Results 21 to 30 of about 68,566 (325)
Blood, 2022 Key Points • C1Q+ cells represent a highly tissue-infiltrative leukemia population and could reconstitute EMI phenotype of AML.• Fibroblast attracts C1Q+ leukemia cell via C1Q–globular C1Q receptor recognition and stimulation of transforming growth ...
Li-Xue Yang +18 more
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Understanding the contextual functions of C1q and LAIR-1 and their applications
Experimental and Molecular Medicine, 2022 The importance of the complement component C1q has been highlighted by its involvement in autoimmunity, infection, inflammatory diseases, and tumors.
Myoungsun Son
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Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury
Science, 2021 Description Neuroinflammation after brain injury Traumatic brain injury affects millions of people every year and is a major cause of disability worldwide.
Stephanie S. Holden +18 more
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A non-redundant role of complement protein C1q in normal and adverse pregnancy
Exploration of Immunology, 2022 Complement component 1q (C1q) is the recognition molecule of the classical pathway of the complement system that can bind to an array of closely spaced antigen-bound immunoglobulin G (IgG) and IgM antibodies.
Chiara Agostinis +4 more
doaj +1 more source
C1q binding to surface-bound IgG is stabilized by C1r2s2 proteases
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Antibody-dependent complement activation plays a major role in various pathophysiological processes in our body, including infection, inflammation, autoimmunity, and transplant rejection.
S. Zwarthoff +18 more
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Clinical & Translational Immunology, 2022 Objectives Systemic lupus erythematosus (SLE) is a clinically heterogeneous autoimmune disease with complex pathogenic mechanisms. Complement C1q has been shown to play a major role in SLE, and autoantibodies against C1q (anti‐C1q) are strongly ...
Pascal Alexander Rabatscher +1 more
doaj +1 more source
Genome Biology, 2021 Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers due to its high metastasis rate in the liver. However, little is known about the molecular features of hepatic metastases due to difficulty in obtaining fresh tissues and low tumor
JianYu Yang +15 more
semanticscholar +1 more source
Frontiers in Immunology, 2021 Elements of the immune system particularly that of innate immunity, play important roles beyond their traditional tasks in host defense, including manifold roles in the nervous system.
R. Kovács +16 more
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Glia, 2021 The classical complement cascade mediates synapse elimination in the visual thalamus during early brain development. However, whether the primary visual cortex also undergoes complement‐mediated synapse elimination during early visual system development ...
Qifei Cong +5 more
semanticscholar +1 more source
Complement, C1q, and C1q-Related Molecules Regulate Macrophage Polarization [PDF]
Frontiers in Immunology, 2014 Complement is a critical system of enzymes, regulatory proteins, and receptors that regulates both innate and adaptive immune responses. Natural mutations in complement molecules highlight their requirement in regulation of a variety of human conditions including infectious disease and autoimmunity.
Suzanne S. Bohlson +4 more
openaire +4 more sources