Results 51 to 60 of about 70,452 (309)
The human C1q globular domain: Structure and recognition of non immune self ligands
Frontiers in Immunology, 2012 C1q, the ligand binding unit of the C1 complex of complement, is a pattern recognition molecule with the unique ability to sense an amazing variety of targets, including a number of altered structures from self, such as apoptotic cells.
Christine eGaboriaud +3 more
doaj +1 more source
Epitope-Specific Anti-C1q Autoantibodies in Systemic Lupus Erythematosus
Frontiers in Immunology, 2022 ObjectiveIn patients with systemic lupus erythematosus (SLE) complement C1q is frequently targeted by autoantibodies (anti-C1q), that correlate best with active renal disease. Anti-C1q bind to largely unknown epitopes on the collagen-like region (CLR) of
Jessica S. Kleer +12 more
doaj +1 more source
Marine Drugs, 2019 C1q-domain-containing (C1qDC) proteins are rapidly emerging as key players in the innate immune response of bivalve mollusks. Growing experimental evidence suggests that these highly abundant secretory proteins are involved in the recognition of microbe ...
Marco Gerdol +2 more
doaj +1 more source
Health Science Reports, 2021 Background C1q is a crucial component of the classical complement pathway. This study is the first to assess the association between disease activity and serum levels of C1q in Chinese Takayasu arteritis (TA) patients.
Si Chen +6 more
doaj +1 more source
C1q as a target molecule to treat human disease: What do mouse studies teach us?
Frontiers in Immunology, 2022 The complement system is a field of growing interest for pharmacological intervention. Complement protein C1q, the pattern recognition molecule at the start of the classical pathway of the complement cascade, is a versatile molecule with additional non ...
Kristina Schulz +3 more
doaj +1 more source
Effective dynamics of double solitons for perturbed mKdV [PDF]
, 2010 We show that an interacting double soliton solution to the perturbed mKdV equation is close in $H^2$ to a double soliton following an effective dynamics obtained as Hamilton's equations for the restriction of the mKdV Hamiltonian to the submanifold of ...
Holmer, Justin +2 more
core +5 more sources
Frontiers in Immunology, 2016 The heterotrimeric globular head (gC1q) domain of human C1q is made up of the C-terminal ends of the three individual chains, ghA, ghB and ghC. The receptor for the gC1q domain is a multi-functional pattern recognition protein, gC1qR. Since understanding
Lina Pednekar +12 more
doaj +1 more source
Clinical significance of serum complement C1q in diagnosis of malignant tumors
陆军军医大学学报, 2023 Objective To investigate the serum level of complement C1q in patients with malignant tumors and its clinical significance in the diagnosis of the tumors. Methods A retrospective analysis was conducted on 468 patients with malignant tumors (including 164
WANG Yunlong, LI Hongsen, WU Lixiang
doaj +1 more source
SERPINB3 delays glomerulonephritis and attenuates the lupus-like disease in lupus murine models by inducing a more tolerogenic immune phenotype [PDF]
, 2018 Objective: To explore the effects of SERPINB3 administration in murine lupus models with a focus on lupus-like nephritis. Methods: 40 NZB/W F1 mice were subdivided into 4 groups and intraperitoneally injected with recombinant SERPINB3 (7.5 \u3bcg/0.1 mL ...
Beggio, M +12 more
core +2 more sources
Mapping of the complement C1q binding site on Trichinella spiralis paramyosin
Parasites & Vectors, 2018 Background Trichinella spiralis is a tissue-dwelling parasite has developed the ability to evade the host immune attack to establish parasitism in a host.
Zixia Wang +5 more
doaj +1 more source