Results 51 to 60 of about 62,354 (276)

Monocyte expressed macromolecular C1 and C1q receptors as molecular sensors of danger: Implications in SLE.

Frontiers in Immunology, 2014
The ability of circulating blood monocytes to express C1q receptors (cC1qR and gC1qR)synthesize and secrete the classical pathway proteins C1q, C1r and C1s and their regulator, C1-INH is very well established.
Berhane eGhebrehiwet, Kinga K Hosszu, Alisa M Valentino, Yan eJi, Ellinor I.B. Peerschke   +4 more
doaj   +1 more source

A central role for C1q/TNF-related protein 13 (CTRP13) in modulating food intake and body weight. [PDF]

, 2013
C1q/TNF-related protein 13 (CTRP13), a hormone secreted by adipose tissue (adipokines), helps regulate glucose metabolism in peripheral tissues. We previously reported that CTRP13 expression is increased in obese and hyperphagic leptin-deficient mice ...
Byerly, Mardi S, McCulloh, Patrick S, Seldin, Marcus M, Swanson, Roy, Wei, Zhikui, Wong, G William   +5 more
core   +2 more sources

The complement system at the embryo implantation site: friend or foe?

Frontiers in Immunology, 2012
An inflammatory-like process and vascular remodeling represent the main changes that occur in decidua in the early phase of pregnancy. These changes are partly induced by trophoblast cells that colonize the decidua and are also contributed by the ...
Roberta eBulla, Fleur eBossi, Francesco eTedesco   +2 more
doaj   +1 more source

Epitope-Specific Anti-C1q Autoantibodies in Systemic Lupus Erythematosus

Frontiers in Immunology, 2022
ObjectiveIn patients with systemic lupus erythematosus (SLE) complement C1q is frequently targeted by autoantibodies (anti-C1q), that correlate best with active renal disease. Anti-C1q bind to largely unknown epitopes on the collagen-like region (CLR) of
Jessica S. Kleer, Jessica S. Kleer, Pascal A. Rabatscher, Jessica Weiss, Joel Leonardi, Joel Leonardi, Severin B. Vogt, Andrea Kieninger-Gräfitsch, Carlo Chizzolini, Uyen Huynh-Do, Camillo Ribi, Marten Trendelenburg, Marten Trendelenburg   +12 more
doaj   +1 more source

Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines. [PDF]

, 2012
The integrated control of animal physiology requires intimate tissue crosstalk, a vital task mediated by circulating humoral factors. As one type of these factors, adipose tissue-derived adipokines have recently garnered attention as important regulators
Seldin, Marcus M, Wong, G William
core   +1 more source

C1q as a target molecule to treat human disease: What do mouse studies teach us?

Frontiers in Immunology, 2022
The complement system is a field of growing interest for pharmacological intervention. Complement protein C1q, the pattern recognition molecule at the start of the classical pathway of the complement cascade, is a versatile molecule with additional non ...
Kristina Schulz, Kristina Schulz, Marten Trendelenburg, Marten Trendelenburg   +3 more
doaj   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Human C1q Induces Apoptosis in an Ovarian Cancer Cell Line via Tumor Necrosis Factor [PDF]

, 2016
Copyright: © 2016 Kaur, Sultan, Murugaiah, Pathan, Alhamlan, Karteris and Kishore. Human C1q is the first recognition subcomponent of the complement classical pathway that plays a vital role in the clearance of immune complexes, pathogens and apoptotic ...
Alhamlan, F, Karteris, E, Kaur, A, Kishore, U, Murugaiah, V, Pathan, AA, Sultan, SHA   +6 more
core   +1 more source

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source

C1q Levels: A Reliable Biomarker for Differentiating Active and Latent Tuberculosis Infection

International Journal of Mycobacteriology
Background: Tuberculosis (TB) poses a significant public health challenge, particularly because it can exist in an asymptomatic latent phase. Latent TB infection indicates the presence of Mycobacterium tuberculosis without clinical symptoms.
Sepideh Darougar, Afshin Moniri, Parvaneh Baghaei, Esmaeil Mortaz, Makan Sadr, Arad Moniri, Majid Marjani, Payam Tabarsi   +7 more
doaj   +1 more source