Results 161 to 170 of about 14,543 (225)

Amyotrophic lateral sclerosis and chronic inflammatory demyelinating polyneuropathy coexistence in a patient with a C9orf72 variant: case report. [PDF]

Front Dement
File C, Price AM, Ahmad R, Shanina E, Sun RL.   +4 more
europepmc   +1 more source

Targeting the integrated stress response or Ataxin-2 alleviates neurodegeneration in PolyGR models of C9orf72 associated frontotemporal dementia and amyotrophic lateral sclerosis. [PDF]

Acta Neuropathol Commun
Harper NS, Sharpe JL, Speranza J, Gulia R, Chen JX, Allen SP, Atwal MS, Pickering-Brown S, Livesey MR, Bennett CL, Prokop A, La Spada AR, West RJH.   +12 more
europepmc   +1 more source

PU.1 restores microglial dysfunction caused by C9ORF72 repeat expansions in neural organoids. [PDF]

Brain
Ljubikj T, Mars MZ, van der Geest AT, Jakobs CE, Bessler N, Donega V, van den Oetelaar XPRM, de Wit M, Pasterkamp RJ.   +8 more
europepmc   +1 more source

MicroRNA profiling in post-mortem spinal cord of C9ORF72-related ALS patients reveals molecular pathways involved in motor neuron degeneration. [PDF]

Front Neurosci
Farinazzo G, Giagnorio E, Marcuzzo M, Cattaneo M, Malacarne C, Cavalcante P, Bonanno S, Maderna E, Pensato V, Gellera C, Marucci G, Mazzetti S, Salvi E, Lauria G, Marcuzzo S.   +14 more
europepmc   +1 more source

Poly-GR promotes ferroptosis-associated vulnerability in C9orf72-ALS. [PDF]

Cell Biosci
Lin CY, Hsieh WC, Wang SM.
europepmc   +1 more source

Blocking RAN translation without altering repeat RNAs rescues <i>C9ORF72</i>-related ALS and FTD phenotypes. [PDF]

Science
Jiang X, Schaeffer L, Patni D, Russo T, Lee CZ, Aguilar C, Marques C, Jansen-West K, Hruska-Plochan M, Ray-Soni A, Lim SM, Held A, Yue M, Castellanos Otero P, Aryal S, Beaussant HDAM, Basu H, Takakuwa H, Daughrity LM, Ramesh N, Da Costa P, A A Quadros AR, Nolan M, Reyes CJF, Wheeler H, Moran LC, Griesman G, Wymann B, Trombetta BA, Lopez-De-Silanes ES, Canori M, Krishnan G, Vieira Souza Da Silva Y, Eriani G, Albers MW, Arnold SE, Song Y, Jain A, Chiu IM, Zhang YJ, Gao FB, Wainger BJ, Polymenidou M, Petrucelli L, Martin F, Lagier-Tourenne C.   +45 more
europepmc   +1 more source

Aberrant CDK4/6-driven cell-cycle reentry drives neuronal loss and defines a therapeutic target in C9orf72 ALS/FTD. [PDF]

iScience
Lian L, Robinson H, Daniels N, Prieto GA, Poplawski GHD, Lopez-Gonzalez R.   +5 more
europepmc   +1 more source

Integrative Multi-Omics Mendelian Randomization Highlights Causal Autophagy-Related Genes for Amyotrophic Lateral Sclerosis. [PDF]

Brain Behav
Jiang Z, Ren YL, Gu XJ, Su WM, Duan QQ, Yin KF, Cao B, Li JY, Yan B, Chen YP.   +9 more
europepmc   +1 more source

Somatic mosaicism in ALS and FTD identifies focal mutations associated with widespread degeneration. [PDF]

Nat Genet
Zhou Z, Kim J, Huang AY, Nolan M, Park J, Doan R, Shin T, Miller MB, Bae M, Zhao B, Kim J, Chhouk B, Morillo K, Yeh RC, Kenny C, Neil JE, Lee CZ, Ohkubo T, Ravits J, Ansorge O, Ostrow LW, Lagier-Tourenne C, Lee EA, Walsh CA.   +23 more
europepmc   +1 more source

Increased neuronal activity restores circadian function in Drosophila models of C9orf72-ALS/FTD. [PDF]

iScience
Inami S, Jenny BP, Akpoghiran O, Gallagher SI, Strich AK, Tonoki A, Trotti D, Haeusler AR, Koh K.   +8 more
europepmc   +1 more source