Results 151 to 160 of about 202,389 (291)

Nano-modulators with the function of disrupting mitochondrial Ca²⁺ homeostasis and photothermal conversion for synergistic breast cancer therapy. [PDF]

J Nanobiotechnology, 2023
Wang C, Li T, Wang Z, Li Y, Liu Y, Xu M, Zhang Z, Deng Y, Cai L, Zhang C, Li C.   +10 more
europepmc   +1 more source

Dual‐Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti‐Inflammatory and Anti‐Fibrotic Effects

Advanced Science, EarlyView.
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang, Jinwei Li, Shan Hua, Shengming Wu, Chenlong He, Yuan Zhu, Ming Yin, Han Zhou, Huawei Liu, Chika Hasegawa, Jun Lyu, Keyue Xiao, Hua Jiang, Yilong Wang, Yuxin Qian   +14 more
wiley   +1 more source

Perturbation of mitochondrial Ca²⁺ homeostasis activates cross-compartmental proteostatic response in Arabidopsis. [PDF]

Stress Biol
Zhang X, Ma C, Bao X, Zhang S, Zayed O, Zhang Z, Tang K, Xie S, Wang Y, Zhang D, Xu H, Jia H, Wang X, Lei Q, Wang X, Zhang J, Dinesh-Kumar SP, Song CP, Zhu JK, Zhu X.   +19 more
europepmc   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

SERCA2 phosphorylation at serine 663 is a key regulator of Ca²⁺ homeostasis in heart diseases. [PDF]

Nat Commun, 2023
Gonnot F, Boulogne L, Brun C, Dia M, Gouriou Y, Bidaux G, Chouabe C, Crola Da Silva C, Ducreux S, Pillot B, Kaczmarczyk A, Leon C, Chanon S, Perret C, Sciandra F, Dargar T, Gache V, Farhat F, Sebbag L, Bochaton T, Thibault H, Ovize M, Paillard M, Gomez L.   +23 more
europepmc   +1 more source

A Site‐Aware Representation Learning Framework For Unified Molecular Interaction Modeling and Generative Design

Advanced Science, EarlyView.
MolDBG is a site‐aware, sequence‐only framework that unifies drug‐target affinity prediction, binding‐site identification, and affinity‐conditioned molecular generation for structured proteins. Guided by multi‐task binding‐site supervision, it aligns interaction‐critical residues before learning drug‐target representations and simultaneously infers ...
Gang Luo, Qianqian Zhang, Chenhao Wang, Zhiheng Yi, Alex Jinpeng Wang, Jing Tang, Min Li   +6 more
wiley   +1 more source

Next Generation Calcium Nanomaterials: Disrupting Tumor Ca²⁺ Homeostasis for Enhanced Cancer Therapy. [PDF]

Int J Nanomedicine
Gangadhar L, Sana SS, Venkatesan R, Bhandare RR, Kim SC, Yasin HKA.   +5 more
europepmc   +1 more source

Lack of TRPV1 aggravates obesity-associated hypertension through the disturbance of mitochondrial Ca2+ homeostasis in brown adipose tissue. [PDF]

Hypertens Res, 2022
Li L, Ma L, Luo Z, Wei X, Zhao Y, Zhou C, Mou A, Lu Z, You M, He C, Ma H, Zhou Q, Wang L, Cao T, Gu Y, Gao P, Zhu Z.   +16 more
europepmc   +1 more source

Platelet activation and Ca2+ homeostasis.

Blood & Vessel, 1986
NAKASHIMA, Shigeru, NOZAWA, Yoshinori
openaire   +1 more source

OsCPK12‐OsATPD1 Module Regulates Photosynthetic Acclimation to Light Stress in Rice

Advanced Science, EarlyView.
OsCPK12 interacts and phosphorylates OsAtpD1 at Ser8 in its transit peptide. This phosphorylation promote its chloroplast translocation, thereby maintaining ATP synthase activity and proton gradient (ΔpH) homeostasis and regulating photosynthetic acclimation, photoprotection, and repair under light stress.
Beifang Wang, Aaron Chan, Yongyi Fan, Yanwu Wang, Pao Xue, Yingxin Zhang, Xiaodeng Zhan, Weixun Wu, Ping Yu, Daibo Chen, Junlin Fu, Yongbo Hong, Xihong Shen, Lianping Sun, Aike Zhu, Shihua Cheng, Qunen Liu, Liyong Cao   +17 more
wiley   +1 more source