Results 91 to 100 of about 2,358,049 (278)

Experimental Malaria in Pregnancy Induces Neurocognitive Injury in Uninfected Offspring via a C5a-C5a Receptor Dependent Pathway

PLoS Pathogens, 2015
The in utero environment profoundly impacts childhood neurodevelopment and behaviour. A substantial proportion of pregnancies in Africa are at risk of malaria in pregnancy (MIP) however the impact of in utero exposure to MIP on fetal neurodevelopment is ...
Chloe R. McDonald, L. Cahill, Keith T. Ho, Jimmy Yang, Hani Kim, Karlee L. Silver, P. Ward, H. Mount, W. Liles, J. Sled, K. Kain   +10 more
semanticscholar   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Benefit of Apabetalone on Plasma Proteins in Renal Disease. [PDF]

, 2018
Introduction:Apabetalone, a small molecule inhibitor, targets epigenetic readers termed BET proteins that contribute to gene dysregulation in human disorders. Apabetalone has in vitro and in vivo anti-inflammatory and antiatherosclerotic properties.
Gilham, Dean, Halliday, Christopher, Jahagirdar, Ravi, Johansson, Jan O, Kalantar-Zadeh, Kamyar, Kulikowski, Ewelina, Robson, Richard, Stotz, Stephanie C, Sweeney, Michael, Tsujikawa, Laura M, Wasiak, Sylwia, Wong, Norman C   +11 more
core   +2 more sources

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Basophils activation of patients with chronic spontaneous urticaria in response to C5a despite failure to respond to IgE-mediated stimuli

Frontiers in Immunology, 2022
Urticaria is characterized by the occurrence of wheals and flares in response to vasoactive mediators, such as histamine. Various studies have suggested the involvement of basophils in the pathogenesis of chronic spontaneous urticaria (CSU).
Daiki Matsubara, Yuhki Yanase, Kaori Ishii, Shunsuke Takahagi, Akio Tanaka, Koichiro Ozawa, Michihiro Hide, Michihiro Hide   +7 more
doaj   +1 more source

What is new in the management of rapidly progressive glomerulonephritis? [PDF]

, 2015
Rapidly progressive glomerulonephritis (RPGN) results from severe crescentic damage to glomeruli and leads to irreversible kidney failure if not diagnosed and managed in a timely fashion.
Greenhall, GHB, Salama, AD
core   +1 more source

Dinuclear Rhodium(I)–N‐Heterocyclic Carbene Complexes as Alkyne Hydropyridonation Catalysts

European Journal of Inorganic Chemistry, EarlyView.
Catalyst Improvement by NHC tuning: A series of new RhI–NHC dinuclear complexes has been revealed as efficient alkyne hydropyridonation catalysts. 333053IMes complex displays the highest reactivity of the series, suggesting that a moderate steric demand combined with balanced σ‐donation facilitates precatalyst activation and substrate exchange.
Belinda Español‐Sánchez, Mert Olgun Karataş, Andrea Di Giuseppe, Ulugbek Togaev, Vincenzo Passarelli, Luis A. Oro, Jesús J. Pérez‐Torrente, Ricardo Castarlenas   +7 more
wiley   +1 more source

Assessment of the immunomodulatory properties of the probiotic strain Lactobacillus paracasei K5 in vitro and in vivo [PDF]

, 2020
Lactobacillus paracasei K5 is a lactic acid bacteria (LAB) strain that has been isolated from dairy products. Previous studies have established its probiotic potential in a series of in vitro tests, including molecular characterization, safety profiling,
Alexopoulos, Athanasios, Bezirtzoglou, Eugenia, Botaitis, Sotiris, Chondrou, Pelagia, Galanis, Alex, Karapetsas, Athanasios, Kiousi, Despoina Eugenia, Plessas, Stavros, Vasileiadis, Stavros, Ypsilantis, Petros   +9 more
core   +2 more sources

Prenatal betamethasone–postnatal N‐methyl‐D‐aspartic acid model of spasms: Update on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira, Antonia Schonwald, Chian‐Ru Chern, Kamya Shah, Jana Velíšková, Libor Velíšek   +5 more
wiley   +1 more source

CD177-mediated nanoparticle targeting of human and mouse neutrophils. [PDF]

PLoS ONE, 2018
Neutrophils are the most abundant white blood cells, with a vital role in innate immune defense against bacterial and fungal pathogens. Although mostly associated with pathological processes directly related to immune defense, they can also play a ...
Heini M Miettinen, Jeannie M Gripentrog, Connie I Lord, Jon O Nagy   +3 more
doaj   +1 more source