Results 11 to 20 of about 80,513 (237)
Signaling C-type lectin receptors in antimycobacterial immunity. [PDF]
PLoS Pathogens, 2017 The mammalian innate immune system is composed of phagocytes such as macrophages and dendritic cells that serve as the first line of defense against microbial infections. These cells express various pattern recognition receptors (PRRs) that recognize specific pathogen-associated molecular patterns (PAMPs) on the surface of or inside microorganisms [1].
Mohlopheni J Marakalala, Hlumani Ndlovu
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Targeting C-type Lectin Receptors for Cancer Immunity [PDF]
Frontiers in Immunology, 2015 C-type lectin receptors (CLRs) are a large family of soluble and trans-membrane pattern recognition receptors that are widely and primarily expressed on myeloid cells.
Huimin eYan +6 more
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C-type lectin receptors orchestrate antifungal immunity [PDF]
Nature Immunology, 2012 Immunity to pathogens critically requires pattern-recognition receptors (PRRs) to trigger intracellular signaling cascades that initiate and direct innate and adaptive immune responses. For fungal infections, these responses are primarily mediated by members of the C-type lectin receptor family.
Sarah E, Hardison, Gordon D, Brown
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Frontiers in Immunology, 2014 MCL (macrophage C-type lectin) and mincle (macrophage inducible C-type lectin) comprise part of an extensive repertoire of pattern recognition receptors with the ability to sense damage associated and pathogen associated molecular patterns.
Mark B Richardson, Spencer J Williams
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Signalling through C-type lectin receptors: shaping immune responses [PDF]
Nature Reviews Immunology, 2009 C-type lectin receptors (CLRs) expressed by dendritic cells are crucial for tailoring immune responses to pathogens. Following pathogen binding, CLRs trigger distinct signalling pathways that induce the expression of specific cytokines which determine T cell polarization fates.
Geijtenbeek, Teunis B. H. +1 more
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The Dectin-1 and Dectin-2 clusters: C-type lectin receptors with fundamental roles in immunity [PDF]
EMBO ReportsThe ability of myeloid cells to recognize and differentiate endogenous or exogenous ligands rely on the presence of different transmembrane protein receptors.
Mariano Malamud, Gordon D Brown
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The Interaction of Human Pathogenic Fungi With C-Type Lectin Receptors [PDF]
Frontiers in Immunology, 2018 Fungi, usually present as commensals, are a major cause of opportunistic infections in immunocompromised patients. Such infections, if not diagnosed or treated properly, can prove fatal.
Surabhi Goyal +5 more
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Limitations of a proper SFTSV mouse model using human C-type lectin receptors [PDF]
Frontiers in MicrobiologySevere fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus with a human mortality rate of up to 30%, posing a significant threat to public health. However, the lack of suitable research models has impeded the development of effective
You-Min Kim +11 more
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C-type lectin receptors in skin immunity: Emerging new role for CLEC12B
Advances in Biomedical and Health Sciences, 2022 C-type lectin receptors (CLRs) are a superfamily of transmembrane proteins, which consist of one or several C-type lectin-like domains and intracellular signaling motifs, such as immunoreceptor tyrosine-based activation motif (ITAM) or immunoreceptor ...
Lauriane Blot +2 more
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Myeloid C-Type Lectin Receptors in Viral Recognition and Antiviral Immunity [PDF]
Viruses, 2017 Recognition of viral glycans by pattern recognition receptors (PRRs) in innate immunity contributes to antiviral immune responses. C-type lectin receptors (CLRs) are PRRs capable of sensing glycans present in viral pathogens to activate antiviral immune ...
João T. Monteiro, Bernd Lepenies
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