Complement C3c as a Biomarker in Heart Failure [PDF]
Mediators of Inflammation, 2013 Introduction. Experimental data indicates an important role of the innate immune system in cardiac remodeling and heart failure (HF). Complement is a central effector pathway of the innate immune system. Animals lacking parts of the complement system are
A. Frey +5 more
doaj +6 more sources
C3c intrathecal synthesis evaluation in patients with multiple sclerosis Evaluación de la síntesis intratecal de C3c en pacientes con esclerosis múltiple [PDF]
Arquivos de Neuro-Psiquiatria, 2007 INTRODUCTION: Multiple sclerosis (MS) is a chronic, inflammatory and progressive disease of the central nervous system in which local inflammatory injuries of the brain white matter appears, being the most outstanding feature the myeline loss ...
Bárbara Padilla-Docal +6 more
doaj +9 more sources
Complement C3c and C4c as predictors of death in heart failure [PDF]
IJC Metabolic & Endocrine, 2015 AbstractBackgroundActivation of the immune system is one of the several pathways suggested as involved in Heart Failure (HF). The complement system is a key component of innate immunity. We hypothesized that complement proteins C3 and C4 can be an important predictor of death in patients with this condition.Methods380 patients admitted with acute HF ...
Sandra Martins +2 more
exaly +5 more sources
C3C: A New Static Content-Based Three-Level Web Cache [PDF]
IEEE Access, 2019 One way of improving the performance of a search engine is increasing the hit ratio of the search engine cache. A common and widely used approach for increasing the hit ratio is a combination of the result cache, the posting list cache, and the ...
Thanh Trinh +2 more
doaj +3 more sources
On the Y-chromosome haplogroup C3c classification [PDF]
Journal of Human Genetics, 2012 As there are ambiguities in classification of the Y-chromosome haplogroup C3c, relatively frequent in populations of Northern Asia, we analyzed all three haplogroup-defining markers M48, M77 and M86 in C3-M217-individuals from Siberia, Eastern Asia and Eastern Europe.
B A Malyarchuk +2 more
exaly +3 more sources
Expression of melanoma differentiation-associated gene 5 in the epidermis and cutaneous deposition of complement C3 and immunoglobulins in patients with dermatomyositis. [PDF]
PLoS ONEObjectivesDermatomyositis (DM) is an autoimmune disease characterized by interface dermatitis, but the immunopathological features underlying cutaneous inflammation remain incompletely understood.
Yoshiaki Zaizen +6 more
doaj +2 more sources
Complement and autoantibody levels under anifrolumab therapy in SLE: implications for clinical practice [PDF]
Frontiers in ImmunologyIntroductionAnifrolumab (ANI), a type I interferon receptor antagonist, has demonstrated clinical efficacy in systemic lupus erythematosus (SLE). However, its effects on serological markers commonly used to assess disease activity in clinical practice ...
Jan-Gerd Rademacher +3 more
doaj +2 more sources
Selective Complement Inhibition in Anti-p200 Pemphigoid: Immune Infiltrate Profiles and Therapeutic Implications Compared to Bullous Pemphigoid [PDF]
BiomoleculesAnti-p200 pemphigoid is an autoimmune blistering disease (AIBD) caused by autoantibodies against laminin β4 and/or γ1, and clinically resembles bullous pemphigoid (BP) as well as the inflammatory variant of epidermolysis bullosa acquisita (EBA).
Shirin Emtenani +5 more
doaj +2 more sources
Obesity as a Determinant of Periodontal Therapy Outcomes: Insights on Oxidative and Endoplasmic Reticulum Stress Pathways [PDF]
International Dental JournalPurpose: To assess the impact of non-surgical periodontal treatment (NSPT) on the oxidative and endoplasmic reticulum (ER) stress response of leukocytes, and to examine whether obesity modulates the biological response to periodontal treatment.
Jonathan Hermenejildo +12 more
doaj +2 more sources
Complement levels and their diagnostic utility in neonatal sepsis [PDF]
BMC PediatricsBackground This study evaluated the diagnostic value of complement levels in neonatal sepsis and their roles in disease progression. Methods This diagnostic accuracy study, conducted in Guangdong Province, China (January 2021-February 2022), involved 41 ...
Fuqiang Diao +7 more
doaj +2 more sources