Meningococcal Serogroup Y Meningitis Reveals Inborn Factor B Deficiency
European Journal of Immunology, Volume 56, Issue 2, February 2026.We report a novel case of complete complement Factor B deficiency revealed by invasive meningococcal disease. Using combined functional and genetic analyses, we demonstrate that loss of Factor B abolishes alternative pathway activity despite detectable protein levels. These findings provide a mechanistic framework relevant to complement diagnostics and
Camille Bougeard +9 more
wiley +1 more source
BiomoleculesIdiopathic pulmonary fibrosis (IPF) is characterized by excessive extracellular matrix (ECM) deposition driven by aberrant fibroblast-to-myofibroblast transition (FMT).
Tingting Ren +5 more
doaj +1 more source
A Greater Increase in Complement C5a Receptor 1 Level at Onset and a Smaller Decrease in Immunoglobulin G Level after Recovery in Severer Coronavirus Disease 2019 Patients: A New Analysis of Existing Data with a New Two-Tailed t-Test. [PDF]
Biology (Basel), 2023 Ishida T +7 more
europepmc +1 more source
Bufalin Inhibits Cytokine Storm by Regulating TLR4/TLR3 Signaling Pathway
Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.ABSTRACT Background Bufalin is one main component of the dried venom from Bufo gargarizans Cantor, which has anti‐tumor, cardiotonic, anti‐inflammatory and other physiological activities. However, in recent years, researchers have mainly paid attention to its anti‐tumor effect and neglected its anti‐inflammatory effect.
Xixi Liu +11 more
wiley +1 more source
CellsThe conjunctiva has immune-responsive properties to protect the eye from infections. Its innate immune system reacts against external pathogens, such as fungi. The complement factor C5a is an important contributor to the initial immune response.
Loreena Rech +5 more
doaj +1 more source
Blood Transcriptome Analysis of Septic Patients Reveals a Long Non-Coding Alu-RNA in the Complement C5a Receptor 1 Gene. [PDF]
Noncoding RNA, 2022 Emblem Å +7 more
europepmc +1 more source
Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets
MedComm, Volume 7, Issue 2, February 2026.This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen +5 more
wiley +1 more source
Mathematical Methods in the Applied Sciences, Volume 49, Issue 3, Page 1914-1942, February 2026.ABSTRACT Examining the extent to which measurements of rotation matrices are close to each other is challenging due measurement noise. To overcome this, data is typically smoothed, and the Riemannian and Euclidean metrics are applied. However, if rotation matrices are not directly measured and are instead formed by eigenvectors of measured symmetric ...
P. D. Ledger +2 more
wiley +1 more source
Vascular Endothelial Cells Produce Coagulation Factors That Control Their Growth via Joint Protease-Activated Receptor and C5a Receptor 1 (CD88) Signaling. [PDF]
Am J Pathol, 2022 Cao D +8 more
europepmc +1 more source
Complement C5a and C5a receptor 1 mediates glomerular damage in focal segmental glomerulosclerosis
Clinical ImmunologyClinical data and animal models have provided compelling evidence supporting the pathogenic role of complement activation in the progression of focal segmental glomerulosclerosis (FSGS). However, the mechanisms underlying complement-induced podocyte injury and parietal epithelial cell (PEC) activation are not well understood.We evaluated glomerular ...
Xiao-Jie, Gong +7 more
openaire +2 more sources