Results 101 to 110 of about 56,153 (264)

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

The tumour microenvironment links complement system dysregulation and hypoxic signalling. [PDF]

, 2018
The complement system is an innate immune pathway typically thought of as part of the first line of defence against "non-self" species. In the context of cancer, complement has been described to have an active role in facilitating cancer-associated ...
Giaccia, Amato J, Graves, Edward E, Kim, Ryan K, Melemenidis, Stavros, Olcina, Monica M   +4 more
core   +1 more source

Analysis of the Recovery of Immune Status in the Patients With Paroxysmal Nocturnal Hemoglobinuria After Treatment With C5 Complement Inhibitor

Journal of Clinical Laboratory Analysis, EarlyView.
We retrospectively evaluated the impact of C5 complement inhibition on immune cell profiles and recovery in 27 PNH patients; both CD4+ and CD8+ T cells exhibited partial recovery, while B cell counts increased but remained below normal levels. In contrast, Treg cells were significantly reduced in PNH patients and showed no notable change post‐treatment.
Hui Liu, Mengting Che, Liyan Li, Honglei Wang, Chaomeng Wang, Junshu Wu, Yingying Chen, Zhaoyun Liu, Lijuan Li, Rong Fu   +9 more
wiley   +1 more source

1-Methyl-4-({5-[(4-methyl­phen­yl)sulfan­yl]pent­yl}sulfan­yl)benzene [PDF]

, 2009
There are two independent mol­ecules in the asymmetric unit of the title compound, C19H24S2. In both mol­ecules, the aliphatic segment of the ligand is in an all-trans conformation: the –S–(CH2)5–S–bridging chain is almost planar (r.m.s.
Brito, Iván, Cárdenas, Alejandro, Albanez, Joselyn, Bolte, Michael, López-Rodríguez, Matías   +4 more
core   +2 more sources

An Open‐Label Phase 1b Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of ANX005 in Patients with Huntington's Disease

Movement Disorders, EarlyView.
Complement activation is implicated in Huntington's disease; ANX005 is a potent inhibitor of component C1q. ANX005 exhibited a generally manageable safety profile with rapid reduction in C1q in the cerebrospinal fluid. Functional ability on composite Unified Huntington's Disease Rating Scale and total functional capacity was maintained, with potential ...
Rajeev Kumar, Pinky Agarwal, Karen Anderson, Daniel Claassen, Marissa Dean, Andrew Duker, Burton Scott, Benjamin Hoehn, Ann Mongan, Ping Lin, Ellen Cahir‐McFarland, Lori Taylor, Glenn Morrison, Ted Yednock, Sanjay Keswani, Henk‐Andre Kroon   +15 more
wiley   +1 more source

Renormalization group aspects of the local composite operator method [PDF]

, 2006
We review the current status of the application of the local composite operator technique to the condensation of dimension two operators in quantum chromodynamics (QCD).
Browne, R. E., Dudal, D., Gracey, J. A., Lemes, V. E. R., Sarandy, M. S., Sobreiro, R. F., Sorella, S. P., Verschelde, H.   +7 more
core   +3 more sources

Current Status of Kidney Xenotransplantation in Basic Research

Organ Medicine, EarlyView.
Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley   +1 more source

Acidosis activates complement system in vitro

Mediators of Inflammation, 1998
We investigated the in vitro effect of different form s of acidosis (pH 7.0) on the formation of anaphylatoxins C3a and C5a. Metabolic acidosis due to addition of hydrochloric acid (10 μ mol/ml blood) or lactic acid (5.5 μ mol/ml) to heparin blood (N=12)
Michael Emeis, Josef Sonntag, Carsten Willam, Evelyn Strauss, Matthias M. Walka, Michael Obladen   +5 more
doaj   +1 more source

Comparison between two ultrasonic methods in their ability to monitor the setting process of cement pastes [PDF]

, 2009
This paper presents the comparison between ultrasonic wave transmission (USWT) method and ultrasonic wave reflection (USWR) method in their ability to monitor the setting process of cement pastes.
Akkaya, Franci Kavčič, Goran Turk, Gregor Trtnik, Grosse, Hewlett, Kamada, Keating, Korhonen, Krauss, Marko Ivan Valič, Rapoport, Reinhardt, Robeyst, Sayers, Schindler, Stepišnik, Sun, Sun, Trtnik, Valič, Voigt, Voigt, Voigt   +23 more
core   +2 more sources

Enabling effective urban green space stewardship through planning: A qualitative comparative analysis in Southwest England

People and Nature, EarlyView.
Abstract Amid increasing urbanisation and biodiversity decline, ‘effective stewardship’ of urban green space (UGS) is a complex but critical nature‐based solution for long‐term environmental, social and economic gain. Combining stewardship and sense‐of‐place frameworks with European nature‐based solutions guidance, we investigate which social and ...
Fay Kahane, Melissa Ralph, Rosalind F. Shaw   +2 more
wiley   +1 more source