Genital Infiltrations of CD4+ and CD8+ T Lymphocytes, IgA+ and IgG+ Plasma Cells and Intra-Mucosal Lymphoid Follicles Associate With Protection Against Genital Chlamydiatrachomatis Infection in Minipigs Intramuscularly Immunized With UV-Inactivated Bacteria Adjuvanted With CAF01 [PDF]
Frontiers in Microbiology, 2019 The development of a vaccine against genital chlamydia in women is advancing, and the evaluation of in situ immune responses following vaccination and challenge infections is crucial for development of a safe and protective vaccine.
Karin Erneholm +12 more
doaj +5 more sources
Investigating Prime-Pull Vaccination through a Combination of Parenteral Vaccination and Intranasal Boosting [PDF]
Vaccines, 2019 Formulation of inhalable delivery systems containing tuberculosis (TB) antigens to target the site of infection (lungs) have been considered for the development of subunit vaccines. Inert delivery systems such as poly (lactic-co-glycolic acid) (PLGA) are
Carla B. Roces +4 more
doaj +3 more sources
Liposomal delivery system/adjuvant for tuberculosis vaccine. [PDF]
Immun Inflamm Dis, 2023 The delivery system and safety regulator are common characteristics of effective adjuvants in tuberculosis (TB) vaccines and the clinical trial stage. Based on our findings, the liposomal system is a superb adjuvant for vaccinations against TB, other intracellular infections, and malignancies.
Moradi M +9 more
europepmc +2 more sources
Physiologically Based Pharmacokinetic Modeling of Caffeine in Preterm Neonates: Influence of Renal Function and Impairment on Dosing. [PDF]
J Clin PharmacolAbstract Currently, the same weight‐based caffeine citrate dosing regimen is applied to all neonates. However, due to differences in growth trajectories by gestational age (GA) and altered caffeine elimination in neonates with renal injury, optimal dosing regimens may differ. In this study, we refined the existing physiologically based pharmacokinetic (
Thomas N, Harer MW, Lim SY.
europepmc +2 more sources
Bacterial outer membrane vesicles and vaccine applications [PDF]
, 2014 Vaccines based on outer membrane vesicles (OMV) were developed more than 20 years ago against Neisseria meningitidis serogroup B. These nano-sized structures exhibit remarkable potential for immunomodulation of immune responses and delivery of “self ...
Acevedo, Reinaldo +10 more
core +7 more sources
International Journal of Mycobacteriology, 2021 Background: The fusion protein H65, composed of Mycobacterium tuberculosis (TB) ESX-secreted antigens, has improved the bacillus Calmette–Guerin-induced immune protection in a mouse model of bovine TB when formulated in the liposomal adjuvant CAF01.
Elizabeth A García +2 more
doaj +1 more source
International consensus statement on allergy and rhinology: Allergic rhinitis – 2023
International Forum of Allergy &Rhinology, Volume 13, Issue 4, Page 293-859, April 2023., 2023 Abstract Background In the 5 years that have passed since the publication of the 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR‐Allergic Rhinitis 2018), the literature has expanded substantially. The ICAR‐Allergic Rhinitis 2023 update presents 144 individual topics on allergic rhinitis (AR), expanded by over 40
Sarah K. Wise +126 more
wiley +1 more source
Advanced Science, Volume 8, Issue 16, August 18, 2021., 2021 Careful antigen selection is essential for development of an effective and safe SARS‐CoV‐2 vaccine. Considering recent advances, peptide vaccines can be ideal substitutes for protein and RNA/DNA‐based vaccines. Peptide vaccines can avoid immunopathological sequences, focus immune responses on neutralizing B‐cell and on T‐cell epitopes, combine antigens
Ahmed O. Shalash +3 more
wiley +1 more source
Mucosal boosting of H56:CAF01 immunization promotes lung-localized T cells and an accelerated pulmonary response to Mycobacterium tuberculosis infection without enhancing vaccine protection [PDF]
Mucosal Immunology, 2019 T cell-mediated protection against Mycobacterium tuberculosis (Mtb) is dependent upon the ability to localize within the site of pulmonary infection and directly interact with infected cells. In turn, vaccine strategies to improve rapid T cell targeting of Mtb-infected cells after pulmonary exposure are being actively pursued.
Agger, Else Marie +5 more
core +6 more sources
A liposome-based mycobacterial vaccine induces potent adult and neonatal multifunctional T cells through the exquisite targeting of dendritic cells. [PDF]
PLoS ONE, 2009 BACKGROUND: In the search for more potent and safer tuberculosis vaccines, CAF01 was identified as a remarkable formulation. Based on cationic liposomes and including a synthetic mycobacterial glycolipid as TLR-independent immunomodulator, it induces ...
Arun T Kamath +6 more
doaj +1 more source