmc   +6 more sources

Measurement of soluble C-type lectin-like receptor 2 in human plasma [PDF]

Platelets, 2015
Detection of platelet activation in vivo is useful to identify patients at risk of thrombotic diseases. Platelet factor 4 (PF4) and β-thromboglobulin (β-TG) are used for this purpose; however, they are easily released upon the minimal platelet activation that occurs during sampling.
Fuminori, Kazama, Junya, Nakamura, Makoto, Osada, Osamu, Inoue, Mitsuru, Oosawa, Shogo, Tamura, Nagaharu, Tsukiji, Kaoru, Aida, Akio, Kawaguchi, Soichi, Takizawa, Masahiro, Kaneshige, Shoichiro, Tanaka, Katsue, Suzuki-Inoue, Yukio, Ozaki   +13 more
  +8 more sources

Galectin‐9 activates platelet ITAM receptors glycoprotein VI and C‐type lectin‐like receptor‐2 [PDF]

Journal of Thrombosis and Haemostasis, 2022
Platelets are multifunctional cellular mediators in many physiological and pathophysiological processes such as thrombosis, angiogenesis, and inflammation. Several members of galectins, a family of carbohydrate-binding proteins with a broad range of immunomodulatory actions, have been reported to activate platelets.In this study, we investigated the ...
Zhaogong Zhi, Natalie J. Jooss, Yi Sun, Martina Colicchia, Alexandre Slater, Luis A. Moran, Hilaire Yam Fung Cheung, Ying Di, Julie Rayes, Natalie S. Poulter, Steve P. Watson, Asif J. Iqbal   +11 more
openaire   +2 more sources

Platelet C-Type Lectin-Like Receptor 2 Reduces Cholestatic Liver Injury in Mice [PDF]

The American Journal of Pathology, 2020
Cholestatic liver injury leads to liver dysfunction. The available evidence suggests that platelets can either promote or reduce liver injury and fibrosis. This study focused on the functions of the C-type lectin-like receptor 2 (CLEC-2), a new special platelet receptor that binds with podoplanin-activating platelets.
Suguru, Maruyama, Hiroshi, Kono, Shinji, Furuya, Hiroki, Shimizu, Ryo, Saito, Katsutoshi, Shoda, Hidenori, Akaike, Naohiro, Hosomura, Yoshihiko, Kawaguchi, Hidetake, Amemiya, Hiromichi, Kawaida, Makoto, Sudo, Shingo, Inoue, Toshiaki, Shirai, Katsue, Suzuki-Inoue, Daisuke, Ichikawa   +15 more
openaire   +2 more sources

Modulation of NK cell function by genetically coupled C-type lectin-like receptor/ligand pairs encoded in the human Natural Killer Gene Complex (NKC)

Frontiers in Immunology, 2013
Functional responses of Natural Killer (NK) cells including eradication of ‘harmful’ cells and modulation of immune responses are regulated by a broad variety of activating and inhibitory NK receptors. Whereas the leukocyte receptor complex (LRC) encodes
Yvonne eBartel, Björn eBauer, Alexander eSteinle   +2 more
doaj   +1 more source