Results 31 to 40 of about 84,931 (265)

Key thermally dimorphic fungal pathogens: shaping host immunity

Open Biology, 2022
Exposure to fungal pathogens from the environment is inevitable and with the number of at-risk populations increasing, the prevalence of invasive fungal infection is on the rise. An interesting group of fungal organisms known as thermally dimorphic fungi
Maxine A. Höft, Lucian Duvenage, J. Claire Hoving   +2 more
doaj   +1 more source

Information transfer in mammalian glycan-based communication

eLife, 2023
Glycan-binding proteins, so-called lectins, are exposed on mammalian cell surfaces and decipher the information encoded within glycans translating it into biochemical signal transduction pathways in the cell.
Felix F Fuchsberger, Dongyoon Kim, Natalia Baranova, Hanka Vrban, Marten Kagelmacher, Robert Wawrzinek, Christoph Rademacher   +6 more
doaj   +1 more source

C-type lectin receptors orchestrate antifungal immunity [PDF]

Nature Immunology, 2012
Immunity to pathogens critically requires pattern-recognition receptors (PRRs) to trigger intracellular signaling cascades that initiate and direct innate and adaptive immune responses. For fungal infections, these responses are primarily mediated by members of the C-type lectin receptor family.
Sarah E, Hardison, Gordon D, Brown
openaire   +2 more sources

High glucose disrupts oligosaccharide recognition function via competitive inhibition : a potential mechanism for immune dysregulation in diabetes mellitus [PDF]

, 2011
Diabetic complications include infection and cardiovascular disease. Within the immune system, host-pathogen and regulatory host-host interactions operate through binding of oligosaccharides by C-type lectin.
Bee K. Tan, Robert B. Sim, Russell Wallis, Tan, Bee K., Elizabeth J. Soilleux, Townsend, Paul, Wallis, Russell, Soilleux, Elizabeth J., Paul Townsend, Daniel A. Mitchell, Randeva, Harpal S., Sim, Robert B., Hendrik Lehnert, Ilyas, Rebecca, Zehnder, Daniel, Mitchell, Daniel A., Daniel Zehnder, Rebecca Ilyas, Harpal S. Randeva, Lehnert, Hendrik   +19 more
core   +1 more source

Lectin-dependent enhancement of Ebola virus infection via soluble and transmembrane C-type lectin receptors. [PDF]

PLoS ONE, 2013
Mannose-binding lectin (MBL) is a key soluble effector of the innate immune system that recognizes pathogen-specific surface glycans. Surprisingly, low-producing MBL genetic variants that may predispose children and immunocompromised individuals to ...
Matthew Brudner, Marshall Karpel, Calli Lear, Li Chen, L Michael Yantosca, Corinne Scully, Ashish Sarraju, Anna Sokolovska, M Reza Zariffard, Damon P Eisen, Bruce A Mungall, Darrell N Kotton, Amel Omari, I-Chueh Huang, Michael Farzan, Kazue Takahashi, Lynda Stuart, Gregory L Stahl, Alan B Ezekowitz, Gregory T Spear, Gene G Olinger, Emmett V Schmidt, Ian C Michelow   +22 more
doaj   +1 more source

Computational and experimental prediction of human C-type lectin receptor druggability

Frontiers in Immunology, 2014
Mammalian C-type lectin receptors are involved in many aspects of immune cell regulation such as pathogen recognition, clearance of apoptotic bodies and lymphocyte homing.
Jonas eAretz, Jonas eAretz, Eike-Christian eWamhoff, Eike-Christian eWamhoff, Jonas eHanske, Jonas eHanske, Dario eHeymann, Christoph eRademacher, Christoph eRademacher   +8 more
doaj   +1 more source

Deletion of haematopoietic Dectin-2 or CARD9 does not protect from atherosclerosis development under hyperglycaemic conditions

Diabetes & Vascular Disease Research, 2020
Background: C-type lectin receptors, including Dectin-2, are pattern recognition receptors on monocytes and macrophages that mainly recognize sugars and sugar-like structures present on fungi.
Kathrin Thiem, Geerte Hoeke, Enchen Zhou, Anneke Hijmans, Tom Houben, Margien G Boels, Isabel M Mol, Esther Lutgens, Ronit Shiri-Sverdlov, Johan Bussink, Thirumala D Kanneganti, Mariëtte R Boon, Rinke Stienstra, Cees J Tack, Patrick CN Rensen, Mihai G Netea, Jimmy FP Berbée, Janna A van Diepen   +17 more
doaj   +1 more source

Differentiation-dependent glycosylation of cells in squamous cell epithelia detected by a mammalian lectin [PDF]

, 2002
The squamous stratified epithelia contain a proliferative (harboring mitotic activity) and a differentiating compartment. Due to the potential of protein-carbohyd rate interactions to regulate cellular activities we introduced a mammalian lectin to cyto-
Holíkova, Zuzana, Kaltner, Herbert, Motlik, Jan, Gabius, Hans-Joachim, Plzák, Jan, Smetana, Karel, Hercogová, Jana, Dvorankova, Barbora   +7 more
core   +1 more source

Modulation of NK cell function by genetically coupled C-type lectin-like receptor/ligand pairs encoded in the human Natural Killer Gene Complex (NKC)

Frontiers in Immunology, 2013
Functional responses of Natural Killer (NK) cells including eradication of ‘harmful’ cells and modulation of immune responses are regulated by a broad variety of activating and inhibitory NK receptors. Whereas the leukocyte receptor complex (LRC) encodes
Yvonne eBartel, Björn eBauer, Alexander eSteinle   +2 more
doaj   +1 more source

The Vi Capsular Polysaccharide of Salmonella Typhi Promotes Macrophage Phagocytosis by Binding the Human C-Type Lectin DC-SIGN

mBio, 2022
Capsular polysaccharides are common virulence factors of extracellular, but not intracellular bacterial pathogens, due to the antiphagocytic properties of these surface structures.
Lillian F. Zhang, Bernd Lepenies, Sayuri Nakamae, Briana M. Young, Renato L. Santos, Manuela Raffatellu, Brian A. Cobb, Hirotaka Hiyoshi, Andreas J. Bäumler   +8 more
doaj   +1 more source