C5a Receptor Deficiency Alters Energy Utilization and Fat Storage [PDF]
PLoS ONE, 2013 Objective: To investigate the impact of whole body C5a receptor (C5aR) deficiency on energy metabolism and fat storage. Design: Male wildtype (WT) and C5aR knockout (C5aRKO) mice were fed a low fat (CHOW) or a high fat high sucrose diet-induced obesity ...
Cianflone, Katherine +10 more
core +8 more sources
The role of complement C5a receptor in DPSC odontoblastic differentiation and in vivo reparative dentin formation. [PDF]
Int J Oral Sci, 2022 Therapeutic dentin regeneration remains difficult to achieve, and a majority of the attention has been given to anabolic strategies to promote dentinogenesis directly, whereas, the available literature is insufficient to understand the role of ...
Irfan M +6 more
europepmc +2 more sources
The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets. [PDF]
Nat Commun, 2021 Platelets contribute to the regulation of tissue neovascularization, although the specific factors underlying this function are unknown. Here, we identified the complement anaphylatoxin C5a-mediated activation of C5a receptor 1 (C5aR1) on platelets as a ...
Nording H +26 more
europepmc +2 more sources
Inhibition of complement C5a receptor protects lung cells and tissues against lipopolysaccharide-induced injury via blocking pyroptosis. [PDF]
Aging (Albany NY), 2021 Acute lung injury (ALI) is the injury of alveolar epithelial cells and capillary endothelial cells caused by various factors. Complement system and pyroptosis have been proved to be involved in ALI, and inhibition of C5a/C5a receptor (C5aR) could ...
Wang R, Wang Y, Hu L, Lu Z, Wang X.
europepmc +2 more sources
Targeting Complement C5a Receptor 1 for the Treatment of Immunosuppression in Sepsis. [PDF]
Mol Ther, 2021 Sommerfeld O +11 more
europepmc +2 more sources
Preclinical Pharmacokinetics of Complement C5a Receptor Antagonists PMX53 and PMX205 in Mice. [PDF]
ACS Omega, 2020 The cyclic hexapeptides PMX53 and PMX205 are potent noncompetitive inhibitors of complement C5a receptor 1 (C5aR1). They are widely utilized to study the role of C5aR1 in mouse models, including central nervous system (CNS) disease, and are dosed through
Kumar V +5 more
europepmc +2 more sources
Adjunctive Treatment With Avacopan, an Oral C5a Receptor Inhibitor, in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. [PDF]
ACR Open Rheumatol, 2020 This study aimed to evaluate the safety of avacopan, an orally administered C5a receptor inhibitor, for the treatment of antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis in addition to standard‐of‐care (SOC) treatment with glucocorticoids
Merkel PA +10 more
europepmc +2 more sources
Knockout mouse models reveal the contributions of G protein subunits to complement C5a receptor-mediated chemotaxis. [PDF]
J Biol Chem, 2020 G protein–coupled receptor signaling is required for the navigation of immune cells along chemoattractant gradients. However, chemoattractant receptors may couple to more than one type of heterotrimeric G protein, each of which consists of a Gα, Gβ, and ...
van den Bos E +8 more
europepmc +2 more sources
The complement system and its role in the treatment of ANCA-associated vasculitis
Journal of Education, Health and Sport, 2022 Objective: This study aimed to evaluate the role of the complement system in a therapy of the ANCA- associated vasculitis. Methods and materials: A literature search was conducted in the PubMed MEADLINE database of medical publications using the
Natalia Rybak +5 more
doaj +1 more source
N-Acetylcysteine Attenuates Cisplatin-Induced Acute Kidney Injury by Inhibiting the C5a Receptor. [PDF]
Biomed Res Int, 2019 N-acetylcysteine has been widely used as a nutritional supplement and drug in humans for its antioxidant properties. The complement activation fragment C5a is a strong proinflammatory molecule that mediates cell adhesion, chemotaxis, and the complex ...
Huang S +7 more
europepmc +2 more sources