New insights for C5a and C5a receptors in sepsis [PDF]
Frontiers in Immunology, 2012 The complement system plays a central role in inflammation and immunity. Among the complement activation products, C5a is one of the most potent inflammatory peptides with a broad spectrum of functions.
Hongwei eGao, Chunguang eYan
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Stiffness-tuned and ROS-sensitive hydrogel incorporating complement C5a receptor antagonist modulates antibacterial activity of macrophages for periodontitis treatment [PDF]
Bioactive Materials, 2023 Periodontitis is admittedly a microbe-driven intractable infectious disease, in which Porphyromonas gingivalis (Pg) plays a keystone role. Pg can selectively impair the antimicrobial responses of periodontal resident macrophages including their ...
Ziqi Gan +10 more
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Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody [PDF]
Journal of Innate Immunity, 2023 Introduction: The complement system anaphylatoxin C5a is a critical player in inflammation. By binding to complement C5a receptor 1 (C5aR1/CD88), C5a regulates many cellular functions, mainly as a potent pro-inflammatory inducer.
Leon Cyranka +6 more
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Ras-Related Protein Rab5a Regulates Complement C5a Receptor Trafficking, Chemotaxis, and Chemokine Secretion in Human Macrophages [PDF]
Journal of Innate Immunity, 2023 Complement activation and Rab GTPase trafficking are commonly observed in inflammatory responses. Recruitment of innate immune cells to sites of infection or injury and secretion of inflammatory chemokines are promoted by complement component 5a (C5a ...
Kai-Chen Wu +5 more
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Complement C5a Receptor Signaling Alters Stress Responsiveness and Modulates Microglia Following Chronic Stress Exposure [PDF]
Biological Psychiatry Global Open ScienceBackground: Accumulating evidence underscores the pivotal role of heightened inflammation in the pathophysiology of stress-related diseases, but the underlying mechanisms remain elusive.
Hsiao-Jou Cortina Chen +7 more
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Complement C3a and C5a receptor blockade modulates regulatory T cell conversion in head and neck cancer [PDF]
Journal for ImmunoTherapy of Cancer, 2021 Background Resistance to therapy is a major problem in treating head and neck squamous cell carcinomas (HNSCC). Complement system inhibition has been shown to reduce tumor growth, metastasis, and therapeutic resistance in other tumor models, but has yet ...
Emily K Kleczko +2 more
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The Controversial C5a Receptor C5aR2: Its Role in Health and Disease [PDF]
Journal of Immunology Research, 2017 After the discovery of the C5a receptor C5aR1, C5aR2 is the second receptor found to bind C5a and its des-arginine form. As a heptahelical G protein-coupled receptor but devoid of the intracellular Gα signal, C5aR2 is special and confusing. Ramifications
Ting Zhang, Malgorzata A. Garstka, Ke Li
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Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism [PDF]
Communications Biology, 2020 Dumitru et al. probe the ligand-binding mechanism and activation of the human G protein-coupled C5a receptor (C5aR) and discover a cooperativity between the two orthosteric binding sites.
Andra C. Dumitru +6 more
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Restoring the glioblastoma tumor microenvironment by targeting C5a with the antagonist W54011 [PDF]
Scientific ReportsGlioblastoma (GBM) poses a serious challenge due to its aggressive nature and poor prognosis. Tumor mesenchymal stem-like cells (tMSLCs) secrete complement component 5a (C5a), altering the tumor microenvironment (TME) and promoting tumor progression ...
Yoojung Oh +9 more
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7α-Hydroxycholesterol induces monocyte/macrophage cell expression of interleukin-8 via C5a receptor. [PDF]
PLoS ONE, 2017 We investigated effects of 7-oxygenated cholesterol derivatives present in atherosclerotic lesions, 7α-hydroxycholesterol (7αOHChol), 7β-hydroxycholesterol (7βOHChol), and 7-ketocholesterol (7K), on IL-8 expression.
Hyok-Rae Cho +6 more
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