Results 21 to 30 of about 70,452 (309)
Change in C1q deposition in C1q nephropathy [PDF]
Pediatric Nephrology, 2009 Sirs, We read with interest the article entitled “A single-center study of C1q nephropathy in children” by Roberti et al. in the latest issue of this journal [1]. They reviewed the records of 14 children with C1q nephropathy (C1qN) and found a high incidence in pediatric patients (14/264, 5.3%), with variable clinical presentation.
Ken Hatae +4 more
openaire +3 more sources
Clinical & Translational Immunology, 2022 Objectives Systemic lupus erythematosus (SLE) is a clinically heterogeneous autoimmune disease with complex pathogenic mechanisms. Complement C1q has been shown to play a major role in SLE, and autoantibodies against C1q (anti‐C1q) are strongly ...
Pascal Alexander Rabatscher +1 more
doaj +1 more source
Understanding the contextual functions of C1q and LAIR-1 and their applications
Experimental and Molecular Medicine, 2022 The importance of the complement component C1q has been highlighted by its involvement in autoimmunity, infection, inflammatory diseases, and tumors.
Myoungsun Son
semanticscholar +1 more source
Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury
Science, 2021 Description Neuroinflammation after brain injury Traumatic brain injury affects millions of people every year and is a major cause of disability worldwide.
Stephanie S. Holden +18 more
semanticscholar +1 more source
The Humoral Theory of Transplantation: Epitope Analysis and the Pathogenicity of HLA Antibodies. [PDF]
, 2016 Central to the humoral theory of transplantation is production of antibodies by the recipient against mismatched HLA antigens in the donor organ. Not all mismatches result in antibody production, however, and not all antibodies are pathogenic.
Farber, John, Filippone, Edward J
core +8 more sources
C1q binding to surface-bound IgG is stabilized by C1r2s2 proteases
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Antibody-dependent complement activation plays a major role in various pathophysiological processes in our body, including infection, inflammation, autoimmunity, and transplant rejection.
S. Zwarthoff +18 more
semanticscholar +1 more source
Frontiers in Immunology, 2020 To investigate the fine epitope(s) of anti-C1q A08 antibodies and their roles in complement activation in lupus nephritis, C1q A08 and related peptides with various amino acid sequences around A08 were synthesized.
Wen-Jun Wu +23 more
doaj +1 more source
Frontiers in Immunology, 2021 Elements of the immune system particularly that of innate immunity, play important roles beyond their traditional tasks in host defense, including manifold roles in the nervous system.
R. Kovács +16 more
semanticscholar +1 more source
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
Genome Biology, 2021 Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers due to its high metastasis rate in the liver. However, little is known about the molecular features of hepatic metastases due to difficulty in obtaining fresh tissues and low tumor
JianYu Yang +15 more
semanticscholar +1 more source