Results 151 to 160 of about 5,552 (193)

Conformational variants of the ternary complex of C5a, C5aR1, and G-protein

Journal of Biomolecular Structure and Dynamics
The complement component fragment 5a (C5a) binds and activates two complement receptors like C5aR1 and C5aR2, which play a significant role in orchestrating the proinflammatory function of C5a in tissues through the recruitment of heterotrimeric G ...
Soumendra Rana, Pulkit Kr Gupta, Aditi Singh   +2 more
exaly   +4 more sources

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PTX3 Deficiency Aggravates Periodontitis by the Complement C5a-C5aR1 Axis

Journal of Dental Research
Dysregulation of the complement system plays a critical role in periodontitis progression. In addition to the harmful effects of biofilm, aberrant expression of complement regulatory proteins is also a potential cause of periodontitis. Pentraxin 3 (PTX3)
W. Dong, D. Guo, C. Yang, Q. Xu, J. Wang
semanticscholar   +3 more sources

Inhibition of C5AR1 impairs osteoclast mobilization and prevents bone loss

Molecular Therapy, 2023
Age-related and chemotherapy-induced bone loss depends on cellular senescence and the cell secretory phenotype. However, the factors secreted in the senescent microenvironment that contribute to bone loss remain elusive. Here, we report a central role for the inflammatory alternative complement system in skeletal bone loss.
Francesc Ventura, Andres Méndez-Lucas, Cristina Sánchez-de-Diego   +2 more
exaly   +3 more sources

C5aR2 receptor: The genomic twin of the flamboyant C5aR1

Journal of Cellular Biochemistry, 2022
AbstractThe complement fragment C5a is one of the most potent proinflammatory glycoproteins liberated by the activation of the biochemical cascade of the complement system. C5a is established to interact with a set of genomically related transmembrane receptors, like C5aR1 (CD88, C5aR) and C5aR2 (GPR77, C5L2) with comparable affinity.
Aurosikha Das, Pulkit K. Gupta, Soumendra Rana   +2 more
openaire   +2 more sources

C5aR1

2018
C5aR1 is the lynchpin of communication between complement activation and the cellular immune response. It acts as a G-protein coupled receptor to attract and activate leucocytes in response to C5a. The genetic locus for C5aR1 consists of two exons separated by a large intron, a structure it shares with the other anaphylatoxin receptors.
Owen A Hawksworth, Trent M. Woodruff, Liam G Coulthard   +2 more
exaly   +5 more sources

C5aR1 signaling promotes region- and age-dependent synaptic pruning in models of Alzheimer's disease

Alzheimer's and Dementia
Synaptic loss is a hallmark of Alzheimer's disease (AD) that correlates with cognitive decline in AD patients. Complement‐mediated synaptic pruning has been associated with this excessive loss of synapses in AD.
Angela Gomez-Arboledas, Nicole D Schartz, Marcelo A Wood   +2 more
exaly   +2 more sources

C5a-C5aR1 axis controls mitochondrial fission to promote podocyte injury in lupus nephritis

Molecular Therapy
Podocytes are essential to maintaining the integrity of the glomerular filtration barrier, yet they are frequently affected in lupus nephritis (LN).
Binfeng Chen, Yimei Lai, Chaohuan Guo
exaly   +2 more sources

C5aR1+ microglia exacerbate neuroinflammation and cerebral edema in acute brain injury.

Neuron
Microglia rapidly respond to acute brain injury and contribute to neuroinflammation that drives cerebral edema, a major cause of mortality and disability in stroke and traumatic brain injury (TBI).
Jin-Peng Zhou, Shuo-Yao Ma, Da-Yun Feng, Yang Tian, Leiyang Li, Hao Guo, Ying-wu Shi, Wen-Xing Cui, Jing-Yu Dong, Sijia Hao, Chengxuan Guo, Meng Xu, Liying Han, H. Bai, Dan He, Xiao Cui, Lian Chen, Xun Wu, Fei Gao, Qing Hu, Zi-Wen Zhang, Kai Wang, Gaoyang Zhou, Tian Feng, Dong-Zhi Xue, Qian Lin, Liang Wang, Li Gao, Li-Jun Heng, Tianzhi Zhao, Tao Luo, Boxue Tian, Xingye Zhang, Wei Guo, Zhihong Li, Hai-Xiao Liu, Shun-Nan Ge, Qiang Liu, Yan Qu   +38 more
semanticscholar   +1 more source

The impact of the complement receptors C3aR1 and C5aR1 on the progression of melanoma

The Journal of Immunology, 2023
Abstract Melanoma is an aggressive skin cancer that develops from the malignant transformation of pigment-producing skin cells, melanocytes. The incidence of cutaneous melanoma is remarkably high, with an estimated number of new cases in the United States in 2022 close to 100,000 patients.
Selin Oncul, Min Soon Cho, Hani Lee, Wendolyn E Carlos-Alcalde, Shailbala Singh, Cassian Yee, Vahid Afshar-Kharghan   +6 more
openaire   +1 more source

Targeting the C5-C5aR1 Axis: A promising therapeutic strategy for Alzheimer's disease and amyotrophic lateral sclerosis by Unlocking Neuroprotection.

Biochemical Pharmacology
C5aR1 is a G protein-coupled receptor (GPCR) which is involved in exacerbating neurodegenerative diseases, including Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS).
Tong-Qi Ge, Pu Wang, Pei-Pei Guan
semanticscholar   +1 more source