Results 111 to 120 of about 7,153 (219)
GALDIERO is CO-FIRST AUTHOR. Phagocytes as Corrupted Policemen in Cancer-Related Inflammation [PDF]
, 2015 Inflammation is a key component of the tumor microenvironment. Tumor-associated macrophages (TAMs) and tumor-associated neutrophils (TANs) are prototypic inflammatory cells in cancer-related inflammation.
Bonavita, Eduardo +3 more
core +1 more source
Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets
MedComm, Volume 7, Issue 2, February 2026.This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen +5 more
wiley +1 more source
Advanced Science, Volume 13, Issue 4, 19 January 2026.This study examines major depressive disorder with atypical features and psychotic symptoms through a multi‐omics precision medicine approach. By integrating clinical assessments, WBC scRNA‐seq, plasma proteomics, and brain organoid models, it uncovers immune dysregulation, synaptic protein alterations, and stress‐sensitive neuronal changes.
Insook Ahn +5 more
wiley +1 more source
Role of the C5a/C5aR1 axis in bone cells
, 2023 The complement system is an important part of the innate immune system, which is activated by endogenous or exogenous pathogens. The main functions of the complement system are the direct destruction of pathogens and cellular components, opsonization and initiation of phagocytosis, and the induction of an inflammatory response.
openaire +2 more sources
Frontiers in Cellular and Infection Microbiology, 2019 Respiratory viral infections can directly lead to kidney damage such as IgA nephropathy (IgAN), partly due to mucosal immune system dysfunction. Although the activated C5a-C5aR1 axis results in increased Th1 and Th17 frequencies but reduced Treg ...
Xinyue Hu +8 more
doaj +1 more source
Analysis of lactoferin gene polymophism and its association to milk quality and mammary gland health in Holstein-Friesian cows [PDF]
, 2013 Lactoferrin (LTF) is a glycoprotein, a member of transferrin gene family which plays an important role in immune mechanisms in the mammary glands of cows.
Kanjac Slobodanka +6 more
core +1 more source
Single‐Cell Insights Into Macrophage Subtypes in Pulmonary Infections
Advanced Science, Volume 13, Issue 3, 14 January 2026.This review highlights the dynamic plasticity of macrophages during pulmonary infections and proposes an integrative framework defining six functional subtypes: Inflam‐Ms, Hub‐Ms, Reg‐Ms, Prolif‐Ms, Memory‐Ms, and Senesc‐Ms. Single‐cell omics delineate their distinct roles in homeostasis and infection, refining our understanding of macrophage ...
Zhaoheng Lin +3 more
wiley +1 more source
Molecular Neurodegeneration, 2017 Background Pharmacologic inhibition of C5aR1, a receptor for the complement activation proinflammatory fragment, C5a, suppressed pathology and cognitive deficits in Alzheimer's disease (AD) mouse models.
Michael X. Hernandez +11 more
doaj +1 more source
Complement C5a Induces Pro-inflammatory Microvesicle Shedding in Severely Injured Patients
Frontiers in Immunology, 2020 Initially underestimated as platelet dust, extracellular vesicles are continuously gaining interest in the field of inflammation. Various studies addressing inflammatory diseases have shown that microvesicles (MVs) originating from different cell types ...
Ebru Karasu +10 more
doaj +1 more source
Glutamate Receptors and Synaptic Plasticity in Health and Disease: A Personal Journey
Hippocampus, Volume 36, Issue 1, January 2026.ABSTRACT I describe my progress in understanding synaptic plasticity in the hippocampus. Over the decades my lab has focused on the roles of glutamate receptors (AMPARs, NMDARs, mGluRs and KARs) and associated signaling molecules in LTP and LTD. Most of our studies have been conducted in area CA1 (Schaffer collateral—commissural pathway) with some ...
Graham L. Collingridge
wiley +1 more source