Results 91 to 100 of about 38,034 (262)
DUX4 differentially regulates transcriptomes of human rhabdomyosarcoma and mouse C2C12 cells. [PDF]
PLoS ONE, 2013 Facioscapulohumeral muscular dystrophy (FSHD) is linked to the deletion of the D4Z4 arrays at chromosome 4q35. Recent studies suggested that aberrant expression of double homeobox 4 (DUX4) from the last D4Z4 repeat causes FSHD.
Vishakha Sharma +3 more
doaj +1 more source
Advanced NanoBiomed Research, EarlyView.We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer +5 more
wiley +1 more source
Doxorubicin stimulates catabolism in C2C12 myotubes
The FASEB Journal, 2010 Doxorubicin, a commonly prescribed chemotherapeutic agent, causes skeletal muscle wasting in cancer patients undergoing chemotherapy. Previous studies in mice show that the E3 ubiquitin ligase, MAFbx/atrogin‐1 is upregulated in skeletal muscle following doxorubicin administration, an effect regulated by p38 ...
Laura A. A. Gilliam +4 more
openaire +1 more source
Effect of miR-143-3p on C2C12 myoblast differentiation [PDF]
Bioscience, Biotechnology, and Biochemistry, 2016 AbstractMicroRNAs are a class of 18–22 nucleotide non-coding RNAs that modulate gene expression by associating with the 3′ untranslated regions of mRNAs. A large number of microRNAs are involved in the regulation of myoblast differentiation, many of which remain undiscovered. In this study, we found that miR-143-3p was upregulated during C2C12 myoblast
Jingjing, Du +12 more
openaire +2 more sources
Tead factor function in C2C12 cells.
, 2017 A. Gene expression was quantified by RT-qPCR during C2C12 cell differentiation after transfection with the indicated siRNAs. B. Fluorescence microscopy images after 6 days of C2C12 cell differentiation following transfection of the indicated siRNAs ...
Gabrielle Mengus (803717) +6 more
core +1 more source
Recloning and Characterization of C2C12 Myoblast and Its Clonal Derivatives
, 2021 The C2C12 myoblasts are adult murine muscle stem cells which isolated after injury to induce muscle regeneration. The cells are widely used in pharmaceutical and biological researches to represent skeletal muscle cells.
Septisetyani, Endah Puji +3 more
core +1 more source
Low glucose but not galactose enhances oxidative mitochondrial metabolism in C2C12 myoblasts and myotubes. [PDF]
PLoS ONE, 2013 BACKGROUND: Substituting galactose for glucose in cell culture media has been suggested to enhance mitochondrial metabolism in a variety of cell lines. We studied the effects of carbohydrate availability on growth, differentiation and metabolism of C2C12
Moustafa Elkalaf +2 more
doaj +1 more source
Tead4 genomic occupancy in C2C12 cells.
, 2017 A-B. Localisation of Tead4 occupied sites in non-differentiated and differentiated C2C12 cells relative to genomic annotations (left panels) and the TSS (right panels). C-D.
Gabrielle Mengus (803717) +6 more
core +1 more source
SMRT suppresses Tgf-β receptor signaling-mediated fibrosis in C2C12 cell.
, 2022 (A) The expression of Tgf-β signaling-related genes in both C2C12-WT and C2C12-SKO cells were quantified by qPCR (n = 3 per group). (B) The expression of fibrosis-related genes in both C2C12-WT and C2C12-SKO cells were quantified by qPCR (n = 3 per group)
Hiroaki Shimizu (440570) +8 more
core +1 more source
Protein phosphatase 1 isoforms in differentiating C2C12 myocytes
European Journal of Cell Biology, 1998 In muscle protein phosphatase 1 (PP1) is involved in growth factor signal transduction and metabolic regulations. Three isoforms of the catalytic subunit are found in mammalian cells (PP1alpha, PP1gamma1 and PP1delta), with potentially different functions. We investigated the changes in the PP1 isoforms in differentiating C2C12 myoblasts.
M. TOGNARINI, VILLA, EMMA
openaire +3 more sources