Results 41 to 50 of about 17,249 (148)

Identification of Histone Deacetylase Inhibitor Targeting Type I Interferon and B Cell Abnormalities in Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) is characterized by increased Type I interferon (IFN‐I) and autoantibody production. This study aimed to identify drugs that can inhibit both IFN‐I and autoantibody production. Methods We identified an inhibitor of IFN‐I production from a chemical library.
Takehiro Hirayama, Hachiro Konaka, Yasuhiro Kato, Takayuki Shibahara, Chisato Nishizawa, Kohei Tsujimoto, JeongHoon Park, Eri Itotagawa, Tatsunori Jo, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Wataru Aoki, Ken J Ishii, Hyota Takamatsu, Atsushi Kumanogoh   +16 more
wiley   +1 more source

Voclosporin‐induced gingival enlargement: A case report

Clinical Advances in Periodontics, EarlyView.
Abstract Background Drug‐influenced gingival enlargement (DIGE) is a recognized adverse effect of certain medications, particularly immunosuppressants like cyclosporin and tacrolimus. However, there have been no documented cases of DIGE associated with voclosporin, a newer calcineurin inhibitor used primarily to treat lupus nephritis.
Francesca Racca, Jessica M. Greco, Dimitris N. Tatakis   +2 more
wiley   +1 more source

Etiopathogenetic, Morphological, Diagnostic and Therapeutic Aspects of Acute Glomerulonephritis: Current Status

Архивъ внутренней медицины, 2020
The review provides up-to-date information on the etiological factors and pathogenic mechanisms of development, morphological changes, clinical and laboratory manifestations of acute glomerulonephritis, as well as therapeutic possibilities for its ...
I. T. Murkamilov, I. S. Sabirov, V. V. Fomin, Zh. A. Murkamilova, K. A. Aytbaev   +4 more
doaj   +1 more source

Pathology of C3 Glomerulonephritis

Journal of the Korean Society of Pediatric Nephrology, 2013
사구체에 면역글로불린은 음성이면서 C3 만 침착되는 경우, 다른 원인이 없는 경우 C3GN을 의심하여야 한다. 광학현미경으로는 세포의 증식이 있는 경우와 없는 경우가 있지만, 전자현미경으로는 EDD가 내피세포 밑으로 혹은 메산지움 등에 침착함을 확인하여야 한다. 대체보체경로의 조절이상이 원인임으로 혈청 C3 치를 비롯하여 CFH, CFI, CFB 등을 측정하여야 하며, C3 nephritic factor, anti-factor H 자가항체 등을 조사하는 것이 필요하다. 보체 조절이상을 일으키는 유전자 돌연변이를 조사해 보아야 한다. 예후는 안정적이지만, 치료는 대증적이다.
openaire   +1 more source

Nonimmunoglobulin C3 activating factor in membranoproliferative glomerulonephritis

Kidney International, 1979
Nonimmunoglobulin C3 activating factor in membranoproliferative glomerulonephritis. Material isolated by cryoprecipitation from the serum of a patient with membranoproliferative glomerulonephritis exhibited alternative complement pathway C3-splitting activity associated with a nonimmunoglobulin γ-migrating protein. The cryoprecipitate required factor B
Bartlow, Bruce G., Roberts, Jimmy L., Lewis, Edmund J.   +2 more
openaire   +2 more sources

Randomised, phase 1 evaluation of the safety, tolerability, pharmacokinetics and pharmacodynamics of iptacopan in healthy volunteers

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Overactivation of the alternative pathway (AP) underlies several diseases. Iptacopan is an oral, first‐in‐class, highly potent specific inhibitor of factor B, a key AP protease. Experimental Approach The analysis included data from two phase 1 randomised, volunteer‐blinded, placebo‐controlled studies: Study 1, a single ...
Irina Baltcheva, Guido Junge, Kenneth Kulmatycki, Robert Schmouder, Anna Schubart, Marie‐Anne Valentin   +5 more
wiley   +1 more source

Clinicopathological and prognostic study of IgA-dominant postinfectious glomerulonephritis

BMC Nephrology, 2021
Background The clinicopathological and prognostic features of IgA-dominant postinfectious glomerulonephritis and its difference from the primary IgA nephropathy remains to be investigated.
Ziyuan Huang, Bo Chen, Ying Zhou, Yan Liang, Wenxian Qiu, Yinqiu Lv, Xiaokai Ding, Ji Zhang, Chaosheng Chen   +8 more
doaj   +1 more source

Pediatric Non‐Lupus Full House Nephropathy: Case Report and Review of Literature

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Lupus nephritis is a severe manifestation of systemic lupus erythematosus (SLE) typically characterized by glomerular “full‐house” immunofluorescence. However, non‐lupus nephropathies may occasionally exhibit similar patterns, creating diagnostic uncertainty.
Mohammad Firoz Anjum, Suraj Sah, Inesh Khanal, Sharmila Gainju, Sri Ram K.C.   +4 more
wiley   +1 more source

Cytomegalovirus Infection Mimics Manifestations of Underlying Diseases in Patients With Autoimmune Disorders: A Case Report and Literature Review

Immunity, Inflammation and Disease, Volume 14, Issue 3, March 2026.
Autoimmune disorder patients are vulnerable to cytomegalovirus (CMV) infections, which can present with symptoms that mimic flare‐ups of the underlying disease. We present two cases: a 44‐year‐old woman with systemic lupus erythematosus and a 55‐year‐old man with sarcoidosis, both of whom developed unusual manifestations linked to CMV infection ...
Elaheh Karimi, Zahra Moradi, Somayeh Soroureddin, Ozra Nouri, Zahra Tamartash, Hoda Kavosi   +5 more
wiley   +1 more source

C3-Dominant Infection Related Crescentic Glomerulonephritis.

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia
Infection related glomerulonephritis and more specifically streptococcal glomerulonephritis is a rare disease in adults, and so is C3 glomerulonephritis. It has been recognized that a clinical and morphological overlap between these two entities exists. We present a case of a 59-year-old man with previous treated HIV infection with virological response,
Wilson, Suarez Molina, Andrés Fabián, Salgado Zamora, Jorge Armando, Pulido Saenz, Daniel Humberto, Ducuara Rodríguez, Diana Carolina, Sánchez Suarez, Angie Katherine, González Ortiz, Rafael Enrique, Andrade, Johanna Álvarez, Figueroa, Laura Chacón, Zambrano   +8 more
openaire   +2 more sources