Results 21 to 30 of about 131,185 (277)
Targeting C-type Lectin Receptors for Cancer Immunity [PDF]
Frontiers in Immunology, 2015 C-type lectin receptors (CLRs) are a large family of soluble and trans-membrane pattern recognition receptors that are widely and primarily expressed on myeloid cells.
Huimin eYan +6 more
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Differing Expression and Potential Immunological Role of C-Type Lectin Receptors of Two Different Chicken Breeds against Low Pathogenic H9N2 Avian Influenza Virus [PDF]
PathogensDiverse immune responses in different chicken lines can result in varying clinical consequences following avian influenza virus (AIV) infection. We compared two widely used layer breeds, Lohmann Brown (LB) and Lohmann White (LW), to examine virus ...
Sungsu Youk +2 more
doaj +2 more sources
C-type lectin receptors orchestrate antifungal immunity [PDF]
Nature Immunology, 2012 Immunity to pathogens critically requires pattern-recognition receptors (PRRs) to trigger intracellular signaling cascades that initiate and direct innate and adaptive immune responses. For fungal infections, these responses are primarily mediated by members of the C-type lectin receptor family.
Sarah E Hardison
exaly +3 more sources
A Proposal for Nomenclature in Myeloid C-Type Lectin Receptors [PDF]
Frontiers in Immunology, 2019 Myeloid C-type lectin receptors (CLRs) comprise a family of receptors expressed by immune myeloid cells that share homologous C-type lectin domains.
Carlos del Fresno +2 more
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Frontiers in Immunology, 2014 MCL (macrophage C-type lectin) and mincle (macrophage inducible C-type lectin) comprise part of an extensive repertoire of pattern recognition receptors with the ability to sense damage associated and pathogen associated molecular patterns.
Mark B Richardson, Spencer J Williams
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Signalling through C-type lectin receptors: shaping immune responses [PDF]
Nature Reviews Immunology, 2009 C-type lectin receptors (CLRs) expressed by dendritic cells are crucial for tailoring immune responses to pathogens. Following pathogen binding, CLRs trigger distinct signalling pathways that induce the expression of specific cytokines which determine T cell polarization fates.
Sonja Gringhuis
exaly +4 more sources
The Interaction of Human Pathogenic Fungi With C-Type Lectin Receptors [PDF]
Frontiers in Immunology, 2018 Fungi, usually present as commensals, are a major cause of opportunistic infections in immunocompromised patients. Such infections, if not diagnosed or treated properly, can prove fatal.
Surabhi Goyal +5 more
doaj +2 more sources
Limitations of a proper SFTSV mouse model using human C-type lectin receptors [PDF]
Frontiers in MicrobiologySevere fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus with a human mortality rate of up to 30%, posing a significant threat to public health. However, the lack of suitable research models has impeded the development of effective
You-Min Kim +11 more
doaj +2 more sources
C-type lectin receptors in skin immunity: Emerging new role for CLEC12B
Advances in Biomedical and Health Sciences, 2022 C-type lectin receptors (CLRs) are a superfamily of transmembrane proteins, which consist of one or several C-type lectin-like domains and intracellular signaling motifs, such as immunoreceptor tyrosine-based activation motif (ITAM) or immunoreceptor ...
Lauriane Blot +2 more
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Myeloid C-Type Lectin Receptors in Viral Recognition and Antiviral Immunity [PDF]
Viruses, 2017 Recognition of viral glycans by pattern recognition receptors (PRRs) in innate immunity contributes to antiviral immune responses. C-type lectin receptors (CLRs) are PRRs capable of sensing glycans present in viral pathogens to activate antiviral immune ...
João T. Monteiro, Bernd Lepenies
doaj +2 more sources