Results 21 to 30 of about 57,775 (215)
Frontiers in Oncology, 2015 The immune system protects against disease, but may aberrantly silence immunity against altered self, with consequent development of malignancies. Among the components of the endoplasmic reticulum (ER), important in immunity, is calreticulin (CRT) that ...
GALIA eRAMIREZ-TOLOZA +4 more
doaj +1 more source
SLE: Novel Postulates for Therapeutic Options
Frontiers in Immunology, 2020 Genetic deficiency in C1q is a strong susceptibility factor for systemic lupus erythematosus (SLE). There are two major hypotheses that potentially explain the role of C1q in SLE.
Kinga K. Hosszu +3 more
doaj +1 more source
Review of presentations at the 6th European Lupus Meeting 3-5 March 2005. [PDF]
, 2005 The 6th European Lupus Meeting was held at the Royal College of Physicians of London and was attended by 450 delegates. The conference brought together leading speakers from Europe and North America who reviewed current knowledge and exciting new ...
Bowman, SJ +3 more
core +1 more source
Hepatology Communications, 2022 Complement complex 1 subunit q (C1q) has multiple functions, including cell migration, in addition to its traditional complement‐activating effect. Research shows C1q is a ligand for frizzled receptors (FZDs).
Akiko Eguchi +10 more
doaj +1 more source
The human C1q globular domain: Structure and recognition of non immune self ligands
Frontiers in Immunology, 2012 C1q, the ligand binding unit of the C1 complex of complement, is a pattern recognition molecule with the unique ability to sense an amazing variety of targets, including a number of altered structures from self, such as apoptotic cells.
Christine eGaboriaud +3 more
doaj +1 more source
The collagen structure of C1q induces wound healing by engaging discoidin domain receptor 2
Molecular Medicine, 2021 Background C1q has been reported to reveal complement-independent roles in immune and non-immune cells. C1q binds to its specific receptors to regulate distinct functions that rely on the environment and cell types.
Ria Aryani Hayuningtyas +9 more
doaj +1 more source
Marine Drugs, 2019 C1q-domain-containing (C1qDC) proteins are rapidly emerging as key players in the innate immune response of bivalve mollusks. Growing experimental evidence suggests that these highly abundant secretory proteins are involved in the recognition of microbe ...
Marco Gerdol +2 more
doaj +1 more source
Frontiers in Immunology, 2016 The heterotrimeric globular head (gC1q) domain of human C1q is made up of the C-terminal ends of the three individual chains, ghA, ghB and ghC. The receptor for the gC1q domain is a multi-functional pattern recognition protein, gC1qR. Since understanding
Lina Pednekar +12 more
doaj +1 more source
Complement C1q Enhances Primary Hemostasis [PDF]
Frontiers in Immunology, 2020 The cross-talk between the inflammatory complement system and hemostasis is becoming increasingly recognized. The interaction between complement C1q, initiation molecule of the classical pathway, and von Willebrand factor (vWF), initiator molecule of primary hemostasis, has been shown to induce platelet rolling and adhesion in vitro.
Claudia Donat +6 more
openaire +3 more sources
Effective dynamics of double solitons for perturbed mKdV [PDF]
, 2010 We show that an interacting double soliton solution to the perturbed mKdV equation is close in $H^2$ to a double soliton following an effective dynamics obtained as Hamilton's equations for the restriction of the mKdV Hamiltonian to the submanifold of ...
Holmer, Justin +2 more
core +5 more sources