Results 41 to 50 of about 57,775 (215)

Cardiac-derived CTRP9 protects against myocardial ischemia/reperfusion injury via calreticulin-dependent inhibition of apoptosis. [PDF]

, 2018
Cardiokines play an essential role in maintaining normal cardiac functions and responding to acute myocardial injury. Studies have demonstrated the heart itself is a significant source of C1q/TNF-related protein 9 (CTRP9). However, the biological role of
Feng, Pan, Gao, Erhe, Lau, Wayne Bond, Ma, Xin-Liang, Qin, Zhigang, Sun, Yang, Tan, Yanzhen, Xu, Xuezeng, Yang, Jian, Yi, Dinghua, Yi, Wei, Yu, Shiqiang, Zhang, Zhengbin, Zhao, Dajun   +13 more
core   +2 more sources

Development of C1q Affinity Chromatography for the Study of C1q–IgG Interactions

The Journal of Immunology, 2023
Abstract The classical complement system represents a central effector mechanism of Abs initiated by the binding of C1q to target bound IgG. Human C1q contains six heterotrimeric globular head groups that mediate IgG interaction, resulting in an avidity-driven binding event involving multiple IgG molecules binding a single C1q ...
Michael J E Marshall, Alexander Knaupp, Christian Spick, Ilker Koese, Maria Maier, Mark S Cragg, Florian Cymer, Tilman Schlothauer   +7 more
openaire   +4 more sources

Clinical significance of serum complement C1q in diagnosis of malignant tumors

陆军军医大学学报, 2023
Objective To investigate the serum level of complement C1q in patients with malignant tumors and its clinical significance in the diagnosis of the tumors. Methods A retrospective analysis was conducted on 468 patients with malignant tumors (including 164
WANG Yunlong, LI Hongsen, WU Lixiang
doaj   +1 more source

The complement system at the embryo implantation site: friend or foe?

Frontiers in Immunology, 2012
An inflammatory-like process and vascular remodeling represent the main changes that occur in decidua in the early phase of pregnancy. These changes are partly induced by trophoblast cells that colonize the decidua and are also contributed by the ...
Roberta eBulla, Fleur eBossi, Francesco eTedesco   +2 more
doaj   +1 more source

The many roles of C1q [PDF]

eLife, 2020
The ability of a well-known component of the complement cascade to bind to a variety of receptors has implications for signaling biology, spinal cord injury and, possibly, the evolution of the complement system.
Mark Noble, Christoph Pröschel
openaire   +3 more sources

C1q as a target molecule to treat human disease: What do mouse studies teach us?

Frontiers in Immunology, 2022
The complement system is a field of growing interest for pharmacological intervention. Complement protein C1q, the pattern recognition molecule at the start of the classical pathway of the complement cascade, is a versatile molecule with additional non ...
Kristina Schulz, Kristina Schulz, Marten Trendelenburg, Marten Trendelenburg   +3 more
doaj   +1 more source

Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes. [PDF]

, 2012
BACKGROUND The intricate interactions between the immune, endocrine and central nervous systems shape the innate immune response of the brain. We have previously shown that estradiol suppresses expression of immune genes in the frontal cortex of ...
Carl Cotman, Erik Hrabovszky, Imre Kalló, István Likó, Miklós Sárvári, Nicole Berchtold, Norbert Solymosi, Sárvári, Miklós, Zsolt Liposits   +8 more
core   +2 more sources

Anti-C1q autoantibodies, novel tests and clinical consequences

Frontiers in Immunology, 2013
Although anti-C1q autoantibodies have been described more than four decades ago a constant stream of papers describing clinical associations or functional consequences highlights that anti-C1q antibodies are still hot and happening.
Michael eMahler, Rosanne evan Schaarenburg, Leendert eTrouw   +2 more
doaj   +1 more source

Decidual endothelial cells express surface-bound C1q as a molecular bridge between endovascular trophoblast and decidual endothelium [PDF]

, 2008
This study was prompted by the observation that decidual endothelial cells (DECs), unlike endothelial cells (ECs) of blood vessels in normal skin, kidney glomeruli and brain, express surface-bound C1q in physiologic pregnancy. This finding was unexpected,
Agostinis, C., Bossi, F., Bulla, R., De Seta, F., Debeus, A., Ghebrehiwet, B., Radillo, O., Rizzi, L., Tedesco, F., TRIPODO, Claudio   +9 more
core   +1 more source

C1q Levels: A Reliable Biomarker for Differentiating Active and Latent Tuberculosis Infection

International Journal of Mycobacteriology
Background: Tuberculosis (TB) poses a significant public health challenge, particularly because it can exist in an asymptomatic latent phase. Latent TB infection indicates the presence of Mycobacterium tuberculosis without clinical symptoms.
Sepideh Darougar, Afshin Moniri, Parvaneh Baghaei, Esmaeil Mortaz, Makan Sadr, Arad Moniri, Majid Marjani, Payam Tabarsi   +7 more
doaj   +1 more source