Results 181 to 190 of about 6,618 (201)
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Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins
Nature Chemical Biology, 2023The complement receptors C3aR and C5aR1, whose signaling is selectively activated by anaphylatoxins C3a and C5a, are important regulators of both innate and adaptive immune responses. Dysregulations of C3aR and C5aR1 signaling lead to multiple inflammatory disorders, including sepsis, asthma and acute respiratory distress syndrome.
Youwei Xu, Xin-heng He, Xi Cheng
exaly +3 more sources
C5aR2 receptor: The genomic twin of the flamboyant C5aR1
Journal of Cellular Biochemistry, 2022AbstractThe complement fragment C5a is one of the most potent proinflammatory glycoproteins liberated by the activation of the biochemical cascade of the complement system. C5a is established to interact with a set of genomically related transmembrane receptors, like C5aR1 (CD88, C5aR) and C5aR2 (GPR77, C5L2) with comparable affinity.
Aurosikha Das +2 more
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Science Immunology, 2021
Mitochondrial C5aR1 signaling is required for proinflammatory macrophage activity during crystal-induced sterile inflammation.
Nathalie Niyonzima +2 more
exaly +3 more sources
Mitochondrial C5aR1 signaling is required for proinflammatory macrophage activity during crystal-induced sterile inflammation.
Nathalie Niyonzima +2 more
exaly +3 more sources
2018
C5aR1 is the lynchpin of communication between complement activation and the cellular immune response. It acts as a G-protein coupled receptor to attract and activate leucocytes in response to C5a. The genetic locus for C5aR1 consists of two exons separated by a large intron, a structure it shares with the other anaphylatoxin receptors.
Coulthard, Liam G. +2 more
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C5aR1 is the lynchpin of communication between complement activation and the cellular immune response. It acts as a G-protein coupled receptor to attract and activate leucocytes in response to C5a. The genetic locus for C5aR1 consists of two exons separated by a large intron, a structure it shares with the other anaphylatoxin receptors.
Coulthard, Liam G. +2 more
openaire +2 more sources
Double Deletion of C5aR1 and C5aR2 during Streptococcal Pneumonia
The Journal of Immunology, 2020Abstract The complement system is essential for the clearance of encapsulated bacteria such as Streptococcus pneumoniae (Spn), recognized as a major pathogen of pneumonia. Yet, it is not entirely clear whether C5 and its activation product C5a have beneficial or detrimental effects on the outcome of Spn infection.
Sarah Walachowski +5 more
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PTX3 Deficiency Aggravates Periodontitis by the Complement C5a-C5aR1 Axis
Journal of Dental ResearchDysregulation of the complement system plays a critical role in periodontitis progression. In addition to the harmful effects of biofilm, aberrant expression of complement regulatory proteins is also a potential cause of periodontitis. Pentraxin 3 (PTX3) is involved in complement activation and regulation, seeking a balance between amplifying ...
W. Dong, D. Guo, C. Yang, Q. Xu, J. Wang
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Chemical synthesis methods for the C5aR1 inhibitor DF2593A
2020Detailed chemical synthesis methodology for C5aR1 antagonist DF2593A.
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Structural analysis of the human C5a-C5aR1 complex using cryo-electron microscopy
Journal of Structural BiologyThe complement system is a complex network of proteins that plays a crucial role in the innate immune response. One important component of this system is the C5a-C5aR1 complex, which is critical in the recruitment and activation of immune cells. In-depth investigation of the activation mechanism as well as biased signaling of the C5a-C5aR1 system will ...
Tingting, Yang +15 more
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Pericyte and Macrophage C5aR1 Mediate Renal Fibrosis
Journal of the American Society of Nephrology, 2020Ranjit K. Sahu +6 more
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