Results 31 to 40 of about 383,770 (381)

The Cadherin Protein Is Not Involved in Susceptibility to Bacillus thuringiensis Cry1Ab or Cry1Fa Toxins in Spodoptera frugiperda

Toxins, 2020
It is well known that insect larval midgut cadherin protein serves as a receptor of Bacillus thuringiensis (Bt) crystal Cry1Ac or Cry1Ab toxins, since structural mutations and downregulation of cad gene expression are linked with resistance to Cry1Ac ...
Jianfeng Zhang, Minghui Jin, Yanchao Yang, Leilei Liu, Yongbo Yang, Isabel Gómez, Alejandra Bravo, Mario Soberón, Yutao Xiao, Kaiyu Liu   +9 more
doaj   +1 more source

A role for the cleaved cytoplasmic domain of E-cadherin in the nucleus [PDF]

, 2008
Cell-cell contacts play a vital role in intracellular signaling, although the molecular mechanisms of these signaling pathways are not fully understood. E-cadherin, an important mediator of cell-cell adhesions, has been shown to be cleaved by γ-secretase.
Ariga, H, Daniel, J, Ferber, EC, Fujita, Y, Kajita, M, Niessen, C, Tobiansky, L, Wadlow, A   +7 more
core   +2 more sources

The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges

Cells, 2019
Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis where the EMT program enhances metastasis, chemoresistance and tumor stemness.
C. Loh, J. Chai, T. F. Tang, W. Wong, G. Sethi, M. Shanmugam, P. Chong, C. Looi   +7 more
semanticscholar   +1 more source

E-cadherin is required for metastasis in multiple models of breast cancer

Nature, 2019
Metastasis is the major driver of death in patients with cancer. Invasion of surrounding tissues and metastasis have been proposed to initiate following loss of the intercellular adhesion protein, E-cadherin1,2, on the basis of inverse correlations ...
Veena Padmanaban, Ilona Krol, Yasir Suhail, B. Szczerba, N. Aceto, J. Bader, A. Ewald   +6 more
semanticscholar   +1 more source

E-cadherin in Contact Inhibition and Cancer

Oncogene, 2018
E-cadherin is a key component of the adherens junctions that are integral in cell adhesion and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells is important in mediating contact inhibition of proliferation when cells
Alisha M. Mendonsa, T. Na, B. Gumbiner
semanticscholar   +1 more source

The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional Repressors ZEB1 and ZEB2*

Journal of Biological Chemistry, 2008
MicroRNAs are small non-coding RNA molecules that can regulate gene expression by interacting with multiple mRNAs and inducing either translation suppression or degradation of mRNA.
M. Korpal, Esther S. Lee, G. Hu, Yibin Kang   +3 more
semanticscholar   +1 more source

N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer

BMC Cancer, 2018
In many types of solid tumours, the aberrant expression of the cell adhesion molecule N-cadherin is a hallmark of epithelial-to-mesenchymal transition, resulting in the acquisition of an aggressive tumour phenotype.
K. Mrozik, O. Blaschuk, C. Cheong, A. Zannettino, K. Vandyke   +4 more
semanticscholar   +1 more source

Substrate stiffness and VE-cadherin mechano-transduction coordinate to regulate endothelial monolayer integrity. [PDF]

, 2017
The vascular endothelium is subject to diverse mechanical cues that regulate vascular endothelial barrier function. In addition to rigidity sensing through integrin adhesions, mechanical perturbations such as changes in fluid shear stress can also ...
Andresen Eguiluz, Roberto C, Kaylan, Kerim B, Leckband, Deborah E, Underhill, Gregory H   +3 more
core   +1 more source

The Art of Mast Cell Adhesion

Cells, 2020
Cell adhesion is one of the basic phenomena occurring in a living organism, affecting many other processes such as proliferation, differentiation, migration, or cell viability.
Joanna Pastwińska, Paulina Żelechowska, Aurelia Walczak-Drzewiecka, Ewa Brzezińska-Błaszczyk, Jarosław Dastych   +4 more
doaj   +1 more source

Desmoglein-2 as a cancer modulator: friend or foe?

Frontiers in Oncology, 2023
Desmoglein-2 (DSG2) is a calcium-binding single pass transmembrane glycoprotein and a member of the large cadherin family. Until recently, DSG2 was thought to only function as a cell adhesion protein embedded within desmosome junctions designed to enable
Kay K. Myo Min, Charlie B. Ffrench, Barbara J. McClure, Barbara J. McClure, Michael Ortiz, Emma L. Dorward, Michael S. Samuel, Michael S. Samuel, Michael S. Samuel, Lisa M. Ebert, Lisa M. Ebert, Mỹ G. Mahoney, Claudine S. Bonder, Claudine S. Bonder   +13 more
doaj   +1 more source