Results 11 to 20 of about 133,009 (166)
On collective behavior in <i>C. elegans</i>. [PDF]
Front NeurorobotC. elegans is a model organism in many biological domains, such as genetics, neurophysiology, and behavioral ecology. Despite our relatively deep knowledge of the neuronal, genetic and molecular mechanisms underlying C.
Antonic N, Vellinger A, Tuci E.
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Cells, 2023 The deubiquitinase BAP1 (BRCA1-associated protein 1) is associated with BAP1 tumor predisposition syndrome (TPDS). BAP1 is a tumor suppressor gene whose alterations in cancer are commonly caused by gene mutations leading to protein loss of function.
Carmen Martínez-Fernández +5 more
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Disease Models & Mechanisms, 2022 Cisplatin is the most common drug in first-line chemotherapy against solid tumors. We and others have previously used the nematode Caenorhabditis elegans to identify genetic factors influencing the sensitivity and resistance to cisplatin.
Carmen Martínez-Fernández +8 more
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Toxicology Reports, 2023 Caenorhabditis elegans represents a favorite non-mammalian animal model, which is often used to study the effect of foreign substances on living organisms. Its epidermal barrier is a primary biological barrier that protects nematodes from the toxicity of
Soňa Kucharíková +4 more
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Gastrulation in C. elegans [PDF]
WormBook, 2005 Gastrulation is the process by which the germ layers become positioned in an embryo. C. elegans gastrulation serves as a model for studying the molecular mechanisms of diverse cellular and developmental phenomena, including morphogenesis, cell polarization, cell-cell signaling, actomyosin contraction and cell-cell adhesion.
Jeremy, Nance +2 more
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Genome editing in animals with minimal PAM CRISPR-Cas9 enzymes
Nature Communications, 2022 PAM requirement is a constraint for genome editing but this has been circumvented by engineered Cas9 nucleases as SpG and SpRY recognizing minimal PAM sequences.
Jeremy Vicencio +16 more
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AKIR-1 regulates proteasome subcellular function in Caenorhabditis elegans
iScience, 2023 Summary: Polyubiquitinated proteins are primarily degraded by the ubiquitin-proteasome system (UPS). Proteasomes are present both in the cytoplasm and nucleus. Here, we investigated mechanisms coordinating proteasome subcellular localization and activity
Johanna Pispa +6 more
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WormBook, 2009 Autophagy is a ubiquitous cellular process responsible for the bulk degradation of cytoplasmic components through an autophagosomal-lysosomal pathway. Genetic screens, primarily in S. cerevisiae, have identified numerous genes that are essential for autophagy. Many of these genes have orthologs in higher eukaryotes, including C.
Alicia, Meléndez, Beth, Levine
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WormBook, 2005 MicroRNAs (miRNAs) are small, non-coding regulatory RNAs found in many phyla that control such diverse events as development, metabolism, cell fate and cell death. They have also been implicated in human cancers. The C. elegans genome encodes hundreds of miRNAs, including the founding members of the miRNA family lin-4 and let-7.
Monica C, Vella, Frank J, Slack
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Saudi Pharmaceutical Journal, 2021 The use of many psychotropic drugs (PDs) is associated with increased caloric intake, significant weight gain, and metabolic disorders. The nematode Caenorhabditis elegans (C. elegans) has been used to study the effects of PDs on food intake.
Abdullah Almotayri +5 more
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