Results 101 to 110 of about 68,566 (325)

Elevated Serum Complement C1q Levels After Traumatic Brain Injury and Its Association with Poor Prognosis

Neuropsychiatric Disease and Treatment, 2022
Xin-Jiang Yan,1 Yang-Bo Li,1 Wei Liu,1 Hua-Yong Wu,2 Guo-Feng Yu1 1Department of Neurosurgery, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Quzhou, People’s Republic of China; 2Neurosurgical Intensive Care Unit,
Yan XJ, Li YB, Liu W, Wu HY, Yu GF
doaj  

Clinical impact of complement (C1q, C3d) binding De Novo donor-specific HLA antibody in kidney transplant recipients. [PDF]

PLoS ONE, 2018
INTRODUCTION:Complement binding activity of donor-specific HLA antibodies (DSA) has been suggested as a new tool to stratify immunologic risk in kidney transplantation (KT).
Hyeyoung Lee, Eunhee Han, Ae-Ran Choi, Tae Hyun Ban, Byung Ha Chung, Chul Woo Yang, Yeong Jin Choi, Eun-Jee Oh   +7 more
doaj   +1 more source

Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor

Brain : a journal of neurology, 2019
See Cunha (doi:10.1093/brain/awz335) for a scientific commentary on this article. Carvalho et al. provide clues to the onset of immune dysregulation underlying early synaptic loss in Alzheimer’s disease and tauopathies, by linking overactivation of ...
Kevin Carvalho, E. Faivre, Marie J Pietrowski, X. Marques, Victoria Gomez-Murcia, Aude Deleau, V. Huin, J. N. Hansen, S. Kozlov, C. Danis, Mariana Temido-Ferreira, J. Coelho, C. Mériaux, S. Eddarkaoui, S. Gras, Mélanie Dumoulin, Lucrezia Cellai, I. Landrieu, Y. Chern, M. Hamdane, L. Buée, A. Boutillier, S. Lévi, A. Halle, Luísa V. Lopes, D. Blum   +25 more
semanticscholar   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Complement Component C1q and Anti‐C1q Antibodies in Theory and in Clinical Practice [PDF]

Scandinavian Journal of Immunology, 2008
AbstractThe complement system is a major part of the innate immunity. The first component of the classical pathway of complement activation, C1q, plays a crucial role in the clearance of immune complexes and apoptotic bodies from the organism. Autoantibodies against C1q (anti‐C1q) have been found in a number of autoimmune and infectious diseases.
P. Kralikova, E. Potlukova
openaire   +3 more sources

Implications of C1q/TNF-related protein superfamily in patients with coronary artery disease. [PDF]

, 2020
The C1q complement/TNF-related protein superfamily (CTRPs) displays differential effects on the regulation of metabolic homeostasis, governing cardiovascular function.
Cao, Jimin, Guo, Rui, Jia, Yongping, Jiao, Xiangying, Lau, Wayne Bond, Liu, Caihong, Liu, Jing, Liu, Wenxia, Ma, Xin-Liang, Wang, Yajing, Xu, Kun, Yan, Zheyi, Zhang, Yanwei   +12 more
core   +1 more source

SERPINB3 delays glomerulonephritis and attenuates the lupus-like disease in lupus murine models by inducing a more tolerogenic immune phenotype [PDF]

, 2018
Objective: To explore the effects of SERPINB3 administration in murine lupus models with a focus on lupus-like nephritis. Methods: 40 NZB/W F1 mice were subdivided into 4 groups and intraperitoneally injected with recombinant SERPINB3 (7.5 \u3bcg/0.1 mL ...
Beggio, M, Biasiolo, A, Cappon, A, Cavicchioli, L, Codolo, G, Doria, A., Gatto, M, Ghirardello, A, Luisetto, R, Maggioni, G, Pontisso, P, Saccon, F, Venturini, R   +12 more
core   +2 more sources

Paracrine Orchestration of Tumor Microenvironment Remodeling Induced by GLO1 Potentiates Lymph Node Metastasis in Breast Cancer

Advanced Science, EarlyView.
Single‐cell RNA sequencing of lymph node (LN) samples is performed, and a comprehensive landscape of the entire ecosystem is generated. Paracrine orchestration of TME remodeling induced by GLO1 potentiates LN metastasis in breast cancer. This study offers novel perspectives on the microenvironment remodeling of breast cancer LN metastases, suggesting ...
Jindong Xie, Wenjian Liu, Xinpei Deng, Huan Wang, Xueqi Ou, Xin An, Min‐Yi Situ, Anli Yang, Chuan Peng, Rongfang He, Yi Xie, Hailin Tang, Yuman Chen, Jie‐Ying Liang, Ruonan Shao, Weikai Xiao, Shaoquan Zheng   +16 more
wiley   +1 more source

C1q-Mediated Complement Activation and C3 Opsonization Trigger Recognition of Stealth Poly(2-methyl-2-oxazoline)-Coated Silica Nanoparticles by Human Phagocytes.

ACS Nano, 2018
Poly(2-methyl-2-oxazoline) (PMOXA) is an alternative promising polymer to poly(ethylene glycol) (PEG) for design and engineering of macrophage-evading nanoparticles (NPs).
R. Tavano, L. Gabrielli, E. Lubian, C. Fedeli, S. Visentin, P. Polverino de Laureto, G. Arrigoni, A. Geffner-Smith, Fangfang Chen, D. Simberg, G. Morgese, E. M. Benetti, LinPing Wu, S. Moghimi, F. Mancin, E. Papini   +15 more
semanticscholar   +1 more source

Expression and Function of C1q Receptors and C1q Binding Proteins at the Cell Surface

Immunobiology, 2002
C1q is the recognition unit of the first component of complement that binds not only IgG and IgM containing immune complexes, but also recognizes foreign structures such as the lipid A of endotoxin, and molecules expressed at the surface of apoptotic cells. In this review, the plasma membrane receptors and binding proteins for C1q are discussed and new
Shivraj Tyagi, Ionita Ghiran, Anne Nicholson-Weller, Lloyd B. Klickstein   +3 more
openaire   +3 more sources