Influenza NG-34 T cell conserved epitope adjuvanted with CAF01 as a possible influenza vaccine candidate [PDF]
Veterinary Research, 2020 Conserved epitopes are targets commonly researched to be part of universal vaccine candidates against influenza viruses (IV). These conserved epitopes need to be cross-protecting against distinct IV subtypes and to have a strong immunogenic potential ...
Marta Sisteré-Oró +5 more
doaj +12 more sources
A CAF01-adjuvanted whole asexual blood-stage liposomal malaria vaccine induces a CD4+ T-cell-dependent strain-transcending protective immunity in rodent models [PDF]
mBio, 2023 Malaria is a leading cause of illness and death in children under 5 years of age in Sub-Saharan Africa. Currently, there is no highly efficacious malaria vaccine capable of inducing long-lasting immunity.
Winter A. Okoth +11 more
doaj +5 more sources
Intrapulmonary (i.pulmon.) Pull Immunization With the Tuberculosis Subunit Vaccine Candidate H56/CAF01 After Intramuscular (i.m.) Priming Elicits a Distinct Innate Myeloid Response and Activation of Antigen-Presenting Cells Than i.m. or i.pulmon. Prime Immunization Alone [PDF]
Frontiers in Immunology, 2020 Understanding the in vivo fate of vaccine antigens and adjuvants and their safety is crucial for the rational design of mucosal subunit vaccines. Prime and pull vaccination using the T helper 17-inducing adjuvant CAF01 administered parenterally and ...
Aneesh Thakur +6 more
doaj +8 more sources
C-type lectin receptor agonists elicit functional IL21-expressing Tfh cells and induce primary B cell responses in neonates [PDF]
Frontiers in Immunology, 2023 IntroductionC-type lectin receptor (CLR) agonists emerged as superior inducers of primary B cell responses in early life compared with Toll-like receptor (TLR) agonists, while both types of adjuvants are potent in adults.MethodsHere, we explored the ...
Maria Vono +15 more
doaj +2 more sources
Heterologous prime-boost immunization combining parenteral and mucosal routes with different adjuvants mounts long-lived CD4+ T cell responses in lungs [PDF]
Frontiers in ImmunologyIntroductionAirway mucosa represents the main entry point for several human pathogens, and as such vaccines against respiratory diseases should ideally elicit protective immune responses in the airways.
Ranmali Kavishna +9 more
doaj +2 more sources
Injection Vaccines Formulated with Nucleotide, Liposomal or Mineral Oil Adjuvants Induce Distinct Differences in Immunogenicity in Rainbow Trout [PDF]
Vaccines, 2020 Protection facilitated by the widespread use of mineral oil adjuvanted injection vaccines in salmonid fish comes with adverse effects of varying severity. In this study, we characterized the immunological profiles of two alternative vaccine formulations,
Kasper Rømer Villumsen +4 more
doaj +4 more sources
Mincle-dependent Th17 adjuvanticity requires TNFR1 signaling in myeloid cells [PDF]
Frontiers in ImmunologySuccessful induction of protective T cells by recombinant protein vaccines requires adjuvants. The liposomal adjuvant system CAF01 induces robust Th17 responses in mice.
Robert Blamberg +9 more
doaj +2 more sources
Dose-sparing effects of novel adjuvants and aluminum hydroxide on two different vaccines in a neonatal mouse model [PDF]
Frontiers in ImmunologyChildhood vaccination provides protection against infectious diseases, but multiple vaccinations are required to achieve this. In situations like influenza epidemics or COVID-19 pandemic, vaccine demands may exceed production capacity, highlighting the ...
Jenny Lorena Molina Estupiñan +14 more
doaj +2 more sources
Intramuscular priming and intranasal boosting induce strong genital immunity through secretory IgA in minipigs infected with Chlamydia trachomatis [PDF]
Frontiers in Immunology, 2015 International efforts in developing a vaccine against Chlamydia trachomatis have highlighted the need for novel immunization strategies for the induction of genital immunity. In this study, we evaluated an intramuscular prime/intranasal boost vaccination
Emma eLorenzen +10 more
doaj +4 more sources
Mitochondrial transfer from cancer-associated fibroblasts increases migration in aggressive breast cancer. [PDF]
J Cell Sci, 2023 Cancer-associated fibroblasts (CAFs) have distinct roles within the tumor microenvironment, which can impact the mode and efficacy of tumor cell migration.
Goliwas KF +8 more
europepmc +3 more sources