Results 31 to 40 of about 80,513 (237)

Computational and experimental prediction of human C-type lectin receptor druggability

Frontiers in Immunology, 2014
Mammalian C-type lectin receptors are involved in many aspects of immune cell regulation such as pathogen recognition, clearance of apoptotic bodies and lymphocyte homing.
Jonas eAretz, Jonas eAretz, Eike-Christian eWamhoff, Eike-Christian eWamhoff, Jonas eHanske, Jonas eHanske, Dario eHeymann, Christoph eRademacher, Christoph eRademacher   +8 more
doaj   +1 more source

C-Type Lectin Receptors [PDF]

Immunology of the SkinBasic and Clinical Sciences in Skin Immune Responses, 2015
Kanazawa N.
europepmc   +3 more sources

The Vi Capsular Polysaccharide of Salmonella Typhi Promotes Macrophage Phagocytosis by Binding the Human C-Type Lectin DC-SIGN

mBio, 2022
Capsular polysaccharides are common virulence factors of extracellular, but not intracellular bacterial pathogens, due to the antiphagocytic properties of these surface structures.
Lillian F. Zhang, Bernd Lepenies, Sayuri Nakamae, Briana M. Young, Renato L. Santos, Manuela Raffatellu, Brian A. Cobb, Hirotaka Hiyoshi, Andreas J. Bäumler   +8 more
doaj   +1 more source

Modulation of NK cell function by genetically coupled C-type lectin-like receptor/ligand pairs encoded in the human Natural Killer Gene Complex (NKC)

Frontiers in Immunology, 2013
Functional responses of Natural Killer (NK) cells including eradication of ‘harmful’ cells and modulation of immune responses are regulated by a broad variety of activating and inhibitory NK receptors. Whereas the leukocyte receptor complex (LRC) encodes
Yvonne eBartel, Björn eBauer, Alexander eSteinle   +2 more
doaj   +1 more source

Comparative transcriptomics reveals the immune dynamics during the molting cycle of swimming crab Portunus trituberculatus

Frontiers in Immunology, 2022
Molting is one of the most important biological processes of crustacean species, and a number of molecular mechanisms facilitate this complex procedure. However, the understanding of the immune mechanisms underlying crustacean molting cycle remains very ...
Meimei Liu, Meimei Liu, Hongwei Ni, Xiaokang Zhang, Qiufeng Sun, Xugan Wu, Jie He   +6 more
doaj   +1 more source

cDNA Cloning and Expression Analysis of Pattern Recognition Proteins from the Chinese Oak Silkmoth, Antheraea pernyi

Insects, 2012
Pattern recognition receptors play an important role in insect immune defense. We cloned the β-1,3-glucan recognition protein, lectin-5 and C-type lectin 1 genes of Antheraea pernyi and examined the expression profiles of immune-stimulated pupae.
Wenli Li, Suyun Fang, Yuan Li, Fengjuan Li, Olle Terenius   +4 more
doaj   +1 more source

Characterisation of the bovine C-type lectin receptor Mincle and potential evidence for an endogenous ligand

Frontiers in Immunology, 2023
Innate immune receptors that form complexes with secondary receptors, activating multiple signalling pathways, modulate cellular activation and play essential roles in regulating homeostasis and immunity. We have previously identified a variety of bovine
Angela Holder, Jeannine Kolakowski, Chloe Rosentreter, Ellen Knuepfer, Sabine A. F. Jégouzo, Oliver Rosenwasser, Heather Harris, Lotta Baumgaertel, Amanda Gibson, Amanda Gibson, Dirk Werling   +10 more
doaj   +1 more source

Inhibitory C-type lectin receptors in myeloid cells

Immunology Letters, 2011
C-type lectin receptors encoded by the natural killer gene complex play critical roles in enabling NK cell discrimination between self and non-self. In recent years, additional genes at this locus have been identified with patterns of expression that extend to cells of the myeloid lineage where many of the encoded inhibitory receptors have equally ...
Redelinghuys, Pierre, Brown, Gordon D
openaire   +3 more sources

Evolution of the C-Type Lectin-Like Receptor Genes of the DECTIN-1 Cluster in the NK Gene Complex

The Scientific World Journal, 2012
Pattern recognition receptors are crucial in initiating and shaping innate and adaptive immune responses and often belong to families of structurally and evolutionarily related proteins.
Susanne Sattler, Hormas Ghadially, Erhard Hofer   +2 more
doaj   +1 more source

Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity [PDF]

Frontiers in Immunology, 2018
Of all the pathogen recognition receptor families, C-type lectin receptor (CLR)-induced intracellular signal cascades are indispensable for the initiation and regulation of antifungal immunity. Ongoing experiments over the last decade have elicited diverse CLR functions and novel regulatory mechanisms of CLR-mediated-signaling pathways. In this review,
Juan Tang, Guoxin Lin, Guoxin Lin, Wallace Y. Langdon, Lijian Tao, Jian Zhang   +5 more
openaire   +3 more sources