Results 191 to 200 of about 7,153 (219)

C5aR2 receptor: The genomic twin of the flamboyant C5aR1

Journal of Cellular Biochemistry, 2022
AbstractThe complement fragment C5a is one of the most potent proinflammatory glycoproteins liberated by the activation of the biochemical cascade of the complement system. C5a is established to interact with a set of genomically related transmembrane receptors, like C5aR1 (CD88, C5aR) and C5aR2 (GPR77, C5L2) with comparable affinity.
Aurosikha Das, Pulkit K. Gupta, Soumendra Rana   +2 more
openaire   +2 more sources

Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins

Nature Chemical Biology, 2023
The complement receptors C3aR and C5aR1, whose signaling is selectively activated by anaphylatoxins C3a and C5a, are important regulators of both innate and adaptive immune responses. Dysregulations of C3aR and C5aR1 signaling lead to multiple inflammatory disorders, including sepsis, asthma and acute respiratory distress syndrome.
Yue Wang, Weiyi Liu, Youwei Xu, Xinheng He, Qingning Yuan, Ping Luo, Wenjia Fan, Jingpeng Zhu, Xinyue Zhang, Xi Cheng, Yi Jiang, H. E. Xu, Y. Zhuang   +12 more
semanticscholar   +3 more sources

C5aR1

2018
C5aR1 is the lynchpin of communication between complement activation and the cellular immune response. It acts as a G-protein coupled receptor to attract and activate leucocytes in response to C5a. The genetic locus for C5aR1 consists of two exons separated by a large intron, a structure it shares with the other anaphylatoxin receptors.
Coulthard, Liam G., Hawksworth, Owen A., Woodruff, Trent M.   +2 more
openaire   +2 more sources

Targeting C5aR1 Reveals Protective Macrophage Maturation States in Intestinal Injury

bioRxiv
Abstract Inflammatory intestinal injury, which may occur following cytotoxic cancer treatments such as radiotherapy, compromises homeostasis when intestinal stem cells undergo apoptosis and regeneration programmes are not effectively engaged.
Heather Clark, Ian J. Chai, S. Melemenidis, Dhanya K. Nambiar, Kim K. Ryan, Yanyan Jiang, Kerriann M. Casey, Iryna Zherka, Dominika Majorova, Trent M. Woodruff, Edward G. Graves, Q. Le, Simon JA. Buczacki, A. Giaccia, M. Olcina   +14 more
semanticscholar   +2 more sources

C5a-C5aR1 axis controls mitochondrial fission to promote podocyte injury in lupus nephritis.

Molecular Therapy
Podocytes are essential to maintaining the integrity of the glomerular filtration barrier, yet they are frequently affected in lupus nephritis (LN).
Baokui Ye, Binfeng Chen, Chaohuan Guo, Ningjing Xiong, Yuefang Huang, Mengyuan Li, Yimei Lai, Jin Li, Mianjing Zhou, Shuang Wang, Shuyi Wang, N. Yang, Hui Zhang   +12 more
semanticscholar   +1 more source

Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation

Science Immunology, 2021
Mitochondrial C5aR1 signaling is required for proinflammatory macrophage activity during crystal-induced sterile inflammation.
Nathalie Niyonzima, Jubayer Rahman, Natalia Kunz, Erin E. West, Tilo Freiwald, Jigar V. Desai, Nicolas S. Merle, Alexandre Gidon, Bjørnar Sporsheim, Michail S. Lionakis, Kristin Evensen, Beate Lindberg, Karolina Skagen, Mona Skjelland, Parul Singh, Markus Haug, Marieta M. Ruseva, Martin Kolev, Jack Bibby, Olivia Marshall, Brett O’Brien, Nigel Deeks, Behdad Afzali, Richard J. Clark, Trent M. Woodruff, Milton Pryor, Zhi-Hong Yang, Alan T. Remaley, Tom E. Mollnes, Stephen M. Hewitt, Bingyu Yan, Majid Kazemian, Máté G. Kiss, Christoph J. Binder, Bente Halvorsen, Terje Espevik, Claudia Kemper   +36 more
openaire   +2 more sources

Dysregulations of C1QA, C1QB, C1QC and C5AR1 as candidate biomarkers of vascular dementia

npj Aging
Vascular dementia (VaD) is the second most common cause of dementia. Few bioinformatic analysis has been done to explore its biomarkers. This study aimed to excavate potential biomarkers for VaD using bioinformatic analysis and validate them at both ...
Yawen Xu, Hailing Zhang, Xuehao Jiao, Yanbo Zhang, Ge Yin, Cui Wang, Zengkan Du, Meng Liang, Xin Gao, Zhengsheng Gu, Yan Jiang, Bingying Du, Xiaoying Bi   +12 more
semanticscholar   +1 more source

Interaction of Phosphorylated C5aR1 With β‐Arrestin1: A Comparative Structural Modeling Study

Proteins: Structure, Function, and Bioinformatics
The complement system is an essential element of the immune response, significantly contributing to the body's defense against pathogens by augmenting inflammation, opsonizing pathogens, and promoting cell lysis.
Pulkit Kr. Gupta, Aditi Singh, Soumendra Rana   +2 more
semanticscholar   +1 more source

Double Deletion of C5aR1 and C5aR2 during Streptococcal Pneumonia

The Journal of Immunology, 2020
Abstract The complement system is essential for the clearance of encapsulated bacteria such as Streptococcus pneumoniae (Spn), recognized as a major pathogen of pneumonia. Yet, it is not entirely clear whether C5 and its activation product C5a have beneficial or detrimental effects on the outcome of Spn infection.
Sarah Walachowski, Markus Dudek, Leonid Eshkind, Vanessa Tansi, Joseph P Mizgerd, Markus Bosmann   +5 more
openaire   +1 more source

TMIC-28. Glioblastoma-derived ribosomal protein S19 exacerbates cerebral edema through C5AR1 in tumor-associated macrophages

Neuro-Oncology
Cerebral edema in glioblastoma (GBM) leads to increased intracranial pressure, neurological dysfunctions, and fatal brain herniation. Our previous single-cell transcriptomic analysis of GBM patient samples identified a specific tumor-to-tumor ...
Chan-Chuan Liu, Cheng-Lin Wu, Chih-Yang Wang, J. Chuang, K. Chang   +4 more
semanticscholar   +1 more source