Results 121 to 130 of about 26,236 (223)

Time profile for the production of C3a and C5a.

, 2016
(A) The response generated for C3a shows a lag phase that is followed by an accelerated production phase. In 60 minutes, the amount of C3a produced is 108 times greater than that of C5a. (B) Zoom-in of panel (A) to show the time profile of C5a.
Angel Dorado (2586817), Nehemiah Zewde (2586811), Dimitrios Morikis (108586), Ronald D. Gorham Jr. (2586814)   +3 more
core   +1 more source

Impact of systemic diseases on periodontal remodeling: Mechanisms, mediators, and clinical relevance

Periodontology 2000, EarlyView.
Abstract Background Periodontal remodeling is a continuous, adaptive process essential for maintaining the structural and functional integrity of periodontal tissues. While external factors such as bacterial biofilm, excessive forces, and poor oral hygiene are recognized triggers of periodontal pathologies, they do not fully explain their persistent ...
Michael Wolf, Ulrike Schulze‐Späte, Thomas Van Dyke, Stefan Wolfart, Thomas Dietrich, Alberto Ortiz, Zhuojun Wu, Joachim Jankowski   +7 more
wiley   +1 more source

Complement-derived anaphylatoxin C3a regulates in vitro differentiation and migration of neural progenitor cells

, 2009
Anaphylatoxin C3a is a third complement component (C3)-derived peptide, the multiple functions of which range from stimulation of inflammation to neuroprotection. In a previous study, we have shown that signaling through C3a receptor positively regulates
Ståhlberg, Anders,, Shinjyo, Noriko,, Pekna, Marcela,, Dragunow, Mike, Pekny, Milos,   +4 more
core   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Exogenous recombinant complement proteins C3a and C5a regulate osteogenic differentiation of P-PDLSCs: a process associated with the Wnt/beta-catenin axis

Immunobiology
Objective: Concentrated growth factor (CGF) is rich in growth factors and complement proteins like C3a and C5a, showing promise for enhancing tissue regeneration.
Lingyan Peng, Yong Zhang, Xiaohui Yin, Fei Li, Jing Qiao   +4 more
doaj   +1 more source

Breakthrough Hemolysis in Paroxysmal Nocturnal Hemoglobinuria: Mechanistic Insights and Management Strategies

Transfusion, EarlyView.
Abstract Background Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic stem cell disorder caused by somatic mutations in the PIGA gene, resulting in loss of glycosylphosphatidylinositol (GPI)‐anchored proteins, including the complement regulatory proteins, CD55 and CD59.
Ganesh Raman, Meghana Vivek, Rida Hasan, Siobán Keel, Laura Connelly‐Smith   +4 more
wiley   +1 more source

Associations between serum complement component 3a and sC5b⁃9 levels with the prognosis of sepsis patients

Zhongguo linchuang yanjiu
"Objective To investigate the associations of serum complement component 3a（C3a）and soluble terminalcomplement complex C5b⁃9（sC5b⁃9）levels with the severity of sepsis and 28⁃day clinical prognosis among patients，and to provide new biomarker references ...
SU Yixing，BAO Lei，YU Jun'an，GU Zhijian
doaj   +1 more source

C3a targets the Hippo-YAP signaling pathway to promote Müller cells glial–mesenchymal transition in a high-glucose in vitro model

European Journal of Medical Research
Background Diabetic retinopathy (DR) is the most common microvascular complication of diabetes, severely affecting the health and quality of life of individuals with diabetes.
Shuang Liu, Long Suo, Hongliang Chen, Qiankun Wang, Dongyuan Mao, Yuanyuan Cai, Bing Qin   +6 more
doaj   +1 more source

The complement C3a/C3aR pathway is associated with treatment resistance to gemcitabine-based neoadjuvant therapy in pancreatic cancer

Computational and Structural Biotechnology Journal
Gemcitabine is a standard first-line drug for pancreatic cancer chemotherapy. Nevertheless, gemcitabine resistance is common and significantly limits its therapeutic efficacy, impeding advancements in pancreatic cancer treatment. In this study, through a
Saimeng Shi, Longyun Ye, Kaizhou Jin, Xianjun Yu, Duancheng Guo, Weiding Wu   +5 more
doaj   +1 more source

Hydration reactions in suspensions of C3A + C3S + CaSO4.2aq. in water

, 1974
In suspensions of C3A in water, C3AH6 formation is counteracted by the addition of CaSO4.2aq.or of large additions of C3S but promoted by small additions of C3S.
Stevels, JM, Stevels, J.M., Corstanje, W.A., Stein, H.N., Stein, HN, Corstanje, WA Willem   +5 more
core   +1 more source