Hyperoside protects against poly-GR-mediated neurodegeneration via regulation of mitochondrial fission and oxidative stress in C9orf72-associated ALS. [PDF]
Chin MedHsieh WC +4 more
europepmc +1 more source
Disrupted astrocyte-neuron metabolic coupling in amyotrophic lateral sclerosis. [PDF]
Front Cell Dev BiolHeffernan ÁB +5 more
europepmc +1 more source
Correction to "CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity". [PDF]
Alzheimers Dementeuropepmc +1 more source
C9orf72 and RAB7L1 regulate vesicle trafficking in amyotrophic lateral sclerosis and frontotemporal dementia [PDF]
Brain, 2017 A non-coding hexanucleotide repeat expansion in intron 1 of the C9orf72 gene is the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia (C9ALS/FTD), however, the precise molecular mechanism by which the C9orf72 hexanucleotide ...
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