Results 201 to 210 of about 7,153 (219)

Chemical synthesis methods for the C5aR1 inhibitor DF2593A

2020
Detailed chemical synthesis methodology for C5aR1 antagonist DF2593A.
openaire   +1 more source

Synergistic function of C5aR1 and C5aR2 complement receptors in defending against bacterial pneumonia 4441

Journal of Immunology
Streptococcus pneumoniae (Spn) is the leading cause of pneumonia-associated mortality in adults. Complement activation is critical for encapsulated Spn clearance but also augments ARDS pathogenesis. C5a binding to its two receptors, C5aR1 and C5aR2,
Sarah Walachowski, A. Jayaraman, M. Dudek, Joshua D. Campbell, J. Mizgerd, Markus Bosmann   +5 more
semanticscholar   +1 more source

Schwann cell C5aR1 co-opts inflammasome NLRP1 to sustain pain in a mouse model of endometriosis

Nature Communications
Over 60% of women with endometriosis experience abdominopelvic pain and broader pain manifestations, including chronic back pain, fibromyalgia, chronic fatigue, vulvodynia, and migraine.
Mustafa Titiz, L. Landini, Daniel Souza Monteiro de Araújo, Matilde Marini, V. Seravalli, Martina Chieca, Pasquale Pensieri, Marco Montini, G. De Siena, Benedetta Pasquini, S. Vannuccini, L. Iannone, Thiago M. Cunha, Giulia Brancolini, Elisa Bellantoni, Irene Scuffi, Alessandra Mastricci, Martina Tesi, M. Di Tommaso, F. Petraglia, Pierangelo Geppetti, R. Nassini, Francesco De Logu   +22 more
semanticscholar   +1 more source

The C5a/C5aR1 axis promotes migration of tolerogenic dendritic cells to lymph nodes, impairing the anticancer immune response.

Cancer immunology research
The precise mechanisms by which the complement system contributes to the establishment of an immunosuppressive tumor microenvironment (TME) and promotes tumor progression remain unclear.
Yaiza Senent, A. Remírez, David Repáraz, Diana Llopiz, Daiana P. Celias, C. Sainz, Rodrigo Entrialgo-Cadierno, Lucía Suárez, A. Rouzaut, D. Alignani, Beatriz Tavira, John D Lambris, Trent M. Woodruff, CE de Andrea, B. Ruffell, Pablo Sarobe, D. Ajona, Ruben Pio   +17 more
semanticscholar   +1 more source

Abstract 5216: RPS19-C5AR1 axis in tumor-associated macrophages drives glioblastoma progression: Insights from single-cell transcriptomics

Cancer Research
Glioblastoma (GBM) is a prevalent and lethal disease with limited treatment options. Tumor-associated macrophages (TAMs), which comprise up to 30% of the GBM mass, play a pivotal role in shaping the TME by supporting tumor growth and establishing an ...
Chan-Chuan Liu, G. Anuraga, Cheng-Lin Wu, J. Chuang, Chih-Yang Wang, Pin-Yuan Chen, K. Chang   +6 more
semanticscholar   +1 more source

Structural analysis of the human C5a-C5aR1 complex using cryo-electron microscopy

Journal of Structural Biology
The complement system is a complex network of proteins that plays a crucial role in the innate immune response. One important component of this system is the C5a-C5aR1 complex, which is critical in the recruitment and activation of immune cells. In-depth investigation of the activation mechanism as well as biased signaling of the C5a-C5aR1 system will ...
Tingting, Yang, Jian, Li, Xinyu, Cheng, Qiuyuan, Lu, Zara, Farooq, Ying, Fu, Sijia, Lv, Weiwei, Nan, Boming, Yu, Jingjing, Duan, Yuting, Zhang, Yang, Fu, Haihai, Jiang, Peter J, McCormick, Yanyan, Li, Jin, Zhang   +15 more
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C5AR1‐induced TLR1/2 pathway activation drives proliferation and metastasis in anaplastic thyroid cancer

Molecular Carcinogenesis
This study aimed to elucidate the role and mechanisms of Complement C5a receptor 1 (C5AR1) in driving the malignant progression of anaplastic thyroid carcinoma (ATC). C5AR1 expression was assessed in ATC tissues and cell lines.
Bo Liu, Yueyao Sun, Tongyao Geng, Hongya Wang, Zhenyu Wu, Lei Xu, Miao Zhang, Xu-Peng Niu, Chenxu Zhao, Jin Shang, Fangjian Shang   +10 more
semanticscholar   +1 more source

Pericyte and Macrophage C5aR1 Mediate Renal Fibrosis

Journal of the American Society of Nephrology, 2020
Ranjit K. Sahu, Sandhya Xavier, Daniel Chauss, Ronald P. Taylor, Majid Kazemian, Behdad Afzali, Didier Portilla   +6 more
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Understanding the role of C5a/C5aR1-mediated complement activation pathway in tumor progression and therapy resistance.

Science China Life Sciences
Lemei Zheng, Jianxia Wei, Mengna Li, Changning Xue, Qingqing Wei, Zubing Wu, Xiaolong Li, Ting Zeng, Huizhen Xin, Wei Xiong, Hongyu Deng, Ming Zhou   +11 more
semanticscholar   +1 more source

Astragaloside IV alleviates LPS-induced acute lung injury by regulating receptor C5aR1 and macrophage pyroptosis.

International Immunopharmacology
Zonghui Xu, Man Li, Lin Liu, Shujing Wu, Ruo-An Wei, Mpofu Uphakeme Inobubele Sitholumusa, Xiao-Ping Zhao, Junqiu Liu, Guoyin Kai   +8 more
semanticscholar   +1 more source