NOD1/2 and the C-Type Lectin Receptors Dectin-1 and Mincle Synergistically Enhance Proinflammatory Reactions Both In Vitro and In Vivo [PDF]
Journal of Inflammation Research, 2020 Amir I Tukhvatulin, Alina S Dzharullaeva, Alina S Erokhova, Dmitry V Scheblyakov, Boris S Naroditsky, Alexander L Gintsburg, Denis Y Logunov N. F. Gamaleya National Research Center for Epidemiology and Microbiology, Moscow, RussiaCorrespondence: Amir I ...
Tukhvatulin AI +6 more
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Frontiers in Immunology, 2018 Over the last decade, C-type lectin-like receptors (CTLRs), expressed mostly by myeloid cells, have gained increasing attention for their role in the fine tuning of both innate and adaptive immunity.
Elise Chiffoleau +3 more
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T Cell Antifungal Immunity and the Role of C-Type Lectin Receptors
Trends in Immunology, 2020 Fabian Salazar +2 more
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The Role of Lectin Receptors and Their Ligands in Controlling Allergic Inflammation
Frontiers in Immunology, 2021 More than fifty c-type lectin receptors (CLR) are known and have been identified so far. Moreover, we know the group of galectins and sialic acid-binding immunoglobulin-type lectins that also belong to the carbohydrate-binding receptors of the immune ...
Karin Peters, Marcus Peters
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Key thermally dimorphic fungal pathogens: shaping host immunity
Open Biology, 2022 Exposure to fungal pathogens from the environment is inevitable and with the number of at-risk populations increasing, the prevalence of invasive fungal infection is on the rise. An interesting group of fungal organisms known as thermally dimorphic fungi
Maxine A. Höft +2 more
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C-type Lectin Receptors for Tumor Eradication: Future Directions [PDF]
Cancers, 2011 Dendritic cells are key regulators in directing immune responses and therefore are under extensive research for the induction of anti-tumor responses. DCs express a large array of receptors by which they scan their surroundings for recognition and uptake of pathogens.
Streng-Ouwehand, Ingeborg +2 more
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Information transfer in mammalian glycan-based communication
eLife, 2023 Glycan-binding proteins, so-called lectins, are exposed on mammalian cell surfaces and decipher the information encoded within glycans translating it into biochemical signal transduction pathways in the cell.
Felix F Fuchsberger +6 more
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C-type lectin receptors orchestrate antifungal immunity [PDF]
Nature Immunology, 2012 Immunity to pathogens critically requires pattern-recognition receptors (PRRs) to trigger intracellular signaling cascades that initiate and direct innate and adaptive immune responses. For fungal infections, these responses are primarily mediated by members of the C-type lectin receptor family.
Sarah E, Hardison, Gordon D, Brown
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Lectin-dependent enhancement of Ebola virus infection via soluble and transmembrane C-type lectin receptors. [PDF]
PLoS ONE, 2013 Mannose-binding lectin (MBL) is a key soluble effector of the innate immune system that recognizes pathogen-specific surface glycans. Surprisingly, low-producing MBL genetic variants that may predispose children and immunocompromised individuals to ...
Matthew Brudner +22 more
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Computational and experimental prediction of human C-type lectin receptor druggability
Frontiers in Immunology, 2014 Mammalian C-type lectin receptors are involved in many aspects of immune cell regulation such as pathogen recognition, clearance of apoptotic bodies and lymphocyte homing.
Jonas eAretz +8 more
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