Results 161 to 170 of about 202,389 (291)

The Interplay Between Ca²⁺ Homeostasis, Endoplasmic Reticulum Stress, and the Unfolded Protein Response in Human Diseases. [PDF]

Cells
Ranzato E, Martinotti S.
europepmc   +1 more source

Annexin-A5 is fundamental for VDAC1-dependent mitochondrial Ca2+ homeostasis and determines the susceptibility to apoptosis.

, 2023
Graier W, Oflaz F, Bondarenko A, Trenker M, Waldeck-Weiermair M, Gottschalk B, Bernhart E, Koshenov Z, Radulović S, Rost R, Hirtl M, Pilic J, Leitinger G, Brachvogel B, Summerauer S, Shoshan-Barmatz V, Malli R.   +16 more
europepmc   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

Mesoporous PU/PEDOT:PSS Electrodes Reveal Population‐Level Stochastic Bioelectrical Dynamics in Marine Diatoms

Advanced Science, EarlyView.
Mesoporous mixed ionic‐electronic PU/PEDOT: PSS electrodes enable label‐free detection of stochastic extracellular bioelectrical dynamics in living Phaeodactylum tricornutum. Living diatoms actively modulate interfacial ionic dynamics, establishing stochastic electrochemical noise as a sensitive probe of microbial bioelectrochemical activity and a new ...
David M. S. Silva, Felipe L. Bacellar, Raquel Amaral, Louis‐Josselin Lavier‐Aydat, Luísa Cortes, Kamal Asadi, Leïla Tirichine, Paulo R. F. Rocha   +7 more
wiley   +1 more source

Calcium connections: endoplasmic reticulum Ca²⁺ homeostasis drives spontaneous Ca²⁺ oscillations in guard cells. [PDF]

New Phytol
Pittman JK.
europepmc   +1 more source

A high-salt diet promotes hypertrophic scarring through TRPC3-mediated mitochondrial Ca²⁺ homeostasis dysfunction. [PDF]

Heliyon, 2023
Xia W, Wang Q, Lin S, Wang Y, Zhang J, Wang H, Yang X, Hu Y, Liang H, Lu Y, Zhu Z, Liu D.   +11 more
europepmc   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source

Ca²⁺ homeostasis: a potential target for cancer therapies. [PDF]

Biophys Rep
Su M, Zheng S, Liu H, Tang TS, Hu Y.
europepmc   +1 more source

Role of Microglia and Astrocytes in Alzheimer's Disease: From Neuroinflammation to Ca²⁺ Homeostasis Dysregulation. [PDF]

Cells, 2022
Di Benedetto G, Burgaletto C, Bellanca CM, Munafò A, Bernardini R, Cantarella G.   +5 more
europepmc   +1 more source