Results 101 to 110 of about 70,452 (309)
PLoS Neglected Tropical Diseases, 2020 Besides the common Fc receptor (FcR)-mediated mechanism of antibody-dependent enhancement (ADE), Ebola virus (EBOV) is known to utilize the complement component C1q for ADE of infection.
Wakako Furuyama +4 more
semanticscholar +1 more source
Expression and Function of C1q Receptors and C1q Binding Proteins at the Cell Surface
Immunobiology, 2002 C1q is the recognition unit of the first component of complement that binds not only IgG and IgM containing immune complexes, but also recognizes foreign structures such as the lipid A of endotoxin, and molecules expressed at the surface of apoptotic cells. In this review, the plasma membrane receptors and binding proteins for C1q are discussed and new
Shivraj Tyagi +3 more
openaire +3 more sources
Immunobiology, 2007 C1q is the target recognition protein of the classical complement pathway and a major connecting link between innate and acquired immunity. As a charge pattern recognition molecule of innate immunity, C1q can engage a broad range of self and non-self ligands via its heterotrimeric globular (gC1q) domain and thus trigger the classical pathway.
Ghai, R +7 more
openaire +3 more sources
Research progress of neurovascular units involved in ischemic stroke
Ibrain, EarlyView.The brain receives less blood when an ischemic stroke develops, which damages neurons and leads to an increased release of Pro‐inflammatory mediators that activate neurovascular unit (NVU). When the tight junctions are broken and the basement membrane is disrupted by matrix metalloproteinases produced by active endothelial and pericellular cells ...
Yu Yang +4 more
wiley +1 more source
Scientific Reports, 2017 C1q collagen-like region (CLR) engaging and activating the LAIR-1 inhibitory immunoreceptor represents a non-complement mechanism for maintaining immune quiescence.
Myoungsun Son +5 more
doaj +1 more source
Frontiers in Immunology, 2016 The complement system plays an important role in the innate and acquired immune response against pathogens. It consists of more than 30 proteins found in soluble form or attached to cell membranes. Most complement proteins circulate in inactive forms and
Lourdes eIsaac, Ana Catarina Lunz Macedo
doaj +1 more source
New trend in molecular diagnostics: Insights from the tumor microenvironment
Interdisciplinary Medicine, EarlyView.The graphical abstract outline the key elements in TME‐based molecular diagnostics, including biomarker exploration, diagnostic methods, and diagnostic models. Source: Created with BioRender.com. Abstract Molecular diagnosis has revolutionized cancer precision medicine.
Baiyuan Fan +3 more
wiley +1 more source
Emerging and novel functions of complement protein C1q
Frontiers in Immunology, 2015 Complement protein C1q, the recognition subcomponent of the classical pathway, performs a diverse range of complement and non-complement functions. It can bind various ligands derived from self, non-self and altered-self and modulate the functions of ...
Lubna eKouser +6 more
doaj +1 more source
Complement C1q as a Potential Biomarker for Obesity and Metabolic Syndrome in Chinese Adolescents
Frontiers in Endocrinology, 2020 BackgroundComplement C1q (C1q) has been confirmed to be related to obesity, metabolic syndrome (MetS), and its components. However, human data regarding the associations are relatively scarce.
Xuelian Yang +4 more
doaj +1 more source
Structural features of human immunoglobulin G that determine isotype-specific differences in complement activation. [PDF]
, 1993 Although very similar in sequence, the four subclasses of human immunoglobulin G (IgG) differ markedly in their ability to activate complement. Glu318-Lys320-Lys322 has been identified as a key binding motif for the first component of complement, C1q ...
Morrison, SL, Smith, RI, Tao, MH
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