Results 141 to 150 of about 4,346 (168)

The impact of the complement receptors C3aR1 and C5aR1 on the progression of melanoma

The Journal of Immunology, 2023
Abstract Melanoma is an aggressive skin cancer that develops from the malignant transformation of pigment-producing skin cells, melanocytes. The incidence of cutaneous melanoma is remarkably high, with an estimated number of new cases in the United States in 2022 close to 100,000 patients.
Selin Oncul, Min Soon Cho, Hani Lee, Wendolyn E Carlos-Alcalde, Shailbala Singh, Cassian Yee, Vahid Afshar-Kharghan   +6 more
openaire   +1 more source

Double Deletion of C5aR1 and C5aR2 during Streptococcal Pneumonia

The Journal of Immunology, 2020
Abstract The complement system is essential for the clearance of encapsulated bacteria such as Streptococcus pneumoniae (Spn), recognized as a major pathogen of pneumonia. Yet, it is not entirely clear whether C5 and its activation product C5a have beneficial or detrimental effects on the outcome of Spn infection.
Sarah Walachowski, Markus Dudek, Leonid Eshkind, Vanessa Tansi, Joseph P Mizgerd, Markus Bosmann   +5 more
openaire   +1 more source

Chemical synthesis methods for the C5aR1 inhibitor DF2593A

2020
Detailed chemical synthesis methodology for C5aR1 antagonist DF2593A.
openaire   +1 more source

PTX3 Deficiency Aggravates Periodontitis by the Complement C5a-C5aR1 Axis

Journal of Dental Research
Dysregulation of the complement system plays a critical role in periodontitis progression. In addition to the harmful effects of biofilm, aberrant expression of complement regulatory proteins is also a potential cause of periodontitis. Pentraxin 3 (PTX3) is involved in complement activation and regulation, seeking a balance between amplifying ...
W. Dong, D. Guo, C. Yang, Q. Xu, J. Wang
openaire   +2 more sources

Elucidating the role of neuronal C5aR1

The complement system, traditionally considered a peripheral component of the body's innate immune response, comprises approximately 50 membrane-bound and soluble proteins that form a rapid and potent enzymatic cascade. This cascade facilitates the opsonisation, phagocytosis, and osmotic lysis of invading pathogens and detrimental host tissue.
openaire   +2 more sources

C5aR1+ microglia exacerbate neuroinflammation and cerebral edema in acute brain injury

Neuron
Microglia rapidly respond to acute brain injury and contribute to neuroinflammation that drives cerebral edema, a major cause of mortality and disability in stroke and traumatic brain injury (TBI). However, microglial heterogeneity complicates precise therapeutic targeting because specific disease-associated subtypes remain poorly characterized.
Jinpeng, Zhou, Shuoyao, Ma, Dayun, Feng, Yang, Tian, Leiyang, Li, Hao, Guo, Yingwu, Shi, Wenxing, Cui, Jingyu, Dong, Sijia, Hao, Chengxuan, Guo, Meng, Xu, Liying, Han, Hao, Bai, Dan, He, Xiao, Cui, Lian, Chen, Xun, Wu, Fei, Gao, Qing, Hu, Ziwen, Zhang, Kai, Wang, Gaoyang, Zhou, Tian, Feng, Dongzhi, Xue, Qian, Lin, Liang, Wang, Li, Gao, Lijun, Heng, Tianzhi, Zhao, Tao, Luo, Bo, Tian, Xingye, Zhang, Wei, Guo, Zhihong, Li, Haixiao, Liu, Shunnan, Ge, Qiang, Liu, Yan, Qu   +38 more
openaire   +2 more sources

Microglial C5aR1 defines a pathogenic inflammatory axis driving cerebral edema

Neuron
Zhou et al.1 identify a C5aR1+ microglial subtype that amplifies neuroinflammation after traumatic brain injury and intracerebral hemorrhage. The mechanism reveals microglial-astrocyte-neutrophil crosstalk driving cerebral edema, highlighting C5aR1 as a therapeutic target and raising new questions about complement-glial interactions.
Amnah, Al-Sayyar, Rejane, Rua
openaire   +2 more sources

Pericyte and Macrophage C5aR1 Mediate Renal Fibrosis

Journal of the American Society of Nephrology, 2020
Ranjit K. Sahu, Sandhya Xavier, Daniel Chauss, Ronald P. Taylor, Majid Kazemian, Behdad Afzali, Didier Portilla   +6 more
openaire   +1 more source

Intracellular complement C5a/C5aR1 stabilizes β-catenin to promote colorectal tumorigenesis

Cell Reports, 2022
Weiguo Hu, Peipei Ding, Xinyue Lv
exaly  

C5aR1 Mediates the Progression of Inflammatory Responses in the Brain of Rats in the Early Stage after Ischemia and Reperfusion

ACS Chemical Neuroscience, 2021
Cai Ping Wang, Yijun Deng, Yunwei Shi
exaly