Results 21 to 30 of about 69,600 (248)

Role of the C-type lectin receptors MCL and DCIR in experimental colitis. [PDF]

PLoS ONE, 2014
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract. Though its exact etiology is still unclear, it is proposed that an imbalance in the intestinal homeostasis leads to a disturbed interaction between ...
Julia Hütter, Magdalena Eriksson, Timo Johannssen, Robert Klopfleisch, Dorthe von Smolinski, Achim D Gruber, Peter H Seeberger, Bernd Lepenies   +7 more
doaj   +1 more source

C‐type lectin‐like receptors on myeloid cells

Annals of Medicine, 2006
Host defence against pathogens requires the recognition of conserved microbial molecules, or 'pathogen-associated molecular patterns' (PAMPs), by their receptors termed 'pattern recognition receptors' (PRRs), represented most notably by toll-like receptors (TLRs) and C-type lectins.
Elwira, Pyz, Andrew S J, Marshall, Siamon, Gordon, Gordon D, Brown   +3 more
openaire   +2 more sources

Association of arthritis with a gene complex encoding C‐type lectin–like receptors [PDF]

Arthritis & Rheumatism, 2007
AbstractObjectiveTo identify susceptibility genes in a rat model of rheumatoid arthritis (RA) and to determine whether the corresponding human genes are associated with RA.MethodsGenes influencing oil‐induced arthritis (OIA) were position mapped by comparing the susceptibility of inbred DA rats with that of DA rats carrying alleles derived from the ...
Johnny C, Lorentzen, Line, Flornes, Carina, Eklöw, Liselotte, Bäckdahl, Ulrica, Ribbhammar, Jian Ping, Guo, Marina, Smolnikova, Erik, Dissen, Maria, Seddighzadeh, Anthony J, Brookes, Lars, Alfredsson, Lars, Klareskog, Leonid, Padyukov, Sigbjörn, Fossum   +13 more
openaire   +2 more sources

Snake C-Type Lectin-Like Proteins and Platelet Receptors

Pathophysiology of Haemostasis and Thrombosis, 2005
Snake venoms are complex mixtures of biologically active proteins and peptides. Many affect haemostasis by activating or inhibiting coagulant factors or platelets, or by disrupting endothelium. Snake venom components are classified into various families, such as serine proteases, metalloproteinases, C-type lectin-like proteins, disintegrins and ...
Clemetson, Kenneth John, Lu, Qiumin, Clemetson, Jeannine   +2 more
openaire   +3 more sources

BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells. [PDF]

PLoS Biology, 2007
Dendritic cells are equipped with lectin receptors to sense the extracellular environment and modulate cellular responses. Human plasmacytoid dendritic cells (pDCs) uniquely express blood dendritic cell antigen 2 (BDCA2) protein, a C-type lectin lacking ...
Wei Cao, Li Zhang, David B Rosen, Laura Bover, Gokuran Watanabe, Musheng Bao, Lewis L Lanier, Yong-Jun Liu   +7 more
doaj   +1 more source

Nkrp1 Family, from Lectins to Protein Interacting Molecules

Molecules, 2015
The C-type lectin-like receptors include the Nkrp1 protein family that regulates the activity of natural killer (NK) cells. Rat Nkrp1a was reported to bind monosaccharide moieties in a Ca2+-dependent manner in preference order of GalNac > GlcNAc > ...
Daniel Rozbeský, Ljubina Ivanova, Lucie Hernychová, Valéria Grobárová, Petr Novák, Jan Černý   +5 more
doaj   +1 more source

Filoviruses: Innate Immunity, Inflammatory Cell Death, and Cytokines

Pathogens, 2022
Filoviruses are a group of single-stranded negative sense RNA viruses. The most well-known filoviruses that affect humans are ebolaviruses and marburgviruses. During infection, they can cause life-threatening symptoms such as inflammation, tissue damage,
Jianlin Lu, Jessica M. Gullett, Thirumala-Devi Kanneganti   +2 more
doaj   +1 more source

Evolution of the C-Type Lectin-Like Receptor Genes of the DECTIN-1 Cluster in the NK Gene Complex

The Scientific World Journal, 2012
Pattern recognition receptors are crucial in initiating and shaping innate and adaptive immune responses and often belong to families of structurally and evolutionarily related proteins.
Susanne Sattler, Hormas Ghadially, Erhard Hofer   +2 more
doaj   +1 more source

Role And Relevance Of Mast Cells In Fungal Infections

Frontiers in Immunology, 2012
In addition to their detrimental role in allergic diseases, mast cells (MCs) are well known to be important cells of the innate immune system. In the last decade, they have been shown to contribute significantly to optimal host defense against numerous ...
Rohit eSaluja, Martin eMetz, Marcus eMaurer   +2 more
doaj   +1 more source

C‐type lectin‐like CD161 is not a co‐signalling receptor in gluten‐reactive CD4 + T cells [PDF]

Scandinavian Journal of Immunology, 2021
AbstractC‐type lectin‐like CD161, a class II transmembrane protein, is a surface receptor expressed by NK cells and T cells. In coeliac disease, CD161 was expressed more frequently on gluten‐reactive CD4 + T cells compared to other memory CD4 + T cells isolated from the same tissue compartment.
Łukasz Wyrożemski, Ludvig M. Sollid, Shuo‐Wang Qiao   +2 more
openaire   +3 more sources