Results 141 to 150 of about 68,566 (325)
Journal of Clinical Laboratory Analysis, EarlyView.Raised anti‐C1q antibody titres in South Africans with SLE were associated with active LN, as evidenced by an active urine sediment. A positive anti‐C1q antibody and low serum C1q were associated with a positive Direct Coombs' test. ABSTRACT Objective To investigate prevalence and clinical correlates of serum C1q and anti‐C1q antibody titres in black ...
Mohammed Tikly +2 more
wiley +1 more source
Ocular Dominance Plasticity in Binocular Primary Visual Cortex Does Not Require C1q
Journal of Neuroscience, 2019 C1q, the initiator of the classical complement cascade, mediates synapse elimination in the postnatal mouse dorsolateral geniculate nucleus of the thalamus and sensorimotor cortex.
Christina A. Welsh +3 more
semanticscholar +1 more source
Engineering Efferocytosis for Bone Regeneration
Macromolecular Bioscience, EarlyView.The repair of bone tissue in acute and chronic injuries is a significant long‐standing clinical challenge. Biomaterials‐based interventions are well‐positioned to interrogate mechanisms of efferocytosis due to their ability to provide support and guide cellular activity.
Jacob Miszuk, Linna Zhong, Hongli Sun
wiley +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Adiponectin, a member of the CTRP family of secreted proteins produced by adipose tissue, is thought to function as an endocrine hormone. An unusual feature of adiponectin is that it is present in high concentrations in circulation and thus ...
Jessica J Ye +3 more
semanticscholar +1 more source
Recent Advancements in the Treatment of Age‐Related Macular Degeneration
Med Research, EarlyView.ABSTRACT Age‐related macular degeneration (AMD) is a prevalent cause of visual impairment and blindness among the elderly. AMD can be categorized into two subtypes: “wet” and “dry.” Current treatments for wet AMD mainly involve anti‐vascular endothelial growth factor (VEGF) drugs, and there are three U.S.
Shan Liu +10 more
wiley +1 more source
Causal Link and Shared Biomarkers Between Rheumatoid Arthritis and Idiopathic Pulmonary Fibrosis
Med Research, EarlyView.ABSTRACT This study investigates the causal relationship between rheumatoid arthritis (RA) and idiopathic pulmonary fibrosis (IPF), aiming to identify shared biomarkers between the two conditions. Utilizing bidirectional Mendelian randomization (MR), we assessed causality by analyzing genome‐wide association study (GWAS) data from European cohorts ...
Xixi Pan +5 more
wiley +1 more source
C1q and Systemic Lupus Erythematosus
Immunobiology, 1998 In this chapter we review the association between SLE and C1q. In the first part of the chapter we discuss the clinical associations of C1q deficiency, and tabulate the available information in the literature relating to C1q deficiency and autoimmune disease.
Marina Botto +2 more
openaire +3 more sources
Neuroprotection, EarlyView.Mechanistic crosstalk between microglia and astrocytes in major depressive disorder. Abstract Major depressive disorder (MDD) is a complex psychiatric condition increasingly linked to chronic neuroinflammation, particularly in the context of aging, stress, and systemic comorbidities.
Gaurav Singhal +2 more
wiley +1 more source
Complement Component C1q as Serum Biomarker to Detect Active Tuberculosis
Frontiers in Immunology, 2018 Background: Tuberculosis (TB) remains a major threat to global health. Currently, diagnosis of active TB is hampered by the lack of specific biomarkers that discriminate active TB disease from other (lung) diseases or latent TB infection (LTBI ...
R. Lubbers +19 more
semanticscholar +1 more source
Serum amyloid P aids complement-mediated immunity to Streptococcus pneumoniae [PDF]
, 2007 The physiological functions of the acute phase protein serum amyloid P (SAP) component are not well defined, although they are likely to be important, as no natural state of SAP deficiency has been reported.
Botto, M. +3 more
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