Results 31 to 40 of about 305,587 (238)

The cadherin-binding specificities of B-cadherin and LCAM. [PDF]

The Journal of cell biology, 1995
The cadherin family of calcium-dependent cell adhesion molecules plays an important part in the organization of cell adhesion and tissue segregation during development. The expression pattern and the binding specificity of each cadherin are of principal importance for its role in morphogenesis.
Murphy-Erdosh, C, Yoshida, CK, Paradies, N, Reichardt, LF   +3 more
openaire   +5 more sources

Long-term potentiation through calcium-mediated N-Cadherin interaction is tightly controlled by the three-dimensional architecture of the synapse [PDF]

, 2013
Poster presentation: Twenty Second Annual Computational Neuroscience Meeting: CNS*2013. Paris, France. 13-18 July 2013. The synaptic cleft is an extracellular domain that is capable of relaying a presynaptically received electrical signal by diffusive ...
Bunse, Stefanie, Grein, Stephan, Queisser, Sean Gillian, Schuman, Erich   +3 more
core   +1 more source

Design of a Photoswitchable Cadherin [PDF]

Journal of the American Chemical Society, 2013
There is a growing interest in engineering proteins whose function can be controlled with the spatial and temporal precision of light. Here, we present a novel example of a functional light-triggered switch in the Ca-dependent cell-cell adhesion protein E-cadherin, created using a mechanism-based design strategy. We report an 18-fold change in apparent
Kortemme, Tanja, Ritterson, RS, Kuchenbecker, KM, Michalik, M   +3 more
openaire   +5 more sources

A role for the cleaved cytoplasmic domain of E-cadherin in the nucleus [PDF]

, 2008
Cell-cell contacts play a vital role in intracellular signaling, although the molecular mechanisms of these signaling pathways are not fully understood. E-cadherin, an important mediator of cell-cell adhesions, has been shown to be cleaved by γ-secretase.
Ariga, H, Daniel, J, Ferber, EC, Fujita, Y, Kajita, M, Niessen, C, Tobiansky, L, Wadlow, A   +7 more
core   +2 more sources

Differential Displacement of Classical Cadherins by VE-Cadherin [PDF]

Cell Communication & Adhesion, 2002
VE-cadherin is an endothelial cell-specific, type II classical cadherin that plays an important role in permeability, vasculogenesis, and vascular remodeling. Endothelial cells express equal levels of VE- and N-cadherin; VE-cadherin is present injunctions while N-cadherin is diffusely expressed over the surface of the cell.
Keith R. Johnson, Margaret J. Wheelock, Meena Jaggi   +2 more
openaire   +3 more sources

Breaking the VE-cadherin bonds [PDF]

, 2008
Exchanges between the blood compartment and the surrounding tissues require a tight regulation by the endothelial barrier. Recent reports inferred that VE-cadherin, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the ...
Alexander, Allport, Antonetti, Bibert, Birukova, Carmeliet, Crosby, Dejana, Dewi, Eliceiri, Esser, Essler, Farmer, Fukuhara, Fukuhara, Gamble, Garcia, Gavard, Gavard, Gavard, Gavard, Goeckeler, Gory, Jho, Jones, Julie Gavard, Kobielak, Kowalczyk, Leckband, Mammoto, Matter, Moy, Murakami, Navaratna, Nitta, Orlova, Orr, Paik, Paul, Potter, Saharinen, Scheppke, Singh, Stockton, Taddei, Thurston, Wallez, Weis, Weis, Xiao, Yagi   +50 more
core   +4 more sources

Structural determinants of adhesion by Protocadherin-19 and implications for its role in epilepsy

eLife, 2016
Non-clustered δ-protocadherins are homophilic cell adhesion molecules essential for the development of the vertebrate nervous system, as several are closely linked to neurodevelopmental disorders. Mutations in protocadherin-19 (PCDH19) result in a female-
Sharon R Cooper, James D Jontes, Marcos Sotomayor   +2 more
doaj   +1 more source

Clinical significance of epithelial-to-mesenchymal transition in laryngeal carcinoma: Its role in the different subsites [PDF]

, 2017
Background: During epithelial-to-mesenchymal transition, cancer cells lose adhesion capacity gaining migratory properties. The role of the process on prognosis has been evaluated in 50 cases of laryngeal carcinoma.
Carletti, R, Chiappetta, C, Cortesi, E, Di Gioia, C., Mezi, S, Nardini, A, Orsi, E, Piesco, G   +7 more
core   +1 more source

The cadherin superfamily [PDF]

WormBook, 2005
The cadherins are a major class of membrane proteins with prominent roles in cell adhesion, and the regulation of tissue organisation and morphogenesis. The C. elegans genome encodes 13 cadherins, including representatives of the major cadherin sub-types that are conserved between insects and vertebrates: the so-called classic, Fat-like, Flamingo and ...
openaire   +3 more sources

Autoregulation of E-cadherin expression by cadherin–cadherin interactions [PDF]

The Journal of Cell Biology, 2003
Transcriptional repression of E-cadherin, characteristic of epithelial to mesenchymal transition, is often found also during tumor cell invasion. At metastases, migratory fibroblasts sometimes revert to an epithelial phenotype, by a process involving regulation of the E-cadherin–β-catenin complex. We investigated the molecular basis of this regulation,
Conacci-Sorrell, Maralice, Simcha, Inbal, Ben-Yedidia, Tamar, Blechman, Janna, Savagner, Pierre, Ben-Ze'Ev, Avri   +5 more
openaire   +4 more sources