Results 131 to 140 of about 70,452 (309)
Cellular Mechanism and Key Insights in Allergen Immunotherapy for Allergic Rhinitis
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Allergic rhinitis (AR) arises from immune responses mediated by immunoglobulin E (IgE) to inhaled allergens, representing one of the most prevalent chronic conditions worldwide. Although AR may not be a serious ailment, it holds clinical relevance as it underpins numerous complications, serves as a major risk factor for suboptimal asthma ...
Zhe Wang +3 more
wiley +1 more source
Tkachenko polarons in vortex lattices
, 2013 We analyze the properties of impurities immersed in a vortex lattice formed by ultracold bosons in the mean field quantum Hall regime. In addition to the effects of a periodic lattice potential, the impurity is dressed by collective modes with parabolic ...
Bagnato, V. S. +2 more
core +1 more source
Aging Cell, EarlyView.Brain DNA methylation drives abnormal gene expression in AppNL‐G‐F mice. Perinatal choline supplementation may promote resilience to synaptic dysfunction through modulation of DNA methylation. ABSTRACT Alzheimer's disease (AD) is the most common type of dementia.
Andre Krunic +7 more
wiley +1 more source
Aging Cell, EarlyView.Targeting muscle with Cathepsin B (Ctsb) to treat the AD mouse brain. In this study, an AAV‐vector‐mediated approach, utilized to express Ctsb in muscle, prevented mnemonic and neurogenic deficits and normalized hippocampal, muscle, and plasma proteomic profiles.
Alejandro Pinto +16 more
wiley +1 more source
Ocular Dominance Plasticity in Binocular Primary Visual Cortex Does Not Require C1q
Journal of Neuroscience, 2019 C1q, the initiator of the classical complement cascade, mediates synapse elimination in the postnatal mouse dorsolateral geniculate nucleus of the thalamus and sensorimotor cortex.
Christina A. Welsh +3 more
semanticscholar +1 more source
Allergy, EarlyView.SCF and TSLP expression are known to drive unique immune responses leading to the onset of allergic and inflammatory diseases. Here, we describe the characterization of a novel bsAb, CDX‐622, that targets SCF and TSLP. CDX‐622 inhibits MC functions through SCF starvation and Type 2 inflammatory responses via TSLP inhibition.
Michael B. Murphy +17 more
wiley +1 more source
Neuropsychiatric Disease and Treatment, 2022 Xin-Jiang Yan,1 Yang-Bo Li,1 Wei Liu,1 Hua-Yong Wu,2 Guo-Feng Yu1 1Department of Neurosurgery, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Quzhou, People’s Republic of China; 2Neurosurgical Intensive Care Unit,
Yan XJ, Li YB, Liu W, Wu HY, Yu GF
doaj
miR-132 regulates the expression of synaptic proteins in APP/PS1 transgenic mice through C1q
European Journal of Histochemistry, 2019 Cognitive impairment in Alzheimer’s disease (AD) is usually accompanied by synaptic loss in both the hippocampus and neocortex. In the early stage of AD, amyloid β-induced synapse changes is the main reason, while in the later stage, the accumulation of ...
Nan Xu +5 more
semanticscholar +1 more source
C1q and Systemic Lupus Erythematosus
Immunobiology, 1998 In this chapter we review the association between SLE and C1q. In the first part of the chapter we discuss the clinical associations of C1q deficiency, and tabulate the available information in the literature relating to C1q deficiency and autoimmune disease.
Marina Botto +2 more
openaire +3 more sources