Results 171 to 180 of about 6,618 (201)

Neutrophils as key drivers of pulmonary fibrosis: unveiling mechanisms and therapeutic implications. [PDF]

Front Immunol
Liang X, Li Y, Tang Z, Luo Y, Liu Y.
europepmc   +1 more source

The free fatty acid 2 receptor regulates the activation potency of C5a and the sensitivity to the antagonist avacopan

Khan Z, Levin NK, Dahlgren C, Sundqvist M, Khan F, Forsman H, Björkman L.   +6 more
europepmc   +1 more source

Metachronous bilateral renal cancer with immune checkpoint blockade-mediated eradication of bone metastasis: case report. [PDF]

Front Oncol
Metodiev D, Borisov T, Da Costa PA, Redissi A, Cremer I, Petrova M, Vano YA, Roumenina LT, Ferdinandov D.   +8 more
europepmc   +1 more source

Complement role in kidney disease: a comprehensive review and therapeutic innovations. [PDF]

BMC Nephrol
Cortez Ferreira B, Matos Silva G, Venda J, Afonso N, Leal R, Cerqueira S, Galvão A, Sá H.   +7 more
europepmc   +1 more source

Molecular mechanism of naturally-encoded signaling-bias at the complement anaphylatoxin receptors

Tiwari D, Sawada K, Dalal A, Mishra S, Li XX, Dent JC, Kim K, Yadav MK, Roy N, Ganguly M, Banerjee N, Stepniewski TM, Ahn D, Yamaguchi K, Oshima HS, Hashimoto K, Fung JN, Lerskiatiphanich T, Cui CS, Lee JD, Selent J, Inoue A, Clark R, Chung KY, Banerjee R, Sano FK, Woodruff TM, Nureki O, Shukla AK.   +28 more
europepmc   +1 more source

<i>Adu</i>CPI2 alleviates MSU-induced acute gouty arthritis in mice by inhibiting cathepsin S and the C5a-C5aR1 axis. [PDF]

Front Pharmacol
Liu S, Situ Y, Deng L, Liang M, He H, Shao Z, Peng L.   +6 more
europepmc   +1 more source

Inhibition of C5AR1 impairs osteoclast mobilization and prevents bone loss

Molecular Therapy, 2023
Age-related and chemotherapy-induced bone loss depends on cellular senescence and the cell secretory phenotype. However, the factors secreted in the senescent microenvironment that contribute to bone loss remain elusive. Here, we report a central role for the inflammatory alternative complement system in skeletal bone loss.
Francesc Pujol Ventura
exaly   +3 more sources

Intracellular complement C5a/C5aR1 stabilizes β-catenin to promote colorectal tumorigenesis

Cell Reports, 2022
Complement is operative in not only the extracellular but also the intracellular milieu. However, little is known about the role of complement activation inside tumor cells. Here, we report that intracellular C5 is cleaved by cathepsin D (CTSD) to produce C5a in lysosomes and endosomes of colonic cancer cells.
Peipei Ding, Xiaochao Wang, Weiguo Hu
exaly   +3 more sources

Mechanism of activation and biased signaling in complement receptor C5aR1

Cell Research, 2023
AbstractThe complement system plays an important role in the innate immune response to invading pathogens. The complement fragment C5a is one of its important effector components and exerts diverse physiological functions through activation of the C5a receptor 1 (C5aR1) and associated downstream G protein and β-arrestin signaling pathways.
Yuying Feng, Chang Zhao, heli wang
exaly   +3 more sources