Results 161 to 170 of about 5,552 (193)

Double Deletion of C5aR1 and C5aR2 during Streptococcal Pneumonia

The Journal of Immunology, 2020
Abstract The complement system is essential for the clearance of encapsulated bacteria such as Streptococcus pneumoniae (Spn), recognized as a major pathogen of pneumonia. Yet, it is not entirely clear whether C5 and its activation product C5a have beneficial or detrimental effects on the outcome of Spn infection.
Sarah Walachowski, Markus Dudek, Leonid Eshkind, Vanessa Tansi, Joseph P Mizgerd, Markus Bosmann   +5 more
openaire   +1 more source

Interaction of Phosphorylated C5aR1 With β‐Arrestin1: A Comparative Structural Modeling Study

Proteins: Structure, Function, and Bioinformatics
The complement system is an essential element of the immune response, significantly contributing to the body's defense against pathogens by augmenting inflammation, opsonizing pathogens, and promoting cell lysis.
Pulkit Kr. Gupta, Aditi Singh, Soumendra Rana   +2 more
semanticscholar   +1 more source

The C5AR1/TNFSF13B axis alleviates osteoarthritis by activating the PI3K/Akt/GSK3β/Nrf2/HO-1 pathway to inhibit ferroptosis

Experimental Cell Research
Chondrocyte ferroptosis induces the occurrence of osteoarthritis (OA). As a key gene of OA, C5a receptor 1 (C5AR1) is related to ferroptosis. Here, we investigated whether C5AR1 interferes with chondrocyte ferroptosis during OA occurrence.
Lin Liu
exaly   +2 more sources

Astragaloside IV alleviates LPS-induced acute lung injury by regulating receptor C5aR1 and macrophage pyroptosis.

International Immunopharmacology
Astragaloside IV (AS-IV), derived from Astragalus membranaceus, exhibits significant anti-inflammatory properties in a variety of diseases. However, the specific anti-inflammatory mechanism of AS-IV depends on the different organs and doses.
Zonghui Xu, Man Li, Lin Liu, Shujing Wu, Ruoan Wei, Mpofu Uphakeme Inobubele Sitholumusa, Xiao-Ping Zhao, JUN-QIU Liu, Guo-Yin Kai   +8 more
semanticscholar   +1 more source

Chemical synthesis methods for the C5aR1 inhibitor DF2593A

2020
Detailed chemical synthesis methodology for C5aR1 antagonist DF2593A.
openaire   +1 more source

TMIC-28. Glioblastoma-derived ribosomal protein S19 exacerbates cerebral edema through C5AR1 in tumor-associated macrophages

Neuro-Oncology
Cerebral edema in glioblastoma (GBM) leads to increased intracranial pressure, neurological dysfunctions, and fatal brain herniation. Our previous single-cell transcriptomic analysis of GBM patient samples identified a specific tumor-to-tumor ...
Chan-Chuan Liu, Cheng-Lin Wu, Chih-Yang Wang, J. Chuang, K. Chang   +4 more
semanticscholar   +1 more source

The C5a/C5aR1 axis promotes migration of tolerogenic dendritic cells to lymph nodes, impairing the anticancer immune response.

Cancer immunology research
The precise mechanisms by which the complement system contributes to the establishment of an immunosuppressive tumor microenvironment (TME) and promotes tumor progression remain unclear.
Yaiza Senent, A. Remírez, David Repáraz, Diana Llópiz, Daiana P. Celias, C. Sainz, Rodrigo Entrialgo-Cadierno, Lucía Suárez, A. Rouzaut, D. Alignani, B. Tavira, John D Lambris, Trent M. Woodruff, Carlos E. de Andrea, B. Ruffell, Pablo Sarobe, D. Ajona, R. Pio   +17 more
semanticscholar   +1 more source

C5AR1-induced TLR1/2 pathway activation drives proliferation and metastasis in anaplastic thyroid cancer

Molecular Carcinogenesis
This study aimed to elucidate the role and mechanisms of Complement C5a receptor 1 (C5AR1) in driving the malignant progression of anaplastic thyroid carcinoma (ATC). C5AR1 expression was assessed in ATC tissues and cell lines.
Yueyao Sun, Chenxu Zhao
exaly   +2 more sources

Tumor-derived C4BPA promotes macrophage M2-like polarization through C5a -C5aR1-STAT3 axis and drives gastric cancer progression.

International Immunopharmacology
BACKGROUND C4b-binding protein α (C4BPA) is a soluble complement regulator reported to be altered in several malignancies, but its role in gastric cancer (GC) biology and tumor-immune crosstalk remains unclear.
Zhechuan Zhang, Yuchen Xie, Keqi Yu, Zhijun Chen, Li-Hua Lu, Min-Li Yang, Jie Hu, Jin-Jun Guo   +7 more
semanticscholar   +1 more source

Synergistic function of C5aR1 and C5aR2 complement receptors in defending against bacterial pneumonia 4441

Journal of Immunology
Streptococcus pneumoniae (Spn) is the leading cause of pneumonia-associated mortality in adults. Complement activation is critical for encapsulated Spn clearance but also augments ARDS pathogenesis. C5a binding to its two receptors, C5aR1 and C5aR2,
Sarah Walachowski, A. Jayaraman, M. Dudek, Joshua D. Campbell, J. Mizgerd, M. Bosmann   +5 more
semanticscholar   +1 more source