Results 51 to 60 of about 68,566 (325)

Innate immunity and neuroinflammation [PDF]

, 2013
Copyright © 2013 Abhishek Shastri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Bonifati, DM, Kishore, U, Shastri, A
core   +3 more sources

Decidual endothelial cells express surface-bound C1q as a molecular bridge between endovascular trophoblast and decidual endothelium [PDF]

, 2008
This study was prompted by the observation that decidual endothelial cells (DECs), unlike endothelial cells (ECs) of blood vessels in normal skin, kidney glomeruli and brain, express surface-bound C1q in physiologic pregnancy. This finding was unexpected,
Agostinis, C., Bossi, F., Bulla, R., De Seta, F., Debeus, A., Ghebrehiwet, B., Radillo, O., Rizzi, L., Tedesco, F., TRIPODO, Claudio   +9 more
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The Solution Structures of Two Human IgG1 Antibodies Show Conformational Stability and Accommodate Their C1q and FcγR Ligands. [PDF]

, 2015
The human IgG1 antibody subclass shows distinct properties compared with the IgG2, IgG3, and IgG4 subclasses and is the most exploited subclass in therapeutic antibodies. It is the most abundant subclass, has a half-life as long as that of IgG2 and IgG4,
Abe, Andrusier, Ashish, Ashton, Boehm, Brekke, Bruhns, Brüggemann, Calmettes, Collins, Dall'Acqua, Dangl, Davies, Deisenhofer, Diebolder, Dorai, Feinstein, Furtado, Gaboriaud, Gar Kay Hui, Garcia de la Torre, García De La Torre, Glatter, Gregory, Guddat, Guex, Hamilton, Harris, Harris, Heenan, Hezareh, Hughes-Jones, Idusogie, Isenman, Iwura, Jayesh Gor, Jefferis, Kilár, Klein, Laue, Lilyestrom, Lucy E. Rayner, Lund, Luo, Manning, Marquart, Michaelsen, Narayanan, Paul A. Dalby, Perkins, Perkins, Perkins, Perkins, Phillips, Pilz, Radaev, Radaev, Rayner, Rayner, Remmele, Richard K. Heenan, Richardson, Roux, Saphire, Saphire, Sarma, Schneider, Schneidman-Duhovny, Schuck, Schuck, Semenyuk, Sondermann, Stephen J. Perkins, Strohl, Sun, Tamm, Tao, Thommesen, Wang, Yang   +79 more
core   +1 more source

Clinical significance of serum complement C1q in diagnosis of malignant tumors

陆军军医大学学报, 2023
Objective To investigate the serum level of complement C1q in patients with malignant tumors and its clinical significance in the diagnosis of the tumors. Methods A retrospective analysis was conducted on 468 patients with malignant tumors (including 164
WANG Yunlong, LI Hongsen, WU Lixiang
doaj   +1 more source

ApoE attenuates unresolvable inflammation by complex formation with activated C1q

Nature Network Boston, 2019
Apolipoprotein-E (ApoE) has been implicated in Alzheimer’s disease, atherosclerosis, and other unresolvable inflammatory conditions but a common mechanism of action remains elusive.
C. Yin, Susanne Ackermann, Zhe Ma, Sarajo K. Mohanta, Chuankai Zhang, Yuanfang Li, S. Nietzsche, M. Westermann, Li Peng, D. Hu, Sai Vineela Bontha, P. Srikakulapu, Michael Beer, R. Megens, S. Steffens, M. Hildner, L. D. Halder, H. Eckstein, J. Pelisek, J. Herms, S. Roeber, T. Arzberger, A. Borodovsky, Livia Habenicht, C. Binder, C. Weber, P. Zipfel, C. Skerka, A. Habenicht   +28 more
semanticscholar   +1 more source

Tumor Cells Hijack Macrophage-Produced Complement C1q to Promote Tumor Growth

Cancer immunology research, 2019
The density of C1q-producing TAMs and C4d deposits, hallmarks of complement activation, are negative prognostic factors in human clear-cell renal cell carcinoma.
L. Roumenina, Marie V. Daugan, Rémi Noé, F. Petitprez, Y. Vano, R. Sanchez-Salas, E. Becht, J. Meilleroux, Bénédicte Le Clec'h, Nicolas A. Giraldo, N. Merle, Cheng-Ming Sun, V. Verkarre, P. Validire, J. Selves, L. Lacroix, O. Delfour, I. Vandenberghe, C. Thuilliez, S. Keddani, Imene B. Sakhi, E. Barret, P. Ferré, N. Corvaïa, A. Passioukov, E. Chetaille, M. Botto, A. de Reyniès, S. Oudard, A. Méjean, X. Cathelineau, C. Sautès-Fridman, W. Fridman   +32 more
semanticscholar   +1 more source

The Humoral Theory of Transplantation: Epitope Analysis and the Pathogenicity of HLA Antibodies. [PDF]

, 2016
Central to the humoral theory of transplantation is production of antibodies by the recipient against mismatched HLA antigens in the donor organ. Not all mismatches result in antibody production, however, and not all antibodies are pathogenic.
Farber, John, Filippone, Edward J
core   +4 more sources

The regulatory roles of C1q

Immunobiology, 2007
C1q binds to immune complexes to elicit complement-dependent microbial killing and enhance phagocytosis. Besides this classical role, C1q also opsonizes apoptotic cells for clearance by phagocytes. C1q deficiency increases susceptibility to microbial infections and is also associated with elevated autoimmunity as characterized by increased apoptotic ...
Lu, J., Wu, X., Teh, B.K.
openaire   +2 more sources

Is the anti-tumor property of Trypanosoma cruzi infection mediated by its Calreticulin?

Frontiers in Immunology, 2016
Eight to 10 million people in 21 endemic countries are infected with Trypanosoma cruzi. However, only 30% of those infected develop symptoms of Chagas’ disease, a chronic, neglected tropical disease worldwide. Similar to other pathogens, T.
Galia Andrea Ramírez-Toloza, Paula Abello, Arturo Ferreira   +2 more
doaj   +1 more source

A longitudinal study of C1q and anti-C1q autoantibodies in homologous and heterologous pregnancies for predicting pre-eclampsia

Frontiers in Immunology, 2022
C1q, the recognition molecule of the classical pathway of the complement system, plays a central role in pregnancy. Lack of C1q is characterized by poor trophoblast invasion and pregnancy failure.
Chiara Agostinis, Gabriella Zito, Miriam Toffoli, Isabel Peterlunger, Livia Simoni, Andrea Balduit, Erica Curtolo, Alessandro Mangogna, Beatrice Belmonte, Davide Vacca, Federico Romano, Tamara Stampalija, Tamara Stampalija, Tiziana Salviato, Federica Defendi, Nicoletta Di Simone, Nicoletta Di Simone, Uday Kishore, Giuseppe Ricci, Giuseppe Ricci, Roberta Bulla   +20 more
doaj   +1 more source