Results 81 to 90 of about 38,034 (262)
BiologyCancer progression in skeletal muscle (SkM) is very rare, and mechanisms remain unclear. This study assessed the potential of SkM (myocyte)-derived EVs (C2C12-EVs) as anti-cancer agents.
Dona Mannaperuma +3 more
doaj +1 more source
Advanced Science, EarlyView.Dynamic decellularized hydrogels are prepared using bovine decellularized small intestine submucosa (SIS) norbornene (dSIS‐NB). Bovine dSIS contained significant amounts of disulfide‐rich fibrillin‐I, enabling ‘self‐clickable’ thiol‐norbornene gelation and spatiotemporal tuning of hydrogel physicochemical properties.
Van Thuy Duong +4 more
wiley +1 more source
Effects of Hoechst 33342 on C2C12 and PC12 cell differentiation [PDF]
FEBS Letters, 2007 Accumulative evidence demonstrates that normal as well as cancer stem cells can be identified as a side population following Hoechst 33342 staining and flow cytometric analysis. This popular method is based on the ability of stem cells to efflux this fluorescent vital dye.
Adamski, Danièle +5 more
openaire +3 more sources
D151N/H155R double mutant rescues tubulation ability in C2C12 cells.
, 2014 BIN N-BAR* WT and its mutants are fused to GFP and transiently transfected in C2C12 myoblasts. Cells are imaged by confocal fluorescence microscopy. Scale bar: 20 µm. Expression of BIN1 N-BAR* WT causes great membrane tubulation in C2C12 cells.
Zheng Shi (586636) +2 more
core +1 more source
Kinetin riboside but not Kinetin is toxic in C2C12 cells.
, 2021 Kinetin but not Kinetin riboside supplement increased significantly A) fusion index and B) MCK activity, in C2C12 cells grown in GM with 15% FCS, in comparison to C2C12 myoblasts supplemented with DMSO only for 7 days. C) An MTT assay showed that Kinetin
Mark Isalan (26971) +1 more
core +1 more source
Myostatin promotes tenogenic differentiation of C2C12 myoblast cells through Smad3
FEBS Open Bio, 2017 Myostatin, a member of the transforming growth factor‐β (TGF‐β) superfamily, is expressed in developing and adult skeletal muscle and negatively regulates skeletal muscle growth. Recently, myostatin has been found to be expressed in tendons and increases
Kazutaka Uemura +7 more
doaj +1 more source
Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy
Advanced Science, EarlyView.Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang +5 more
wiley +1 more source
Effect of mitochondrial fission inhibition on C2C12 differentiation
Data in Brief, 2016 The differentiation of skeletal muscle is commonly examined in cell culture using the C2C12 line of mouse skeletal myoblasts. This process shares many similarities with that which occurs during embryonic development, such as the transient activation of caspases.
Bloemberg, Darin, Quadrilatero, Joe
openaire +3 more sources
Effects of thimerosal on proliferation of C2C12 myoblast cells.
, 2013 C2C12 myoblast cells were treated with thimerosal (125, 250 and 500 nM) for 24, 48 or 72 h. A. C2C12 myoblast cell viability determined by WST-1. B. Cell cycle distribution of C2C12 myoblast cells analyzed by flow cytometry. C. The percentage of cells in
Hua-Zhang Liu (300078) +6 more
core +1 more source
Advanced Science, EarlyView.PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin +11 more
wiley +1 more source