Results 141 to 150 of about 70,452 (309)

A Case of Palmoplantar Vesiculobullous Lesions

JEADV Clinical Practice, EarlyView.
Ali Abid, Kelvin Truong, Jing Jing Li, Artiene Tatian   +3 more
wiley   +1 more source

P2X7 receptor antagonism suppresses epileptiform‐like activity in an inflammation‐primed human iPSC‐derived neuron model of drug‐resistant epilepsy

British Journal of Pharmacology, EarlyView.
Background and Purpose Neuroinflammation is increasingly recognised to contribute to drug‐resistant epilepsy. Activation of ATP‐gated P2X7 receptors has emerged as an important upstream mechanism, and increased P2X7 receptor expression is present in the seizure focus in rodent models and patients. Pharmacological antagonists of P2X7 receptors attenuate
Jaideep Kesavan, Yitao Wang, Klaus Dinkel, Michael Hamacher, Jochen H. M. Prehn, David C. Henshall, Tobias Engel   +6 more
wiley   +1 more source

Elevated Serum Complement C1q Levels After Traumatic Brain Injury [Letter]

Neuropsychiatric Disease and Treatment, 2022
Wellingson Silva Paiva,1,2 Josimar Ortiz,1 Robson Luis Amorim2 1Division of Neurosurgery, Department of Neurology, Hospital das Clínicas da Faculdade de Medicina, University of São Paulo, São Paulo, Brazil; 2LIM 62, Laboratory of ...
Paiva WS, Ortiz J, Amorim RL
doaj  

Isolation and characterization of C1q, a subcomponent of the first component of complement, from human and rabbit sera [PDF]

, 1972
K.B.M. Reid, Diane M. Lowe, Roy Porter
openalex   +1 more source

Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau

Molecular Psychiatry, 2018
TYROBP/DAP12 forms complexes with ectodomains of immune receptors (TREM2, SIRPβ1, CR3) associated with Alzheimer’s disease (AD) and is a network hub and driver in the complement subnetwork identified by multi-scale gene network studies of postmortem ...
M. Audrain, Jean-Vianney Haure-Mirande, Minghui Wang, SoongHo Kim, T. Fanutza, Paramita Chakrabarty, P. Fraser, P. S. St George-Hyslop, T. Golde, R. Blitzer, E. Schadt, Bin Zhang, M. Ehrlich, S. Gandy   +13 more
semanticscholar   +1 more source

Adiponectin and related C1q/TNF-related proteins bind selectively to anionic phospholipids and sphingolipids

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Adiponectin, a member of the CTRP family of secreted proteins produced by adipose tissue, is thought to function as an endocrine hormone. An unusual feature of adiponectin is that it is present in high concentrations in circulation and thus ...
Jessica J Ye, X. Bian, Jaechul Lim, R. Medzhitov   +3 more
semanticscholar   +1 more source

Status quo and future developments in the diagnosis and treatment of hereditary angioedema

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Hereditary angioedema (HAE) is a rare hereditary disease characterized by edema, which can be life‐threatening in case of swelling in the larynx. The most common form of HAE is caused by a mutation of the SERPING1 gene and is characterized by a deficiency (type I) or loss of function (type II) of the C1 inhibitor (C1‐INH), leading to excessive ...
Andreas Recke
wiley   +1 more source

Binding of von Willebrand Factor to Complement C1q Decreases the Phagocytosis of Cholesterol Crystals and Subsequent IL-1 Secretion in Macrophages

Frontiers in Immunology, 2019
Complement C1q, the initiation molecule of the classical pathway, exerts various immunomodulatory functions independent of complement activation. Non-classical functions of C1q include the clearance of apoptotic cells and cholesterol crystals (CC), as ...
Claudia Donat, Sophia Thanei, Marten Trendelenburg, Marten Trendelenburg   +3 more
doaj   +1 more source

Detection of antibody-dependent complement mediated inactivation of both autologous and heterologous virus in primary HIV-1 infection [PDF]

, 2005
Specific CD8 T-cell responses to human immunodeficiency virus type 1 (HIV-1) are induced in primary infection and make an important contribution to the control of early viral replication.
Aasa-Chapman, M.M.I., Aubin, K., Borrow, P., Cornforth, D., Holuigue, S., Jones, N.A., McKnight, A., Newton, P., Pellegrino, P., Williams, I., Wong, M.   +10 more
core  

C1q (C1) Receptor on Human Platelets: Inhibition of Collagen-Induced Platelet Aggregation by C1q (C1) Molecules [PDF]

, 1976
E.A. Suba, György Csákó
openalex   +1 more source