Results 21 to 30 of about 4,947 (220)

Complement in Renal Disease as a Potential Contributor to Arterial Hypertension

Kidney & Blood Pressure Research, 2021
Objective: Complement deposition is prevalent in kidney biopsies of patients with arterial hypertension and hypertensive nephropathy, but an association of hypertension and complement deposition or involvement of complement in the pathogenesis of ...
Lisa-Maren Fischer, Laura A. Fichte, Maike Büttner-Herold, Fulvia Ferrazzi, Kerstin Amann, Kerstin Benz, Christoph Daniel   +6 more
doaj   +3 more sources

Functional assessment of mouse complement pathway activities. and quantification of C3b/C3c/iC3b in an experimental model of mouse renal ischaemia/reperfusion injury

, 2015
The complement system is an essential component of our innate immunity, both for the protection against infections and for proper handling of dying cells. However, the complement system can also contribute to tissue injury and inflammatory responses.
Seelen, Marc A., Daha, Mohamed R., van Werkhoven, Maaike B., Klar-Mohamad, N., Klar-Mohamad, Ngaisah, Rutjes, Helma, Daha, M.R., Schilders, G., Kotimaa, Juha P.; id_orcid, Schilders, Geurt, van Kooten, Cees, Werkhoven, M.B. van, Kotimaa, Juha P., Rutjes, H., Groningen, J. van, Seelen, M.A., Kooten, C. van, O'Flynn, J., O'Flynn, Joseph, van Groningen, Jan, Kotimaa, J.P.   +20 more
core   +3 more sources

How can immunohistochemistry improve the diagnosis of pemphigus foliaceus?

Human Pathology: Case Reports, 2018
Purpose: Pemphigus foliaceus (PF) is a rare, autoimmune blistering disorder characterized by the production of autoantibodies against desmoglein 1. The mainstay for diagnosis is the demonstration of immune complex deposition by direct immunofluorescence (
Denise Miyamoto, Celina Maruta, Claudia Santi, Pablo Zoroquiain, Ana Beatriz Dias, Ligia Fukumori, Alexandre Perigo, Valeria Aoki, Miguel Burnier, Jr   +8 more
doaj   +2 more sources

Structure of Compstatin in Complex with Complement Component C3c Reveals a New Mechanism of Complement Inhibition

, 2007
Undesired complement activation is a major cause of tissue injury in various pathological conditions and contributes to several immune complex diseases. Compstatin, a 13-residue peptide, is an effective inhibitor of the activation of complement component
Els F. Halff, Halff, E.F., Lambris, J.D., Bert J.C. Janssen, Janssen, B.J.C., Gros, P., Dep Scheikunde, Piet Gros, Kristal- en structuurchemie, John D. Lambris   +9 more
core   +2 more sources

Complement, but Not Platelets, Plays a Pivotal Role in the Outcome of Mucormycosis In Vivo

Journal of Fungi, 2023
Background: Mucormycetes, a heterogeneous group of fungi, induce a life-threatening disease called mucormycosis. Immune deficiencies represent a major risk factor; hence, we wanted to illuminate the role of complement and platelets in the defense against
Verena Harpf, Günter Rambach, Nadia Parth, Magdalena Neurauter, Verena Fleischer, Michaela Lackner, Cornelia Lass-Flörl, Reinhard Würzner, Cornelia Speth   +8 more
doaj   +2 more sources

Load capacity for walls built with C3C block system –flooding loads

, 2021
Floods are the natural disaster that causes the most deaths and economic damage in the world. Sweden has been relatively spared from casualties in connection with floods, but the material damage is significant.
Blomberg, Johan, Sörgårn, Alfred
core   +3 more sources

KOMPLEMEN SERUM C3C DAN LIMFOSIT T-CD4+ DARAH

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY, 2016
The incidence of HIV and AIDS infection continues to increase despite various treatments have been applied, thus the mortality rate remains high. The examination of CD4+ T lymphocytes number to determine the immune status and the monitoring of therapy has some limitations in facilities and personnel examination as well as expensive costs.
Parwati, I Komang, Retnowati, Endang, Agustina Tambunan, Betty   +2 more
openaire   +2 more sources

Redefined complement C3c structures have significant increase in the plasma of ovarian cancer patients. [PDF]

J Chin Med Assoc
Chen DH, Chang YW, Chien CH, Torng PL, Tsay YG.   +4 more
europepmc   +2 more sources

Development of a Novel Enzyme-Linked Immunosorbent Assay Targeting a Neo-Epitope Generated by Cathepsin-Mediated Turnover of Type III Collagen and Its Application in Chronic Obstructive Pulmonary Disease. [PDF]

PLoS ONE, 2017
A high level of extracellular matrix (ECM) turnover characterizes several lung diseases with fibrotic features. Type III collagen is one of the most abundant collagens in lung parenchyma, and cathepsins play a role in lung pathology, being responsible ...
Daniel Guldager Kring Rasmussen, Jannie Marie Bülow Sand, Morten Asser Karsdal, Federica Genovese   +3 more
doaj   +1 more source

Complement activation in Hidradenitis suppurativa: Covert low-grade inflammation or innocent bystander?

Frontiers in Immunology, 2022
Hidradenitis suppurativa (HS) is a chronic auto-inflammatory skin disease with a complex and multifactorial pathogenesis involving both the innate and adaptive immune system.
K. R. van Straalen, K. Dudink, P. Aarts, H. H. van der Zee, T. P. P. van den Bosch, J. Giang, E. P. Prens, E. P. Prens, J. Damman   +8 more
doaj   +1 more source