Results 31 to 40 of about 68,566 (325)

CD93 is Selectively Expressed on Human Myeloma Cells but Not on B Lymphocytes [PDF]

Iranian Journal of Immunology, 2019
Background: CD93 has originally been known as a C1q receptor, and many studies have demonstrated that CD93 is expressed on hematopoietic stem cells, B cell progenitors, myeloid and monocytic cells.
Shohreh Fakhari, Hamed Bashiri, Bayazid Ghaderi, Kaveh Tari, Ali Jalili   +4 more
doaj   +1 more source

Development of C1q Affinity Chromatography for the Study of C1q–IgG Interactions

The Journal of Immunology, 2023
Abstract The classical complement system represents a central effector mechanism of Abs initiated by the binding of C1q to target bound IgG. Human C1q contains six heterotrimeric globular head groups that mediate IgG interaction, resulting in an avidity-driven binding event involving multiple IgG molecules binding a single C1q ...
Michael J E Marshall, Alexander Knaupp, Christian Spick, Ilker Koese, Maria Maier, Mark S Cragg, Florian Cymer, Tilman Schlothauer   +7 more
openaire   +4 more sources

Peptide inhibitor of complement C1 (PIC1), a novel suppressor of classical pathway activation: mechanistic studies and clinical potential

Frontiers in Immunology, 2014
The classical pathway of complement plays multiple physiological roles including modulating immunological effectors initiated by adaptive immune responses as well as an essential homeostatic role in the clearance of damaged self-antigens.
Julia A Sharp, Pamela H. Whitley, Kenji M. Cunnion, Kenji M. Cunnion, Neel Kumar Krishna, Neel Kumar Krishna   +5 more
doaj   +1 more source

C1q A08 Is a Half-Cryptic Epitope of Anti-C1q A08 Antibodies in Lupus Nephritis and Important for the Activation of Complement Classical Pathway

Frontiers in Immunology, 2020
To investigate the fine epitope(s) of anti-C1q A08 antibodies and their roles in complement activation in lupus nephritis, C1q A08 and related peptides with various amino acid sequences around A08 were synthesized.
Wen-Jun Wu, Wen-Jun Wu, Wen-Jun Wu, Wen-Jun Wu, Wen-Jun Wu, Wen-Jun Wu, Ying Tan, Ying Tan, Ying Tan, Ying Tan, Xiao-Ling Liu, Xiao-Ling Liu, Xiao-Ling Liu, Xiao-Ling Liu, Feng Yu, Feng Yu, Feng Yu, Feng Yu, Feng Yu, Ming-Hui Zhao, Ming-Hui Zhao, Ming-Hui Zhao, Ming-Hui Zhao, Ming-Hui Zhao   +23 more
doaj   +1 more source

A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes (*)

Journal of Biological Chemistry, 1995
We describe a novel 30-kDa secretory protein, Acrp30 (adipocyte complement-related protein of 30 kDa), that is made exclusively in adipocytes and whose mRNA is induced over 100-fold during adipocyte differentiation.
P. Scherer, Suzanne E. Williams, M. Fogliano, G. Baldini, H. Lodish   +4 more
semanticscholar   +1 more source

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica, Devin K. Binder, Meinrad Drexel, Chrysanthy Ikonomidou, Shilpa D. Kadam, Guenther Sperk, Christian Steinhäuser   +6 more
wiley   +1 more source

Gut-derived bacterial vesicles carrying lipopolysaccharide promote microglia-mediated synaptic pruning. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Growing evidence links gut microbiota (GM) to Alzheimer's disease (AD). Elevated lipopolysaccharide (LPS) levels, a Gram‐negative bacteria component, are found in AD brains, but how LPS breaches the blood–brain barrier (BBB) remains unclear.
Zhao X, Yu J, Xu B, Xu Z, Lei X, Han S, Luo S, Zhang C, Peng G, Li J, Yu J, Ling Y, Fan Z, Mo W, Yang Y, Zhang J.   +15 more
europepmc   +2 more sources

Is it all that bad when living with an intracellular protozoan? The role of Trypanosoma cruzi calreticulin in angiogenesis and tumor growth

Frontiers in Oncology, 2015
The immune system protects against disease, but may aberrantly silence immunity against altered self, with consequent development of malignancies. Among the components of the endoplasmic reticulum (ER), important in immunity, is calreticulin (CRT) that ...
GALIA eRAMIREZ-TOLOZA, LORENA eAGUILAR-GUZMAN, CAROLINA eVALCK, PAULA eABELLO, LUIS ARTURO FERREIRA   +4 more
doaj   +1 more source

Review of presentations at the 6th European Lupus Meeting 3-5 March 2005. [PDF]

, 2005
The 6th European Lupus Meeting was held at the Royal College of Physicians of London and was attended by 450 delegates. The conference brought together leading speakers from Europe and North America who reviewed current knowledge and exciting new ...
Bowman, SJ, Giles, IP, Ioannou, Y, Rahman, A   +3 more
core   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source