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The complement system, traditionally considered a peripheral component of the body's innate immune response, comprises approximately 50 membrane-bound and soluble proteins that form a rapid and potent enzymatic cascade. This cascade facilitates the opsonisation, phagocytosis, and osmotic lysis of invading pathogens and detrimental host tissue.
openaire +2 more sources

Icariin ameliorates LPS-induced acute lung injury in mice via complement C5a-C5aR1 and TLR4 signaling pathways.

International Immunopharmacology
Acute lung injury (ALI) is an acute respiratory-related progressive disorder, which lacks specific pharmacotherapy. Icariin (ICA) has been shown to be effective in treating ALI.
Jing Guo +4 more
semanticscholar +1 more source

Abstract 5216: RPS19-C5AR1 axis in tumor-associated macrophages drives glioblastoma progression: Insights from single-cell transcriptomics

Cancer Research
Glioblastoma (GBM) is a prevalent and lethal disease with limited treatment options. Tumor-associated macrophages (TAMs), which comprise up to 30% of the GBM mass, play a pivotal role in shaping the TME by supporting tumor growth and establishing an ...
Chan-Chuan Liu +6 more
semanticscholar +1 more source

Pericyte and Macrophage C5aR1 Mediate Renal Fibrosis