Results 131 to 140 of about 68,566 (325)
Cancer Communications, EarlyView.Abstract Background Colorectal cancer liver metastasis (CRLM) is characterized by an immunosuppressive microenvironment and a blunted response to immunotherapy. Notably, tumor‐associated macrophages (TAMs) play a critical role in modulating immune responses and exhibit significant heterogeneity in CRLM.
Yizhi Zhan +11 more
wiley +1 more source
Elevated Serum Complement C1q Levels After Traumatic Brain Injury [Letter]
Neuropsychiatric Disease and Treatment, 2022 Wellingson Silva Paiva,1,2 Josimar Ortiz,1 Robson Luis Amorim2 1Division of Neurosurgery, Department of Neurology, Hospital das Clínicas da Faculdade de Medicina, University of São Paulo, São Paulo, Brazil; 2LIM 62, Laboratory of ...
Paiva WS, Ortiz J, Amorim RL
doaj
Frontiers in Immunology, 2018 Complement component C1q plays an important recognition role in adaptive, and innate, immunity through its ability to interact, via its six globular head regions, with both immunoglobulin and non-immunoglobulin activators of the complement system, and ...
K. Reid
semanticscholar +1 more source
Glia, EarlyView.Multiple sclerosis involves chronic CNS inflammation and neurodegeneration. This review highlights glial cells as key drivers in progressive MS, focusing on lesion pathology, molecular dysfunction, and human‐relevant model systems. ABSTRACT Multiple sclerosis (MS) is the most common non‐infectious inflammatory CNS disease, characterized by progressive ...
Volker Siffrin
wiley +1 more source
Prognostic Implications of the Complement Protein C1q in Gliomas
Frontiers in Immunology, 2019 The contribution of the complement system in the pathophysiology of brain cancers has been recently considered in light of its well-known involvement in carcinogenesis.
A. Mangogna +10 more
semanticscholar +1 more source
Building Immunocompetent Cerebral Organoids From a Developmental Perspective
Glia, EarlyView.Conventional cerebral organoids do not contain microglia, which must be added. We propose recommendations to assess microglial immunocompetence using quantitative approaches and stringent statistical analysis to help develop standardized protocols. ABSTRACT Cerebral organoids derived from human induced pluripotent stem cells (iPSCs) are increasingly ...
Xabier Cuesta‐Puente +8 more
wiley +1 more source
Research progress of neurovascular units involved in ischemic stroke
Ibrain, EarlyView.The brain receives less blood when an ischemic stroke develops, which damages neurons and leads to an increased release of Pro‐inflammatory mediators that activate neurovascular unit (NVU). When the tight junctions are broken and the basement membrane is disrupted by matrix metalloproteinases produced by active endothelial and pericellular cells ...
Yu Yang +4 more
wiley +1 more source
Scientific Reports, 2017 C1q collagen-like region (CLR) engaging and activating the LAIR-1 inhibitory immunoreceptor represents a non-complement mechanism for maintaining immune quiescence.
Myoungsun Son +5 more
doaj +1 more source
C1q+ macrophages: passengers or drivers of cancer progression.
Trends in Cancer, 2022 M. Revel +3 more
semanticscholar +1 more source
Molecular Psychiatry, 2018 TYROBP/DAP12 forms complexes with ectodomains of immune receptors (TREM2, SIRPβ1, CR3) associated with Alzheimer’s disease (AD) and is a network hub and driver in the complement subnetwork identified by multi-scale gene network studies of postmortem ...
M. Audrain +13 more
semanticscholar +1 more source