Results 31 to 40 of about 17,598 (187)

Nucleophosmin 1 associating with engulfment and cell motility protein 1 regulates hepatocellular carcinoma cell chemotaxis and metastasis

Open Medicine, 2023
The chemokine, C-X-C motif chemokine ligand 12 (CXCL12) and its G-protein-coupled receptor (GPCR) and C-X-C chemokine receptor type 4 (CXCR4), are closely associated with promoting hepatocellular carcinoma (HCC) chemotaxis and metastasis.
Yang Gangqi, Li Hongyan, Dong Zheng, Deng Kai, Lu Yinying   +4 more
doaj   +1 more source

C-X-C chemokine receptor CXCR4 mediates diurnal changes in the aggregation and dispersion of CD8⁺ T cells within the tumor microenvironment. [PDF]

Int J Cancer
What's new? In addition to governing daily variations in biological activity, the circadian clock regulates immune cell migration into tumors. Whether this influence extends to immune cell localization within the tumor microenvironment (TME) is unknown. Here, using cell and animal models, the authors investigated immune cell distribution within the TME
Tsuruta A, Fujimoto M, Hiraoka Y, Taniguchi A, Shiiba Y, Inoki T, Yamauchi T, Yoshida Y, Matsunaga N, Ohdo S, Koyanagi S.   +10 more
europepmc   +2 more sources

Prognostic and predictive value of circulating tumor cells and CXCR4 expression as biomarkers for a CXCR4 peptide antagonist in combination with carboplatin-etoposide in small cell lung cancer: exploratory analysis of a phase II study. [PDF]

, 2017
Background Circulating tumor cells (CTCs) and chemokine (C-X-C motif) receptor 4 (CXCR4) expression in CTCs and tumor tissue were evaluated as prognostic or predictive markers of CXCR4 peptide antagonist LY2510924 plus carboplatin-etoposide (CE) versus ...
Baeten, Kurt, Connelly, Mark C, D'Haese, David, Flynt, Amy, Gross, Steve, McCleod, Michael, Morano, Carrie, Peek, Victoria L, Polzer, John, Raddad, Eyas, Repollet, Madeline, Roberson, Stephanie, Salgia, Ravi, Sanders, Renouard, Spigel, David R, Stille, John R, Um, Suzane L, Weaver, R Waide, Wijayawardana, Sameera R, Yan, S Betty   +19 more
core   +1 more source

Senescent Tumor Cells Build a Cytokine Shield in Colorectal Cancer

Advanced Science, 2021
Cellular senescence can either support or inhibit cancer progression. Here, it is shown that intratumoral infiltration of CD8+ T cells is negatively associated with the proportion of senescent tumor cells in colorectal cancer (CRC).
Yong Won Choi, Young Hwa Kim, Seung Yeop Oh, Kwang Wook Suh, Young‐Sam Kim, Ga‐Yeon Lee, Jung Eun Yoon, Soon Sang Park, Young‐Kyoung Lee, Yoo Jung Park, Hong Seok Kim, So Hyun Park, Jang‐Hee Kim, Tae Jun Park   +13 more
doaj   +1 more source

What is the response profile of deciduous pulp fibroblasts stimulated with E. coli LPS and E. faecalis LTA?

BMC Immunology, 2020
Background Oral fibroblast immunological responses to bacterial stimuli are well known. However, there are few studies about pulp fibroblasts from deciduous teeth (HDPF) responses, which are important for the treatment of pulp infections in children. The
Bella Luna Colombini-Ishikiriama, Thiago Jose Dionisio, Thais Francini Garbieri, Rafaela Alves da Silva, Maria Aparecida Andrade Moreira Machado, Sandra Helena Penha de Oliveira, Vanessa Soares Lara, Andrew Seth Greene, Carlos Ferreira Santos   +8 more
doaj   +1 more source

Activation of fibroblast-like synoviocytes derived from rheumatoid arthritis via lysophosphatidic acid-lysophosphatidic acid receptor 1 cascade [PDF]

, 2014
INTRODUCTION: Lysophosphatidic acid (LPA) is a bioactive lipid that binds to G protein–coupled receptors (LPA(1–6)). Recently, we reported that abrogation of LPA receptor 1 (LPA(1)) ameliorated murine collagen-induced arthritis, probably via inhibition ...
Chie Miyabe, Chiyoko Sekine, Kazutaka Sugimoto, Masayoshi Harigai, Masayuki Miyasaka, Nobuyuki Miyasaka, Toshihiro Nanki, Waka Yokoyama, Yoshiko Iwai, Yoshishige Miyabe   +9 more
core   +1 more source

Caffeic Acid Phenethyl Ester Reduces the Adverse Effects of Nicotine on the Endometrium [PDF]

Iranian Journal of Medical Sciences, 2023
Background: Tobacco smoke contains various toxins that negatively affect the human reproductive system. Caffeic acid phenethyl ester (CAPE), a potent antioxidant, has protective effects on the reproductive system against oxygen-free radicals ...
Amin Namdari, Behnoosh Miladpour
doaj   +1 more source

Chemotactic Cues for NOTCH1-Dependent Leukemia [PDF]

, 2018
The NOTCH signaling pathway is a conserved signaling cascade that regulates many aspects of development and homeostasis in multiple organ systems.
Amadori, Alberto, Piovan, Erich, Tosello, Valeria, Zanovello, Paola   +3 more
core   +1 more source

miR-135a-5p alleviates morphine tolerance by targeting the regulation of CXCL12 expression [PDF]

Jichu yixue yu linchuang
Objective Investigating the effect of miR-135a-5p in regulating of CXCL12 on the formation of morphine tolerance in C57BL/6J mice. Methods Totally 64 mice were randomly divided into the following groups: control (NS) group, morphine tolerance (MT ...
HE Huamei, LU Wei
doaj   +1 more source

Roles of Major Chemokines in the Pathophysiology of Atrial Fibrillation

Cardiovascular Innovations and Applications
Chemokines are a subclass of cytokines, a large family of small secreted proteins that communicate via G protein-coupled heptahelical chemokine receptors on the cell surface.
Saira Rafaqat, Fozia Bibi, Muhammad Aqib Murad, Huma Khurshid, Amna Sheerin   +4 more
doaj   +1 more source