Results 21 to 30 of about 1,197 (161)

Toxin expression during Staphylococcus aureus infection imprints host immunity to inhibit vaccine efficacy [PDF]

npj Vaccines, 2023
Staphylococcus aureus infections are a major public health issue, and a vaccine is urgently needed. Despite a considerable promise in preclinical models, all vaccines tested thus far have failed to protect humans against S. aureus. Unlike laboratory mice,
Omid Teymournejad, Zhaotao Li, Pavani Beesetty, Ching Yang, Christopher P. Montgomery   +4 more
doaj   +2 more sources

Tailoring Tfh profiles enhances antibody persistence to a clade C HIV-1 vaccine in rhesus macaques [PDF]

eLife
CD4 T follicular helper cells (Tfh) are essential for establishing serological memory and have distinct helper attributes that impact both the quantity and quality of the antibody response.
Anil Verma, Chase E Hawes, Sonny R Elizaldi, Justin C Smith, Dhivyaa Rajasundaram, Gabriel Kristian Pedersen, Xiaoying Shen, LaTonya D Williams, Georgia D Tomaras, Pamela A Kozlowski, Rama R Amara, Smita S Iyer   +11 more
doaj   +2 more sources

Dual-Isotope SPECT/CT Imaging of the Tuberculosis Subunit Vaccine H56/CAF01: Induction of Strong Systemic and Mucosal IgA and T-Cell Responses in Mice Upon Subcutaneous Prime and Intrapulmonary Boost Immunization [PDF]

Frontiers in Immunology, 2018
Pulmonary tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb), remains a global pandemic, despite the widespread use of the parenteral live attenuated Bacillus Calmette–Guérin (BCG) vaccine during the past decades.
Aneesh Thakur, Cristina Rodríguez-Rodríguez, Cristina Rodríguez-Rodríguez, Katayoun Saatchi, Fabrice Rose, Tullio Esposito, Zeynab Nosrati, Peter Andersen, Dennis Christensen, Urs O. Häfeli, Camilla Foged   +10 more
doaj   +5 more sources

Protection against experimental cryptococcosis elicited by Cationic Adjuvant Formulation 01-adjuvanted subunit vaccines. [PDF]

PLoS Pathogens
The fungal infection, cryptococcosis, is responsible for >100,000 deaths annually. No licensed vaccines are available. We explored the efficacy and immune responses of subunit cryptococcal vaccines adjuvanted with Cationic Adjuvant Formulation 01 (CAF01).
Ruiying Wang, Lorena V N Oliveira, Maureen M Hester, Diana Carlson, Dennis Christensen, Charles A Specht, Stuart M Levitz   +6 more
doaj   +2 more sources

Lipid conjugation of TLR7 agonist Resiquimod ensures co-delivery with the liposomal Cationic Adjuvant Formulation 01 (CAF01) but does not enhance immunopotentiation compared to non-conjugated Resiquimod+CAF01 [PDF]

Journal of Controlled Release, 2018
Pattern recognition receptors, including the Toll-like receptors (TLRs), are important in the induction and activation of two critical arms of the host defence to pathogens and microorganisms; the rapid innate immune response (as characterised by the ...
Christensen, Dennis, Lattmann, Eric, Pedersen, Gabriel, Perrie, Yvonne, Roces, Carla B., Wilkinson, Alexander   +5 more
core   +5 more sources

Characterization of the antigen-specific CD4+ T cell response induced by prime-boost strategies with CAF01 and CpG adjuvants administered by the intranasal and subcutaneous routes [PDF]

Frontiers in Immunology, 2015
The design of heterologous prime-boost vaccine combinations that optimally shape the immune response is of critical importance for the development of next generation vaccines.
Annalisa eCiabattini, Gennaro eProta, Dennis eChristensen, Peter eAndersen, Gianni ePozzi, Donata eMedaglini   +5 more
doaj   +5 more sources

Syringe free vaccination with CAF01 Adjuvated Ag85B-ESAT-6 in Bioneedles provides strong and prolonged protection against tuberculosis.

PLoS ONE, 2010
Bioneedles are small hollow sugar based needles administered with a simple compressed air device. In the present study we investigate how incorporation of a subunit vaccine based on TB vaccine hybrid Ag85B-ESAT-6 adjuvated with CAF01 into Bioneedles ...
Dennis Christensen, Thomas Lindenstrøm, Gijsbert van de Wijdeven, Peter Andersen, Else Marie Agger   +4 more
doaj   +3 more sources

Next-generation Candida albicans vaccine VXV-01 containing recombinant Als3p and Hyr1p antigens for invasive Candida infections [PDF]

Scientific Reports
Candida species, including Candida albicans and Candida auris, represent a growing public health concern due to their increasing prevalence and resistance to antifungal agents. C.
Shakti Singh, Eman G. Youssef, Ashley Barbarino, Haley Hautau, Sunna Nabeela, Teclegiorgis Gebremariam, Sondus Alkhazraji, Gary Ostroff, Dennis Christensen, Terrence Cochrane, Ashraf S. Ibrahim   +10 more
doaj   +2 more sources

Alternatives to mineral oil adjuvants in vaccines against Aeromonas salmonicida subsp. salmonicida in rainbow trout offer reductions in adverse effects [PDF]

Scientific Reports, 2017
In an effort to reduce the frequency and severity of adverse reactions seen from the use of mineral oil adjuvants in salmonid fish, the effects of two alternative adjuvants were assessed, focusing on the induction of adverse effects as well as protection.
Kasper Rømer Villumsen, Erling Olaf Koppang, Dennis Christensen, Anders Miki Bojesen   +3 more
doaj   +3 more sources

Cross-Protective Potential and Protection-Relevant Immune Mechanisms of Whole Inactivated Influenza Virus Vaccines Are Determined by Adjuvants and Route of Immunization [PDF]

Frontiers in Immunology, 2019
Adjuvanted whole inactivated virus (WIV) influenza vaccines show promise as broadly protective influenza vaccine candidates. Using WIV as basis we assessed the relative efficacy of different adjuvants by carrying out a head-to-head comparison of the ...
Yoshita Bhide, Wei Dong, Inta Gribonika, Daniëlle Voshart, Tjarko Meijerhof, Jacqueline de Vries-Idema, Stephen Norley, Kate Guilfoyle, Sarah Skeldon, Othmar G. Engelhardt, Louis Boon, Dennis Christensen, Nils Lycke, Anke Huckriede   +13 more
doaj   +6 more sources